Unique ID issued by UMIN | UMIN000055054 |
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Receipt number | R000062234 |
Scientific Title | Study on the relationship between clinical course and imaging biomarkers in spinocerebellar degeneration and multiple system atrophy |
Date of disclosure of the study information | 2024/07/24 |
Last modified on | 2024/07/23 06:24:47 |
Study on the relationship between clinical course and image findings in spinocerebellar degeneration and multiple system atrophy
Stydy on the clinical course and image findings in spinocerebellar degeneration and multiple system atrophy
Study on the relationship between clinical course and imaging biomarkers in spinocerebellar degeneration and multiple system atrophy
Study on the clinical course and imaging biomarkers in spinocerebellar degeneration and multiple system atrophy
Japan |
spinocerebellar degeneration and multiple system atrophy
Neurology | Rehabilitation medicine | Adult |
Others
NO
To clarify whether clinical images measured over time are objective indicators of inter-individual variation in clinical severity and intra-individual change over time, and whether they serve as prognostic indicators of clinical symptom progression in patients with spinocerebellar degeneration and multiple system atrophy by retrospective analysis.
Others
Relation between clinical imaging and clinical course
Confirmatory
Pragmatic
Not applicable
Functional Independence Measure(FIM), Scale for the assessment and rating of ataxia (SARA)
International Cooperative Ataxia Rating Scale (ICARS), Unified Multiple System Atrophy Rating Scale (UMSARS), Mini-mental State Examination (MMSE), Frontal Assessment Battery (FAB), 10 Meter Walking Test, Timed UP and Go test, Berg Balance Scale, 9-hole peg test, Box and Block Test, Maximum Phonation test, Goal Attainment Scale (GAS), etc
Observational
Not applicable |
Not applicable |
Male and Female
Patients with spinocerebellar degeneration or multiple system atrophy who were admitted to Morinomiya Hospital from April 2008 to August 2023 and received short-term intensive rehabilitation.
Patients with whom MRI could not be conducted due to claustrophobia, disagreement with the examination, or other reasons.
150
1st name | Ichiro |
Middle name | |
Last name | Miyai |
Morinomiya Hospital
Neurorehabilitation Research Institute
536-0025
2-1-88 Morinomiya, Jyoto-ku, Osaka, Japan.
06-6969-0111
miyai@omichikai.or.jp
1st name | Yuichi |
Middle name | |
Last name | Hiramatsu |
Morinomiya Hospital
Neurorehabilitation Research Institute
536-0025
2-1-88 Morinomiya, Jyoto-ku, Osaka, Japan.
06-6969-0111
hiramatsu@omichikai.or.jp
Omichi-kai Social Medical Corporation
None
Other
Toyama university hospital
IRB
2-1-88 Morinomiya, Joto-ku, Osaka City, Osaka, Japan
06-6969-0111
nrri-jimu@omichikai.or.jp
NO
森之宮病院(大阪府)
2024 | Year | 07 | Month | 24 | Day |
Unpublished
Preinitiation
2024 | Year | 06 | Month | 27 | Day |
2024 | Year | 06 | Month | 27 | Day |
2024 | Year | 07 | Month | 27 | Day |
2028 | Year | 03 | Month | 31 | Day |
Retrospective observational study
Spinocerebellar degeneration and multiple system atrophy patients who were admitted to Morinomiya Hospital between April 2008 and August 2023 and underwent short-term intensive rehabilitation will be included in the study. Cases in which MRI could not be performed due to metal in the body, claustrophobia, or disagreement with the examination will be excluded.
Background information (age, gender, diagnosis, disease duration), clinical evaluation(Functional Independence Measure(FIM),Scale for the assessment and rating of ataxia (SARA), Unified Multiple System Atrophy Rating Scale(UMSARS), International Cooperative Ataxia Rating Scale (ICARS), Mini-mental State Examination (MMSE), Frontal Assessment Battery (FAB),10 Meter Walking Test, Timed UP and Go test, Berg Balance Scale, 9-hole peg test, Box and Block Test, Maximum Phonation test, Goal Attainment Scale (GAS), etc) and MRI imaging (cerebellar hemisphere MR spectroscopy, brain atrophy rated by 3D morphological imaging, fractional anisotropy of the white matter fiber bundles measured by diffusion tensor imaging and functional connectivity measured by resting-state functional MRI) are evaluated.
2024 | Year | 07 | Month | 23 | Day |
2024 | Year | 07 | Month | 23 | Day |
Value
https://center6.umin.ac.jp/cgi-open-bin/icdr_e/ctr_view.cgi?recptno=R000062234
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