UMIN-ICDS Clinical Trial
| Unique ID issued by UMIN | UMIN000061303 |
|---|---|
| Receipt number | R000070144 |
| Scientific Title | Comparative effects of knee extension training using plate-loaded and weight-stack machines on quadriceps muscle hypertrophy |
| Date of disclosure of the study information | 2026/04/18 |
| Last modified on | 2026/04/18 00:48:25 |
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Basic information
Public title
Effects of knee extension training using a plate-loaded or weight-stack machine on quadriceps muscle hypertrophy
Acronym
Knee Extension Machine Study
Scientific Title
Comparative effects of knee extension training using plate-loaded and weight-stack machines on quadriceps muscle hypertrophy
Scientific Title:Acronym
Knee Extension Machine for Hypertrophy
Region
| Japan |
Condition
Condition
Healthy young individual
Classification by specialty
| Adult |
Classification by malignancy
Others
Genomic information
NO
Objectives
Narrative objectives1
This study aims to compare the effects of knee extension training using plate-loaded and weight-stack machines on quadriceps muscle hypertrophy.
Basic objectives2
Efficacy
Basic objectives -Others
Trial characteristics_1
Trial characteristics_2
Developmental phase
Assessment
Primary outcomes
Muscle volume
Key secondary outcomes
Base
Study type
Interventional
Study design
Basic design
Parallel
Randomization
Randomized
Randomization unit
Individual
Blinding
Open -but assessor(s) are blinded
Control
Active
Stratification
Dynamic allocation
Institution consideration
Blocking
Concealment
Intervention
No. of arms
2
Purpose of intervention
Educational,Counseling,Training
Type of intervention
| Behavior,custom |
Interventions/Control_1
Participants will perform knee extension training twice weekly for 12 weeks. One leg will be trained using a plate-loaded machine, whereas the contralateral leg will be trained using a weight-stack machine. Each training session will be performed with a prescribed number of repetitions and sets for each leg.
Interventions/Control_2
Participants will perform knee extension training twice weekly for 12 weeks. One leg will be trained using a plate-loaded machine, whereas the contralateral leg will be trained using a weight-stack machine. Each training session will be performed with a prescribed number of repetitions and sets for each leg.
Interventions/Control_3
Interventions/Control_4
Interventions/Control_5
Interventions/Control_6
Interventions/Control_7
Interventions/Control_8
Interventions/Control_9
Interventions/Control_10
Eligibility
Age-lower limit
| 18 | years-old | <= |
Age-upper limit
| 39 | years-old | >= |
Gender
Male and Female
Key inclusion criteria
Healthy young adults
Key exclusion criteria
1. Individuals who have performed exercises targeting the quadriceps femoris (e.g., knee extension exercises or squats) at least twice per week for 12 weeks or more within the past year, or who are currently engaged in such training.
2. Individuals with conditions that may interfere with study participation, including hepatic, renal, or cardiovascular diseases; respiratory disorders; endocrine or metabolic disorders; neurological disorders; disturbances of consciousness; vestibular dysfunction; sleep disorders; cardiovascular and circulatory diseases; diabetes mellitus (as defined by the criteria of the Japan Diabetes Society); or other conditions such as peripheral vascular reflex disorders, acute inflammation, skin diseases, or malignant tumors.
3. Individuals who have reported minor injuries within the past 4 weeks or severe musculoskeletal injuries within the past 6 months.
4. Individuals who are unable or unwilling to provide informed consent.
5. Individuals presenting with severe physical or mental conditions at the time of participation.
6. Individuals with a history of claustrophobia or panic disorder.
7. Individuals who are unable to remain at rest.
8. Individuals who are pregnant.
9. Individuals with a history of epileptic seizures.
10. Individuals with implanted medical devices such as cardiac pacemakers, defibrillators, or artificial heart valves.
11. Individuals with metal in their body (e.g., dental orthodontic bridges, crowns depending on material, clips, etc.).
12. Individuals with tattoos (as tattoo ink may react to magnetic fields).
Target sample size
20
Research contact person
Name of lead principal investigator
| 1st name | Tadao |
| Middle name | |
| Last name | Isaka |
Organization
Ritsumeikan University
Division name
Faculty of Sport and Health Science
Zip code
525-8577
Address
1-1-1, Noji-Higashi, Kusatsu, Shiga
TEL
077-561-2791
isaka@se.ritsumei.ac.jp
Public contact
Name of contact person
| 1st name | Sumiaki |
| Middle name | |
| Last name | Maeo |
Organization
Ritsumeikan University
Division name
Faculty of Sport and Health Science
Zip code
525-8577
Address
1-1-1, Noji-Higashi, Kusatsu, Shiga
TEL
077-561-2791
Homepage URL
s-maeo@fc.ritsumei.ac.jp
Sponsor or person
Institute
Ritsumeikan University
Institute
Department
Personal name
Funding Source
Organization
JSPS
Organization
Division
Category of Funding Organization
Japanese Governmental office
Nationality of Funding Organization
Other related organizations
Co-sponsor
Name of secondary funder(s)
IRB Contact (For public release)
Organization
Ethics Review Committee for Medical and Health Research Involving Human Subjects (natural Sciences), Ritsumeikan University
Address
1-1-1, Noji-Higashi, Kusatsu, Shiga
Tel
077-599-4175
b-rinri@st.ritsumei.ac.jp
Secondary IDs
Secondary IDs
NO
Study ID_1
Org. issuing International ID_1
Study ID_2
Org. issuing International ID_2
IND to MHLW
Institutions
Institutions
Other administrative information
Date of disclosure of the study information
| 2026 | Year | 04 | Month | 18 | Day |
Related information
URL releasing protocol
Publication of results
Unpublished
Result
URL related to results and publications
Number of participants that the trial has enrolled
Results
Results date posted
Results Delayed
Results Delay Reason
Date of the first journal publication of results
Baseline Characteristics
Participant flow
Adverse events
Outcome measures
Plan to share IPD
IPD sharing Plan description
Progress
Recruitment status
Open public recruiting
Date of protocol fixation
| 2025 | Year | 11 | Month | 04 | Day |
Date of IRB
| 2026 | Year | 01 | Month | 28 | Day |
Anticipated trial start date
| 2026 | Year | 04 | Month | 01 | Day |
Last follow-up date
| 2028 | Year | 03 | Month | 31 | Day |
Date of closure to data entry
Date trial data considered complete
Date analysis concluded
Other
Other related information
Management information
Registered date
| 2026 | Year | 04 | Month | 18 | Day |
Last modified on
| 2026 | Year | 04 | Month | 18 | Day |
Link to view the page
Value
https://center6.umin.ac.jp/cgi-open-bin/icdr_e/ctr_view.cgi?recptno=R000070144
