Unique ID issued by UMIN | UMIN000054973 |
---|---|
Receipt number | R000062812 |
Scientific Title | Investigate the effects of anesthetics on salivary function |
Date of disclosure of the study information | 2024/07/16 |
Last modified on | 2024/08/26 12:43:06 |
Subjective and objective evaluation of salivary secretion in oral surgery under general anesthesia.
To determine changes in salivary secretion during general anesthesia.
Investigate the effects of anesthetics on salivary function
Relationship between anesthetics and salivary function
Japan |
Patients over 20 years old who will undergo oral surgery under general anesthesia at Kanagawa Dental University Hospital.
Oral surgery | Dental medicine |
Others
NO
Subjective or objective assessment of saliva production to determine how anesthetics affect saliva production
Pharmacokinetics
Subjective evaluation (salivation and discomfort) using Visual analogue scale from oral surgeon during pharyngeal pack insertion
1. amount of saliva aspiration during tracheal intubation
2. subjective evaluation (salivation and stress) by dental anesthesiologist using Visual Analogue Scale during tracheal intubation
Interventional
Parallel
Randomized
Individual
Double blind -all involved are blinded
Active
3
Treatment
Medicine |
Anesthetic agents used in induction and maintenance of anesthesia in general anesthesia = Remimazolam
Anesthetic agents used in induction and maintenance of anesthesia in general anesthesia = Propofol
Anesthetic agents used in induction of general anesthesia = Propofol, and anesthetic agents used in maintenance of general anesthesia = Inhaled anesthetic agents.
20 | years-old | <= |
Not applicable |
Male and Female
Patients over 20 years old who will undergo oral surgery under general anesthesia at Kanagawa Dental University Hospital
1. people with an ASA-PS of 3 or higher
2. patients who are aware of thirst or are taking drugs that cause thirst
3. patients who have the following on blood drawn prior to the preoperative visit
AST (GOT) or ALT (GPT) greater than 100 IU/L
Serum creatinine > 2.0 mg/dL
HbA1c greater than or equal to 7.5
4. taking benzodiazepines for more than 6 months
5. whose EEG and BIS values may not be properly measured (including vascular lesions)
6. who have a cardiac pacemaker or ICD
7. who have expressed (including verbally) their refusal to participate in this study
8. other subjects deemed inappropriate by the principal investigator
30
1st name | Shota |
Middle name | |
Last name | Tsukimoto |
Kanagawa Dental University
Department of Dental Anesthesiology
238-8570
1-23, Ogawa-cho, Yokosuka, Kanagawa
046-822-8810
tsukimoto@kdu.ac.jp
1st name | Shota |
Middle name | |
Last name | Tsukimoto |
Kanagawa dental university
Department of dental anesthesiology
238-8570
1-23, Ogawa-cho, Yokosuka, Kanagawa
046-822-8810
https://www.kdu.ac.jp/hospital/department/dental/anesthesiology/
tsukimoto@kdu.ac.jp
Kanagawa Dental University
Japan Society for the Promotion of Science
Japanese Governmental office
Kanagawad Dental University
82, Inaoka-cho, Yokosuka, Kanagawa, Japan
046-822-8810
kenkyo@kdu.ac.jp
NO
2024 | Year | 07 | Month | 16 | Day |
Unpublished
Enrolling by invitation
2024 | Year | 06 | Month | 14 | Day |
2024 | Year | 06 | Month | 14 | Day |
2024 | Year | 07 | Month | 16 | Day |
2031 | Year | 03 | Month | 31 | Day |
2024 | Year | 07 | Month | 16 | Day |
2024 | Year | 08 | Month | 26 | Day |
Value
https://center6.umin.ac.jp/cgi-open-bin/icdr_e/ctr_view.cgi?recptno=R000062812
Research Plan | |
---|---|
Registered date | File name |
Research case data specifications | |
---|---|
Registered date | File name |
Research case data | |
---|---|
Registered date | File name |