UMIN-ICDS Clinical Trial
| Unique ID issued by UMIN | UMIN000063341 |
|---|---|
| Receipt number | R000072502 |
| Scientific Title | The Relationship Between the Neurophysiological Characteristics of the Posterior Parietal Cortex and Upper Limb Motor Function |
| Date of disclosure of the study information | 2026/10/19 |
| Last modified on | 2026/10/19 17:22:06 |
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Basic information
Public title
The Relationship Between the Neurophysiological Characteristics of the Posterior Parietal Cortex and Upper Limb Motor Function
Acronym
The Relationship Between the Neurophysiological Characteristics of the Posterior Parietal Cortex and Upper Limb Motor Function
Scientific Title
The Relationship Between the Neurophysiological Characteristics of the Posterior Parietal Cortex and Upper Limb Motor Function
Scientific Title:Acronym
The Relationship Between the Neurophysiological Characteristics of the Posterior Parietal Cortex and Upper Limb Motor Function
Region
| Japan |
Condition
Condition
healthy adults
Classification by specialty
| Not applicable | Adult |
Classification by malignancy
Others
Genomic information
NO
Objectives
Narrative objectives1
To clarify the relationship between the neurophysiological characteristics of the occipito-parietal cortex and upper limb motor function
Basic objectives2
Efficacy
Basic objectives -Others
Trial characteristics_1
Trial characteristics_2
Developmental phase
Assessment
Primary outcomes
The effects of single-pulse transcranial magnetic stimulation (single-pulse TMS) of the posterior parietal cortex (PPC) on muscle activity in the contralateral upper limb during voluntary movement. Changes in muscle activity will be assessed using electromyography.
Key secondary outcomes
1. Neurophysiological interactions between the posterior parietal cortex (PPC) and the primary motor cortex (M1) during rest, as assessed using paired-pulse transcranial magnetic stimulation (TMS).
2. Errors between the target trajectory and the actual finger trajectory in a visual tracking task using the fingers.
Base
Study type
Interventional
Study design
Basic design
Single arm
Randomization
Non-randomized
Randomization unit
Blinding
Open -no one is blinded
Control
Self control
Stratification
Dynamic allocation
Institution consideration
Blocking
Concealment
Intervention
No. of arms
1
Purpose of intervention
Diagnosis
Type of intervention
| Device,equipment |
Interventions/Control_1
During voluntary movement, a single transcranial magnetic stimulation (TMS) pulse is delivered to the posterior parietal cortex (PPC). During stimulation, the subject moves the index finger of the right hand with a constant force, and muscle activity in the right hand is recorded using electromyography (EMG). The effects of PPC stimulation during movement on muscle activity are evaluated based on the resulting changes in muscle activity. At rest, we apply a double-pulse transcranial magnetic stimulation (TMS) to the posterior parietal cortex (PPC) and the primary motor cortex (M1). We record the electromyographic (EMG) responses elicited by stimulation of M1 and evaluate the neurophysiological interaction between the PPC and M1 by comparing the condition in which M1 is stimulated alone with the condition in which M1 is stimulated following PPC stimulation. We will conduct a visual tracking task in which participants move the index finger of their right hand in sync with a target waveform displayed on a monitor. We will calculate the error between the target waveform and the actual finger movement to evaluate finger motor function.
Interventions/Control_2
Interventions/Control_3
Interventions/Control_4
Interventions/Control_5
Interventions/Control_6
Interventions/Control_7
Interventions/Control_8
Interventions/Control_9
Interventions/Control_10
Eligibility
Age-lower limit
| 18 | years-old | <= |
Age-upper limit
| 27 | years-old | >= |
Gender
Male and Female
Key inclusion criteria
We will use the university's internal email system to notify undergraduate and graduate students of the call for research participants. We will accept as research participants only those students who express an interest in this study and have fully understood its content, and who voluntarily agree to participate in the experiment of their own free will. The eligibility criteria require participants to be between 18 and 27 years of age.
Key exclusion criteria
Participants with implanted metal devices (such as pacemakers), those with claustrophobia, and those with a history of seizures will be excluded from the study.
Target sample size
20
Research contact person
Name of lead principal investigator
| 1st name | Shinnosuke |
| Middle name | |
| Last name | Watanabe |
Organization
Niigata University of Health and Welfare Graduate School
Division name
Graduate School of Health and Welfare Sciences, Department of Health Sciences, Division of Physical Therapy
Zip code
9503198
Address
1398 Shimami-cho, Kita Ward, Niigata City, Niigata Prefecture
TEL
0252574455
hpm26005@nuhw.ac.jp
Public contact
Name of contact person
| 1st name | Shinnosuke |
| Middle name | |
| Last name | Watanabe |
Organization
Niigata University of Health and Welfare Graduate School
Division name
Graduate School of Health and Welfare Sciences, Department of Health Sciences, Division of Physical
Zip code
9503198
Address
1398 Shimami-cho, Kita Ward, Niigata City, Niigata Prefecture
TEL
0252574455
Homepage URL
hpm26005@nuhw.ac.jp
Sponsor or person
Institute
Niigata University of Health and Welfare
Institute
Department
Personal name
Funding Source
Organization
Niigata University of Health and Welfare
Organization
Division
Category of Funding Organization
Other
Nationality of Funding Organization
Other related organizations
Co-sponsor
Name of secondary funder(s)
IRB Contact (For public release)
Organization
Ethics Review Committee, Niigata University of Health and Welfare
Address
1398 Shimami-cho, Kita Ward, Niigata City, Niigata Prefecture
Tel
0252574455
rinri@nuhw.ac.jp
Secondary IDs
Secondary IDs
NO
Study ID_1
Org. issuing International ID_1
Study ID_2
Org. issuing International ID_2
IND to MHLW
Institutions
Institutions
Other administrative information
Date of disclosure of the study information
| 2026 | Year | 10 | Month | 19 | Day |
Related information
URL releasing protocol
Publication of results
Unpublished
Result
URL related to results and publications
Number of participants that the trial has enrolled
Results
Results date posted
Results Delayed
Results Delay Reason
Date of the first journal publication of results
Baseline Characteristics
Participant flow
Adverse events
Outcome measures
Plan to share IPD
IPD sharing Plan description
Progress
Recruitment status
Preinitiation
Date of protocol fixation
| 2026 | Year | 10 | Month | 19 | Day |
Date of IRB
Anticipated trial start date
| 2026 | Year | 10 | Month | 26 | Day |
Last follow-up date
| 2028 | Year | 03 | Month | 31 | Day |
Date of closure to data entry
Date trial data considered complete
Date analysis concluded
Other
Other related information
Management information
Registered date
| 2026 | Year | 10 | Month | 19 | Day |
Last modified on
| 2026 | Year | 10 | Month | 19 | Day |
Link to view the page
Value
https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000072502
