UMIN-ICDS Clinical Trial
| Unique ID issued by UMIN | UMIN000063287 |
|---|---|
| Receipt number | R000072415 |
| Scientific Title | Effects of cathodal high-definition transcranial direct current stimulation over the posterior parietal cortex on updating of gait motor imagery in healthy young adults |
| Date of disclosure of the study information | 2026/10/15 |
| Last modified on | 2026/10/15 02:54:13 |
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Basic information
Public title
Effects of transcranial direct current stimulation over the posterior parietal cortex on gait motor imagery
Acronym
PPC-MI-tDCS Study
Scientific Title
Effects of cathodal high-definition transcranial direct current stimulation over the posterior parietal cortex on updating of gait motor imagery in healthy young adults
Scientific Title:Acronym
PPC-MI-tDCS Study
Region
| Japan |
Condition
Condition
Healthy adults
Classification by specialty
| Rehabilitation medicine | Adult |
Classification by malignancy
Others
Genomic information
NO
Objectives
Narrative objectives1
The aim of this study is to investigate the effect of cathodal high-definition transcranial direct current stimulation over the posterior parietal cortex on the updating of gait motor imagery following actual walking experience in healthy young adults.
Basic objectives2
Others
Basic objectives -Others
Investigation of the functional involvement of the posterior parietal cortex in motor imagery updating
Trial characteristics_1
Confirmatory
Trial characteristics_2
Explanatory
Developmental phase
Not applicable
Assessment
Primary outcomes
Temporal error between imagined and actual walking duration (absolute error [AE] and constant error [CE]), assessed at Pre, immediately after treadmill walking (Mid), and after the rest period (Post).
Key secondary outcomes
Imagined walking duration, actual walking duration, and gait parameters during treadmill walking, including cadence and stride length. Imagined and actual walking durations are assessed at Pre, Mid, and Post, and gait parameters are assessed during treadmill walking.
Base
Study type
Interventional
Study design
Basic design
Parallel
Randomization
Randomized
Randomization unit
Individual
Blinding
Single blind -participants are blinded
Control
Placebo
Stratification
YES
Dynamic allocation
NO
Institution consideration
Institution is not considered as adjustment factor.
Blocking
NO
Concealment
No need to know
Intervention
No. of arms
3
Purpose of intervention
Educational,Counseling,Training
Type of intervention
| Device,equipment |
Interventions/Control_1
High-definition transcranial direct current stimulation (HD-tDCS) is applied over the posterior parietal cortex, with the cathode at P3 and the anodes at CP1, CP5, PO3, and PO7. Active stimulation is delivered at 2 mA for 15 min during treadmill walking, followed by sham stimulation during the subsequent rest period.
Interventions/Control_2
High-definition transcranial direct current stimulation (HD-tDCS) is applied over the posterior parietal cortex, with the cathode at P3 and the anodes at CP1, CP5, PO3, and PO7. Sham stimulation is delivered during treadmill walking, followed by active stimulation at 2 mA for 15 min during the subsequent rest period.
Interventions/Control_3
Sham HD-tDCS is applied over the posterior parietal cortex using the same electrode montage as the active stimulation, with the cathode at P3 and the anodes at CP1, CP5, PO3, and PO7. Sham stimulation is delivered during both treadmill walking and the subsequent rest period.
