UMIN-CTR Clinical Trial
| Unique ID issued by UMIN | UMIN000060649 |
|---|---|
| Receipt number | R000069364 |
| Scientific Title | Comparative Effects of Slow Eccentric and Concentric Training on Knee Osteoarthritis: A Myofascial Chain Perspective |
| Date of disclosure of the study information | 2026/02/11 |
| Last modified on | 2026/02/11 10:57:45 |
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Basic information
Public title
Equivalent Efficacy of Slow Eccentric vs. Concentric Training for Knee Osteoarthritis: A Myofascial Chain Approach in Middle-Aged Women
Acronym
Equivalent Effects of Muscle Actions in KOA Rehabilitation
Scientific Title
Comparative Effects of Slow Eccentric and Concentric Training on Knee Osteoarthritis: A Myofascial Chain Perspective
Scientific Title:Acronym
Eccentric vs. Concentric Training in KOA: A Myofascial Perspective
Region
| Asia(except Japan) |
Condition
Condition
Middle-aged and elderly female patients with moderate to severe knee osteoarthritis symptoms and basic mobility.
Classification by specialty
| Geriatrics | Orthopedics | Rehabilitation medicine |
| Adult |
Classification by malignancy
Others
Genomic information
NO
Objectives
Narrative objectives1
This study aims to examine the comparative efficacy of slow eccentric-only training (SET) and slow concentric-only training (SCT) in improving clinical symptoms in middle-aged and older women with knee osteoarthritis (KOA), grounded in the theoretical framework of myofascial chains.
Basic objectives2
Efficacy
Basic objectives -Others
Trial characteristics_1
Trial characteristics_2
Developmental phase
Assessment
Primary outcomes
Change in WOMAC pain subscale score from baseline to 12 weeks, assessed using the simplified Chinese version of the WOMAC (Western Ontario and McMaster Universities Osteoarthritis Index) scale (version 3.1). Pain is rated on a 5-point Likert scale (0 to 4) across five items, with a total score range of 0 to 20. A reduction in the score indicates improvement.
Key secondary outcomes
Base
Study type
Interventional
Study design
Basic design
Parallel
Randomization
Randomized
Randomization unit
Cluster
Blinding
Open -but assessor(s) are blinded
Control
Active
Stratification
Dynamic allocation
Institution consideration
Blocking
Concealment
Intervention
No. of arms
2
Purpose of intervention
Treatment
Type of intervention
| Maneuver |
Interventions/Control_1
Slow Eccentric Training (SET) Group: Participants will perform resistance training focused on eccentric muscle contractions along the myofascial chains (superficial front, back, and lateral lines). Training will be supervised and conducted three times per week for 12 weeks. Each session includes 6 exercises, targeting key muscle groups involved in knee joint stability (e.g., quadriceps, hamstrings, gluteals, gastrocnemius), performed at 60 to 70% of 1 to RM, with 3 sets of 8 to 10 repetitions per exercise. The eccentric phase of each repetition will be executed at a slow tempo of 8 to 10 seconds, while concentric movement is minimized or assisted. Training intensity is adjusted biweekly based on reassessed 1 to RM. All sessions will be led by certified physical therapists.
Interventions/Control_2
Slow Concentric Training (SCT) Group: Participants will perform resistance training focused on concentric muscle contractions along the myofascial chains (superficial front, back, and lateral lines). Training will be conducted three times per week for 12 weeks under professional supervision. Each session includes 6 exercises targeting major lower limb muscle groups (e.g., quadriceps, hamstrings, gluteals, gastrocnemius), performed at 60 to 70% of 1 to RM, with 3 sets of 8 to 10 repetitions per exercise. The concentric phase of each repetition will be performed at a slow tempo of 8 to 10 seconds, while the eccentric phase is minimized or assisted. Training loads are adjusted biweekly according to reassessed 1 to RM values. All sessions are supervised by certified physical therapists to ensure safety and protocol adherence.
Interventions/Control_3
Interventions/Control_4
Interventions/Control_5
Interventions/Control_6
Interventions/Control_7
Interventions/Control_8
Interventions/Control_9
Interventions/Control_10
Eligibility
Age-lower limit
| 50 | years-old | <= |
Age-upper limit
| 70 | years-old | >= |
Gender
Female
Key inclusion criteria
Female participants aged between 50 and 70 years.
Clinically diagnosed with knee osteoarthritis (KOA) according to the American College of Rheumatology (ACR) criteria.
Radiographic evidence of tibiofemoral osteophytes on X ray imaging.
Experiencing knee joint pain on most days within the past month.
