UMIN-CTR Clinical Trial
| Unique ID issued by UMIN | UMIN000060258 |
|---|---|
| Receipt number | R000068928 |
| Scientific Title | Effect of exercise modalities on blood myokine concentrations |
| Date of disclosure of the study information | 2026/01/05 |
| Last modified on | 2026/01/05 15:00:14 |
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Basic information
Public title
Effect of exercise modalities on blood myokine concentrations
Acronym
Effect of exercise modalities on blood myokine concentrations
Scientific Title
Effect of exercise modalities on blood myokine concentrations
Scientific Title:Acronym
Effect of exercise modalities on blood myokine concentrations
Region
| Japan |
Condition
Condition
healthy adults
Classification by specialty
| Adult |
Classification by malignancy
Others
Genomic information
NO
Objectives
Narrative objectives1
Myokines suppress cognitive decline and several types of cancer, but its secretion requires high-intensity exercise that is often unfeasible for frail patients. This study aims to investigate whether low-intensity neuromuscular electrical stimulation (NMES) can increase circulating myokine levels by inducing localized anaerobic metabolic stress, thereby serving as a "metabolic bypass" that avoids excessive systemic cardiovascular strain.
Basic objectives2
Efficacy
Basic objectives -Others
Trial characteristics_1
Trial characteristics_2
Developmental phase
Assessment
Primary outcomes
Serum SPARC concentration (change from pre- to post-intervention)
Key secondary outcomes
Blood lactate concentration, blood glucose concentration, and heart rate
Base
Study type
Interventional
Study design
Basic design
Cross-over
Randomization
Randomized
Randomization unit
Individual
Blinding
Open -no one is blinded
Control
No treatment
Stratification
Dynamic allocation
Institution consideration
Blocking
Concealment
Intervention
No. of arms
2
Purpose of intervention
Treatment
Type of intervention
| Device,equipment |
Interventions/Control_1
NMES group: 30-min of lower-body NMES applied via belt electrodes at a frequency of 4 Hz. Intensity is set to the highest tolerable level, with a heart rate ceiling of 120% of VT1.
Interventions/Control_2
Control group: 30-min of passive rest in the supine position.
Interventions/Control_3
Interventions/Control_4
Interventions/Control_5
Interventions/Control_6
Interventions/Control_7
Interventions/Control_8
Interventions/Control_9
Interventions/Control_10
Eligibility
Age-lower limit
| 20 | years-old | <= |
Age-upper limit
| Not applicable |
Gender
Male
Key inclusion criteria
Healthy adult men aged 20 years or older
Key exclusion criteria
Presence of orthopedic or neuromuscular disorders, or having implanted electronic devices
Target sample size
12
Research contact person
Name of lead principal investigator
| 1st name | Toshiaki |
| Middle name | |
| Last name | Miyamoto |
Organization
Hyogo Medical University
Division name
School of Rehabilitation
Zip code
650-8530
Address
1-3-6 Minatojima, Chuok-ku, Kobe, Hyogo, Japan
TEL
078-304-3000
t-miyamoto@hyo-med.ac.jp
Public contact
Name of contact person
| 1st name | Toshiaki |
| Middle name | |
| Last name | Miyamoto |
Organization
Hyogo Medical University
Division name
School of Rehabilitation
Zip code
650-8530
Address
1-3-6 Minatojima, Chuo-ku, Kobe, Hyogo, Japan
TEL
078-304-3000
Homepage URL
t-miyamoto@hyo-med.ac.jp
Sponsor or person
Institute
Hyogo Medical University
Institute
Department
Personal name
Funding Source
Organization
JSPS
Organization
Division
Category of Funding Organization
Japanese Governmental office
Nationality of Funding Organization
Other related organizations
Co-sponsor
Name of secondary funder(s)
IRB Contact (For public release)
Organization
Ethical Committee of Hyogo Medical University
Address
1-1 Mukogawacho, Nishinomiya, Hyogo, Japan
Tel
0795-45-6164
rss-adm@hyo-med.ac.jp
Secondary IDs
Secondary IDs
NO
Study ID_1
Org. issuing International ID_1
Study ID_2
Org. issuing International ID_2
IND to MHLW
Institutions
Institutions
Other administrative information
Date of disclosure of the study information
| 2026 | Year | 01 | Month | 05 | Day |
Related information
URL releasing protocol
Publication of results
Unpublished
Result
URL related to results and publications
Number of participants that the trial has enrolled
19
Results
Results date posted
Results Delayed
Results Delay Reason
Date of the first journal publication of results
Baseline Characteristics
Participant flow
Adverse events
Outcome measures
Plan to share IPD
IPD sharing Plan description
Progress
Recruitment status
Completed
Date of protocol fixation
| 2018 | Year | 03 | Month | 22 | Day |
Date of IRB
| 2018 | Year | 03 | Month | 22 | Day |
Anticipated trial start date
| 2018 | Year | 03 | Month | 22 | Day |
Last follow-up date
| 2025 | Year | 12 | Month | 31 | Day |
Date of closure to data entry
Date trial data considered complete
Date analysis concluded
Other
Other related information
Management information
Registered date
| 2026 | Year | 01 | Month | 05 | Day |
Last modified on
| 2026 | Year | 01 | Month | 05 | Day |
Link to view the page
Value
https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000068928
