UMIN-ICDS Clinical Trial
| Unique ID issued by UMIN | UMIN000061876 |
|---|---|
| Receipt number | R000070795 |
| Scientific Title | Effect of Visual Information on Salivary Responses to Taste Stimulation |
| Date of disclosure of the study information | 2026/07/01 |
| Last modified on | 2026/06/11 17:21:00 |
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Basic information
Public title
Effect of Visual Information on Salivary Responses to Taste Stimulation
Acronym
VIS-TASTE Study
Scientific Title
Effect of Visual Information on Salivary Responses to Taste Stimulation
Scientific Title:Acronym
VIS-TASTE Study
Region
| Japan |
Condition
Condition
Not applicable; exploratory study in healthy adults
Classification by specialty
| Not applicable |
Classification by malignancy
Others
Genomic information
NO
Objectives
Narrative objectives1
To examine the effects of differences in visual information during taste stimulation on salivary secretion, salivary alpha-amylase activity, and subjective evaluations in healthy adults.
Basic objectives2
Others
Basic objectives -Others
Exploratory evaluation of the effects of visual information on salivary responses during taste stimulation
Trial characteristics_1
Trial characteristics_2
Developmental phase
Assessment
Primary outcomes
Salivary secretion volume
Key secondary outcomes
Salivary alpha-amylase activity, salivary pH, and Visual Analog Scale (VAS) scores
Base
Study type
Interventional
Study design
Basic design
Cross-over
Randomization
Randomized
Randomization unit
Individual
Blinding
Open -no one is blinded
Control
No treatment
Stratification
Dynamic allocation
Institution consideration
Blocking
Concealment
Intervention
No. of arms
2
Purpose of intervention
Prevention
Type of intervention
| Food |
Interventions/Control_1
Umami stimulation group: Participants receive 10 mL of 0.3% monosodium glutamate solution. Transparent and brown-colored conditions are presented in randomized order, and salivary secretion volume, salivary alpha-amylase activity, salivary pH, and subjective evaluations are assessed.
Interventions/Control_2
Sour stimulation group: Participants receive 10 mL of a 0.1% citric acid solution. Transparent and yellow-colored conditions are presented in randomized order. Salivary secretion volume, salivary alpha-amylase activity, salivary pH, and subjective evaluations are assessed.
Interventions/Control_3
Interventions/Control_4
Interventions/Control_5
Interventions/Control_6
Interventions/Control_7
Interventions/Control_8
Interventions/Control_9
Interventions/Control_10
Eligibility
Age-lower limit
| 18 | years-old | <= |
Age-upper limit
| 65 | years-old | >= |
Gender
Male and Female
Key inclusion criteria
1. Individuals aged 18 years or older and younger than 65 years at the time of consent
2. Individuals who understand the study procedures and provide written informed consent
3. Individuals whose physical condition is stable on the day of the study
Key exclusion criteria
1. Individuals with food allergies, including allergies to MSG, citric acid, or food colorants
2. Individuals who are pregnant or breastfeeding
3. Individuals with acute oral conditions, such as severe stomatitis or acute toothache
4. Individuals with self-reported severe oral dryness or severe underlying diseases that may affect salivary secretion
5. Individuals who smoke on the day of the study
6. Individuals with a history of severe discomfort or allergic symptoms caused by taste stimulation, including MSG or citric acid
7. Individuals judged by the principal investigator or study investigators to be unsuitable for participation
Target sample size
90
Research contact person
Name of lead principal investigator
| 1st name | Kohei |
| Middle name | |
| Last name | Yamaguchi |
Organization
Graduate School of Medical and Dental Sciences, Institute of Science Tokyo
Division name
Dysphagia Rehabilitation
Zip code
113-8549
Address
1-5-45 Yushima, Bunkyo-ku Tokyo 113-8510 Japan
TEL
03-5803-4560
yanma627@yahoo.co.jp
Public contact
Name of contact person
| 1st name | Chika |
| Middle name | |
| Last name | Takahashi |
Organization
Graduate School of Medical and Dental Sciences, Institute of Science Tokyo
Division name
Dysphagia Rehabilitation
Zip code
113-8549
Address
1-5-45 Yushima, Bunkyo-ku Tokyo 113-8510 Japan
TEL
03-5803-4560
Homepage URL
takahashi.dysph@gmail.com
Sponsor or person
Institute
Institute of Science Tokyo
Institute
Department
Personal name
Funding Source
Organization
Institute of Science Tokyo
Organization
Division
Category of Funding Organization
Self funding
Nationality of Funding Organization
Other related organizations
Co-sponsor
Name of secondary funder(s)
IRB Contact (For public release)
Organization
Life Science Ethics Group, Research Infrastructure Management Division, Research Promotion Department, Institute of Science Tokyo
Address
Life Science Ethics Group, Research Infrastructure Management Division, Research Promotion Department, Institute of Science Tokyo 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8510, Japan
Tel
03-5803-4547
+81-3-5803-4547
Secondary IDs
Secondary IDs
NO
Study ID_1
Org. issuing International ID_1
Study ID_2
Org. issuing International ID_2
IND to MHLW
Institutions
Institutions
Other administrative information
Date of disclosure of the study information
| 2026 | Year | 07 | Month | 01 | Day |
Related information
URL releasing protocol
Publication of results
Unpublished
Result
URL related to results and publications
Number of participants that the trial has enrolled
Results
Results date posted
Results Delayed
Results Delay Reason
Date of the first journal publication of results
Baseline Characteristics
Participant flow
Adverse events
Outcome measures
Plan to share IPD
IPD sharing Plan description
Progress
Recruitment status
Preinitiation
Date of protocol fixation
| 2026 | Year | 06 | Month | 11 | Day |
Date of IRB
Anticipated trial start date
| 2026 | Year | 07 | Month | 15 | Day |
Last follow-up date
| 2028 | Year | 03 | Month | 31 | Day |
Date of closure to data entry
Date trial data considered complete
Date analysis concluded
Other
Other related information
Management information
Registered date
| 2026 | Year | 06 | Month | 11 | Day |
Last modified on
| 2026 | Year | 06 | Month | 11 | Day |
Link to view the page
Value
https://center6.umin.ac.jp/cgi-open-bin/icdr_e/ctr_view.cgi?recptno=R000070795