Numeric Rating Scale (NRS) score for knee pain >= 4 in the past week.
Able to understand study instructions and provide written informed consent.
Physically able to participate in supervised resistance training.
Key exclusion criteria
History of knee replacement surgery or scheduled for knee surgery during the study period.
Diagnosed with rheumatoid arthritis, gout, or other forms of inflammatory joint disease.
Severe cardiovascular, respiratory, neurological, or musculoskeletal disorders that may affect exercise tolerance.
Current use of corticosteroid injections or intra-articular hyaluronic acid within the past 3 months.
Body Mass Index (BMI) >= 35
Engaged in structured resistance training in the past 6 months.
Cognitive impairment, mental illness, or inability to follow instructions.
Participation in another clinical trial concurrently.
Target sample size
56
Research contact person
Name of lead principal investigator
| 1st name | Ping |
| Middle name | |
| Last name | Liu |
Organization
Qufu Normal University
Division name
College of Physical Education
Zip code
273165
Address
No. 57, Jingxuan West Road, Qufu City, Shandong Province
TEL
+8613639443653
liu2578794@gmail.com
Public contact
Name of contact person
| 1st name | Ping |
| Middle name | |
| Last name | Liu |
Organization
Qufu Normal University
Division name
College of Physical Education and Sport Science
Zip code
273165
Address
No. 57, Jingxuan West Road, Qufu City, Shandong Province
TEL
13639443653
Homepage URL
liu2578794@gmail.com
Sponsor or person
Institute
Qufu Normal University
Institute
Department
Personal name
Funding Source
Organization
Qufu Normal University
Organization
Division
Category of Funding Organization
Self funding
Nationality of Funding Organization
Other related organizations
Co-sponsor
Name of secondary funder(s)
IRB Contact (For public release)
Organization
Qufu Normal University
Address
No. 57, Jingxuan West Road, Qufu City, Shandong Province
Tel
+8613639443653
liu2578794@gmail.com
Secondary IDs
Secondary IDs
NO
Study ID_1
Org. issuing International ID_1
Study ID_2
Org. issuing International ID_2
IND to MHLW
Institutions
Institutions
Other administrative information
Date of disclosure of the study information
| 2026 | Year | 02 | Month | 11 | Day |
Related information
URL releasing protocol
Not applicable
Publication of results
Unpublished
Result
URL related to results and publications
Not available
Number of participants that the trial has enrolled
56
Results
Primary outcome
Both groups showed significant improvement in pain after 12 weeks based on WOMAC pain scores. No significant difference was observed between the two groups.
Secondary outcomes
Physical function improved in both groups.
Lower limb strength (1RM and knee extension torque) increased after training.
Fat free mass and lower limb muscle mass increased.
Chair stand and step test performance improved.
Hip internal rotation improved, while no major change was seen in knee joint range or endurance.
Results date posted
| 2026 | Year | 02 | Month | 10 | Day |
Results Delayed
Results Delay Reason
Date of the first journal publication of results
Baseline Characteristics
A total of 56 female participants with knee osteoarthritis were enrolled and randomly assigned into two groups with 28 in each group.
The average age of participants in the slow eccentric training group was 62.4 years and in the slow concentric training group was 63.1 years.
The average body mass index was around 24.8 kilograms per square meter in both groups.
There were no significant differences in baseline characteristics between the two groups.
Participant flow
A total of 56 participants were enrolled and randomized equally into two groups with 28 in each group.
All participants completed the intervention and post intervention assessments.
There were no dropouts or exclusions during the study period.
Adverse events
No adverse events were reported in either group during the intervention period. All participants completed the training safely without injury or discomfort.
Outcome measures
The primary outcome was the change in pain level measured by WOMAC pain scale from baseline to 12 weeks.
Secondary outcomes included improvements in physical function muscle strength body composition functional performance and joint range of motion.
All measurements were taken at baseline and after the 12 week intervention.
Plan to share IPD
IPD sharing Plan description
Progress
Recruitment status
No longer recruiting
Date of protocol fixation
| 2024 | Year | 04 | Month | 05 | Day |
Date of IRB
| 2024 | Year | 04 | Month | 05 | Day |
Anticipated trial start date
| 2024 | Year | 04 | Month | 05 | Day |
Last follow-up date
| 2024 | Year | 04 | Month | 05 | Day |
Date of closure to data entry
Date trial data considered complete
Date analysis concluded
Other
Other related information
Management information
Registered date
| 2026 | Year | 02 | Month | 11 | Day |
Last modified on
| 2026 | Year | 02 | Month | 11 | Day |
Link to view the page
Value
https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000069364
