UMIN-ICDS Clinical Trial
| Unique ID issued by UMIN | UMIN000063080 |
|---|---|
| Receipt number | R000072215 |
| Scientific Title | Effects of isometric knee flexion training at different hip flexion angles on hamstring strength and morphology |
| Date of disclosure of the study information | 2026/09/28 |
| Last modified on | 2026/09/28 18:45:31 |
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Basic information
Public title
Effects of knee flexion training at different hip angles on hamstring strength and muscle morphology
Acronym
Hip-angle Hamstring Training Study
Scientific Title
Effects of isometric knee flexion training at different hip flexion angles on hamstring strength and morphology
Scientific Title:Acronym
Hip-angle Hamstring Training Study
Region
| Japan |
Condition
Condition
Healthy male adults
Classification by specialty
| Adult |
Classification by malignancy
Others
Genomic information
NO
Objectives
Narrative objectives1
To compare changes in knee flexion strength and hamstring muscle morphology following 8 weeks of isometric knee flexion training performed at 0 degrees or 90 degrees of hip flexion and to determine the effects of hip flexion angle on long term training adaptations.
Basic objectives2
Efficacy
Basic objectives -Others
Trial characteristics_1
Confirmatory
Trial characteristics_2
Explanatory
Developmental phase
Not applicable
Assessment
Primary outcomes
Change in maximal isometric knee flexion strength from baseline to 8 weeks.Maximal voluntary isometric contraction MVIC will be assessed at 30 degrees of knee flexion and at hip flexion angles of 0 degrees 45 degrees and 90 degrees with the maximum force or torque recorded for each condition.
Key secondary outcomes
1. Changes in hamstring muscle morphology from baseline to 4 and 8 weeks. Biceps femoris long head fascicle length and muscle thickness, and semitendinosus and semimembranosus muscle thickness will be assessed using ultrasonography.
2. Change in maximal isometric knee flexion strength from baseline to 4 weeks.
Base
Study type
Interventional
Study design
Basic design
Parallel
Randomization
Randomized
Randomization unit
Individual
Blinding
Open -no one is blinded
Control
No treatment
Stratification
NO
Dynamic allocation
NO
Institution consideration
Institution is not considered as adjustment factor.
Blocking
NO
Concealment
No need to know
Intervention
No. of arms
3
Purpose of intervention
Educational,Counseling,Training
Type of intervention
| Other |
Interventions/Control_1
Hip flexion 0 degrees group. Isometric knee flexion training is performed with the dominant leg at 0 degrees of hip flexion and 30 degrees of knee flexion. Participants perform 5 sets of 5 maximal voluntary isometric contractions. Each contraction lasts 5 seconds with 10 seconds of rest between contractions and 1 minute of rest between sets. Training is performed twice per week for 8 weeks for a total of 16 sessions with at least 48 hours between sessions.
Interventions/Control_2
Hip flexion 90 degrees group. Isometric knee flexion training is performed with the dominant leg at 90 degrees of hip flexion and 30 degrees of knee flexion. Participants perform 5 sets of 5 maximal voluntary isometric contractions. Each contraction lasts 5 seconds with 10 seconds of rest between contractions and 1 minute of rest between sets. Training is performed twice per week for 8 weeks for a total of 16 sessions with at least 48 hours between sessions.
Interventions/Control_3
Control group. Participants continue their usual daily activities for 8 weeks without performing the training intervention in this study and are instructed not to begin any new lower limb resistance training.
Interventions/Control_4
Interventions/Control_5
Interventions/Control_6
Interventions/Control_7
Interventions/Control_8
Interventions/Control_9
Interventions/Control_10
Eligibility
Age-lower limit
| 18 | years-old | <= |
Age-upper limit
| 30 | years-old | >= |
Gender
Male
Key inclusion criteria
Healthy males aged 18 to 30 years who regularly engage in physical activity at least twice per week.
Key exclusion criteria
Individuals with pain or injury of the trunk or lower limbs at the time of measurement, those with a medical condition that may affect exercise performance, and those with a history of major trauma or surgery involving the trunk or lower limbs.
Target sample size
42
Research contact person
Name of lead principal investigator
| 1st name | Norikazu |
| Middle name | |
| Last name | Hirose |
Organization
Waseda University
Division name
Faculty of Sport Sciences
Zip code
202-0021
Address
3-4-1 Higashifushimi, Nishitokyo, Tokyo, Japan
TEL
042-451-1022
toitsu_hirose@waseda.jp
Public contact
Name of contact person
| 1st name | Tatsuya |
| Middle name | |
| Last name | Moteki |
Organization
Waseda University
Division name
Graduate School of Sport Sciences
Zip code
202-0021
Address
2-7-5 Higashifushimi, Nishitokyo, Tokyo, Japan
TEL
042-461-1322
Homepage URL
tatsuya.moteki@fuji.waseda.jp
Sponsor or person
Institute
Waseda University
Institute
Department
Personal name
Funding Source
Organization
Japan Science and Technology Agency
Organization
Division
Category of Funding Organization
Japanese Governmental office
Nationality of Funding Organization
Japan
Other related organizations
Co-sponsor
Name of secondary funder(s)
IRB Contact (For public release)
Organization
Ethics Review Committee on Research with Human Subjects of Waseda University
Address
1-104 Totsukamachi, Shinjuku-ku, Tokyo 169-8050, Japan
Tel
03-5272-1639
rinri@list.waseda.jp
Secondary IDs
Secondary IDs
NO
Study ID_1
Org. issuing International ID_1
Study ID_2
Org. issuing International ID_2
IND to MHLW
Institutions
Institutions
早稲田大学東伏見キャンパス（東京都）
Other administrative information
Date of disclosure of the study information
| 2026 | Year | 09 | Month | 28 | Day |
Related information
URL releasing protocol
Publication of results
Unpublished
Result
URL related to results and publications
Number of participants that the trial has enrolled
0
Results
Results date posted
Results Delayed
Results Delay Reason
Date of the first journal publication of results
Baseline Characteristics
Participant flow
Adverse events
Outcome measures
Plan to share IPD
IPD sharing Plan description
Progress
Recruitment status
Preinitiation
Date of protocol fixation
| 2026 | Year | 07 | Month | 20 | Day |
Date of IRB
Anticipated trial start date
| 2026 | Year | 11 | Month | 01 | Day |
Last follow-up date
| 2027 | Year | 06 | Month | 30 | Day |
Date of closure to data entry
Date trial data considered complete
Date analysis concluded
Other
Other related information
Management information
Registered date
| 2026 | Year | 09 | Month | 28 | Day |
Last modified on
| 2026 | Year | 09 | Month | 28 | Day |
Link to view the page
Value
https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000072215
