UMIN-ICDS Clinical Trial

Unique ID issued by UMIN UMIN000061509
Receipt number R000070384
Scientific Title Establishment of a Japanese essential oil and yuzu aromatherapy to improve human energy metabolism and sleep quality.
Date of disclosure of the study information 2026/05/10
Last modified on 2026/05/10 16:40:35

* This page includes information on clinical trials registered in UMIN clinical trial registed system.
* We don't aim to advertise certain products or treatments


Basic information

Public title

Establishment of a Japanese essential oil and yuzu aromatherapy to improve human energy metabolism and sleep quality.

Acronym

Establishment of a Japanese essential oil and yuzu aromatherapy to improve human energy metabolism and sleep quality.

Scientific Title

Establishment of a Japanese essential oil and yuzu aromatherapy to improve human energy metabolism and sleep quality.

Scientific Title:Acronym

Establishment of a Japanese essential oil and yuzu aromatherapy to improve human energy metabolism and sleep quality.

Region

Japan


Condition

Condition

Adult

Classification by specialty

Adult

Classification by malignancy

Others

Genomic information

NO


Objectives

Narrative objectives1

This study investigates whether inhaling the aromatic components of yuzu improves energy metabolism and sleep quality.

Basic objectives2

Efficacy

Basic objectives -Others


Trial characteristics_1


Trial characteristics_2


Developmental phase



Assessment

Primary outcomes

Energy metabolism (energy expenditure, respiratory quotient, fat oxidation, carbohydrate oxidation)

Key secondary outcomes

Serum free fatty acids, hormone secretion, serum metabolites, urine metabolites, sleep EEG, body temperature, heart rate, autonomic nervous activity, gene expression in leukocytes and blood glucose


Base

Study type

Interventional


Study design

Basic design

Cross-over

Randomization

Randomized

Randomization unit

Individual

Blinding

Open -no one is blinded

Control

No treatment

Stratification


Dynamic allocation


Institution consideration


Blocking


Concealment



Intervention

No. of arms

2

Purpose of intervention

Treatment

Type of intervention

Food Behavior,custom

Interventions/Control_1

For two weeks, inhale water vapor before going to bed and while sleeping.

Interventions/Control_2

For two weeks, inhale yuzu fragrance components before going to bed and while sleeping.

Interventions/Control_3


Interventions/Control_4


Interventions/Control_5


Interventions/Control_6


Interventions/Control_7


Interventions/Control_8


Interventions/Control_9


Interventions/Control_10



Eligibility

Age-lower limit

20 years-old <=

Age-upper limit

40 years-old >

Gender

Male

Key inclusion criteria

Persons with no health problems
Persons with no sleep problems

Key exclusion criteria

Smoker
Shift worker
Person with a food allergy to yuzu

Target sample size

20


Research contact person

Name of lead principal investigator

1st name Katsuhiko
Middle name
Last name Yajima

Organization

Josai university

Division name

Faculty of Pharmacy

Zip code

340-0295

Address

1-1 Keyakidai, Sakado, Saitama

TEL

049-271-8015

Email

k-yajima@josai.ac.jp


Public contact

Name of contact person

1st name Katsuhiko
Middle name
Last name Yajima

Organization

Josai university

Division name

Faculty of Pharmacy

Zip code

350-0295

Address

1-1 Keyakidai, Sakado, Saitama

TEL

049-271-8015

Homepage URL


Email

k-yajima@josai.ac.jp


Sponsor or person

Institute

Josai university

Institute

Department

Personal name



Funding Source

Organization

Josai university

Organization

Division

Category of Funding Organization

Other

Nationality of Funding Organization



Other related organizations

Co-sponsor


Name of secondary funder(s)



IRB Contact (For public release)

Organization

Josai university

Address

1-1 Keyakidai, Sakado, Saitama

Tel

049-271-8015

Email

k-yajima@josai.ac.jp


Secondary IDs

Secondary IDs

NO

Study ID_1


Org. issuing International ID_1


Study ID_2


Org. issuing International ID_2


IND to MHLW



Institutions

Institutions

城西大学(埼玉県)


Other administrative information

Date of disclosure of the study information

2026 Year 05 Month 10 Day


Related information

URL releasing protocol


Publication of results

Unpublished


Result

URL related to results and publications


Number of participants that the trial has enrolled


Results


Results date posted


Results Delayed


Results Delay Reason


Date of the first journal publication of results


Baseline Characteristics


Participant flow


Adverse events


Outcome measures


Plan to share IPD


IPD sharing Plan description



Progress

Recruitment status

Open public recruiting

Date of protocol fixation

2025 Year 04 Month 01 Day

Date of IRB

2025 Year 07 Month 28 Day

Anticipated trial start date

2025 Year 07 Month 28 Day

Last follow-up date

2029 Year 03 Month 31 Day

Date of closure to data entry


Date trial data considered complete


Date analysis concluded



Other

Other related information



Management information

Registered date

2026 Year 05 Month 10 Day

Last modified on

2026 Year 05 Month 10 Day



Link to view the page

Value
https://center6.umin.ac.jp/cgi-open-bin/icdr_e/ctr_view.cgi?recptno=R000070384