Interventions/Control_4
Interventions/Control_5
Interventions/Control_6
Interventions/Control_7
Interventions/Control_8
Interventions/Control_9
Interventions/Control_10
Eligibility
Age-lower limit
| 18 | years-old | <= |
Age-upper limit
| 25 | years-old | >= |
Gender
Male and Female
Key inclusion criteria
Healthy young adults
Right-handed individuals
Individuals classified as right-footed based on the Japanese version of the Waterloo Footedness Questionnaire-Revised (total score of +7 or higher)
Individuals who provided informed consent after receiving an explanation of the study procedures
Key exclusion criteria
Individuals with orthopedic, neurological, or psychiatric disorders, including hypomanic or manic states, that may affect the study outcomes
Individuals who meet any exclusion criterion on the safety screening for transcranial electrical stimulation
Individuals considered unsuitable for participation by the investigators
Target sample size
60
Research contact person
Name of lead principal investigator
| 1st name | Kento |
| Middle name | |
| Last name | Sone |
Organization
Kawasaki University of Medical Welfare
Division name
Masters Program in Rehabilitation Graduate School of Health Science and Technology
Zip code
701-0193
Address
288 Matsushima, Kurashiki, Okayama, Japan
TEL
086-462-1111
kento.sone1006@gmail.com
Public contact
Name of contact person
| 1st name | Daisuke |
| Middle name | |
| Last name | Kimura |
Organization
Kawasaki University of Medical Welfare
Division name
Department of Physical Therapy
Zip code
701-0193
Address
288 Matsushima, Kurashiki, Okayama, Japan
TEL
086-462-1111
Homepage URL
kimura.d@mw.kawasaki-m.ac.jp
Sponsor or person
Institute
Kawasaki University of Medical Welfare
Institute
Department
Personal name
Kimura Daisuke
Funding Source
Organization
Kawasaki University of Medical Welfare
Organization
Division
Category of Funding Organization
Other
Nationality of Funding Organization
Japan
Other related organizations
Co-sponsor
Name of secondary funder(s)
IRB Contact (For public release)
Organization
Ethics Committee, Kawasaki University of Medical Welfare
Address
288 Matsushima, Kurashiki, Okayama 701-0193, Japan
Tel
086-464-1010
kenkyu@mw.kawasaki.ne.jp
Secondary IDs
Secondary IDs
NO
Study ID_1
Org. issuing International ID_1
Study ID_2
Org. issuing International ID_2
IND to MHLW
Institutions
Institutions
川崎医療福祉大学（岡山県）
Other administrative information
Date of disclosure of the study information
| 2026 | Year | 10 | Month | 15 | Day |
Related information
URL releasing protocol
Protocol is not publicly available.
Publication of results
Unpublished
Result
URL related to results and publications
Results have not yet been published online.
Number of participants that the trial has enrolled
60
Results
A group-by-time interaction was observed for the absolute error (AE) between imagined and actual walking duration. AE decreased after treadmill walking in the Sham and tDCS-Rest groups, whereas no clear reduction was observed in the tDCS-Gait group. Imagined and actual walking durations decreased in all groups. Improvement in temporal correspondence between imagined and actual walking was attenuated in the tDCS-Gait group compared with the Sham and tDCS-Rest groups.
Results date posted
| 2026 | Year | 10 | Month | 15 | Day |
Results Delayed
Results Delay Reason
Date of the first journal publication of results
Baseline Characteristics
Sixty healthy young adults (31 males and 29 females) participated in the study. Mean age was 20.0 plus or minus 0.9 years and mean height was 163.6 plus or minus 7.9 cm.
Participant flow
Sixty participants were randomly allocated to three groups: Sham (n = 20), tDCS-Gait (n = 20), and tDCS-Rest (n = 20). All participants completed the experimental protocol, and all 60 participants were included in the analysis.
Adverse events
No serious adverse events were observed.
Outcome measures
The primary outcome measures were the temporal errors between imagined and actual walking duration, including absolute error (AE) and constant error (CE). Secondary outcome measures included imagined walking duration, actual walking duration, and gait parameters during treadmill walking, including cadence and stride length. Imagined and actual walking were assessed at Pre, Mid, and Post.
Plan to share IPD
Yes, under certain conditions
IPD sharing Plan description
De-identified individual participant data may be shared upon reasonable request, subject to approval by the principal investigator and any necessary ethical procedures.
Progress
Recruitment status
Completed
Date of protocol fixation
| 2024 | Year | 02 | Month | 08 | Day |
Date of IRB
| 2024 | Year | 02 | Month | 09 | Day |
Anticipated trial start date
| 2024 | Year | 04 | Month | 01 | Day |
Last follow-up date
| 2025 | Year | 04 | Month | 01 | Day |
Date of closure to data entry
Date trial data considered complete
Date analysis concluded
Other
Other related information
Management information
Registered date
| 2026 | Year | 10 | Month | 15 | Day |
Last modified on
| 2026 | Year | 10 | Month | 15 | Day |
Link to view the page
Value
https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000072415
