UMIN-CTR Clinical Trial
| Unique ID issued by UMIN | UMIN000060157 |
|---|---|
| Receipt number | R000068804 |
| Scientific Title | Association between Acute Exercise-Induced Brain Region-Specific Endocannabinoid Expression and Anxiety-Like Behavior in Mice |
| Date of disclosure of the study information | 2025/12/22 |
| Last modified on | 2025/12/22 11:27:06 |
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Basic information
Public title
Association between Acute Exercise-Induced Brain Region-Specific Endocannabinoid Expression and Anxiety-Like Behavior in Mice
Acronym
Association between Acute Exercise-Induced Brain Region-Specific Endocannabinoid Expression and Anxiety-Like Behavior in Mice
Scientific Title
Association between Acute Exercise-Induced Brain Region-Specific Endocannabinoid Expression and Anxiety-Like Behavior in Mice
Scientific Title:Acronym
Association between Acute Exercise-Induced Brain Region-Specific Endocannabinoid Expression and Anxiety-Like Behavior in Mice
Region
| Japan |
Condition
Condition
Healthy male mice
Classification by specialty
| Not applicable |
Classification by malignancy
Others
Genomic information
NO
Objectives
Narrative objectives1
We will infer the molecular mechanisms underlying changes in the human brain, which are difficult to observe directly, based on findings from animal models.
Basic objectives2
Efficacy
Basic objectives -Others
Trial characteristics_1
Trial characteristics_2
Developmental phase
Assessment
Primary outcomes
Brain endocannabinoid concentrations (post-intervention)
Key secondary outcomes
Plasma endocannabinoid concentrations (post-intervention)
Anxiety-like behavior (Open Field Test, Elevated Plus Maze; post-intervention)
Base
Study type
Interventional
Study design
Basic design
Parallel
Randomization
Randomized
Randomization unit
Individual
Blinding
Open -no one is blinded
Control
No treatment
Stratification
Dynamic allocation
Institution consideration
Blocking
Concealment
Intervention
No. of arms
4
Purpose of intervention
Prevention
Type of intervention
| Other |
Interventions/Control_1
non-stress+rest, the stress condition consisted of restraint in a 50-mL conical tube for 2 hours, while the exercise condition involved treadmill running at 10 m/min.
Interventions/Control_2
non-stress+exercise, the stress condition consisted of restraint in a 50-mL conical tube for 2 hours, while the exercise condition involved treadmill running at 10 m/min.
Interventions/Control_3
stress+rest, the stress condition consisted of restraint in a 50-mL conical tube for 2 hours, while the exercise condition involved treadmill running at 10 m/min.
Interventions/Control_4
stress+exercise, the stress condition consisted of restraint in a 50-mL conical tube for 2 hours, while the exercise condition involved treadmill running at 10 m/min.
Interventions/Control_5
Interventions/Control_6
Interventions/Control_7
Interventions/Control_8
Interventions/Control_9
Interventions/Control_10
Eligibility
Age-lower limit
| 6 | weeks-old | <= |
Age-upper limit
| 7 | weeks-old | >= |
Gender
Male
Key inclusion criteria
Healthy male C57BL/6J mice, aged 8 weeks, experimentally naive, and acclimatized to laboratory conditions.
Key exclusion criteria
Mice were excluded from the analysis if they showed visible signs of injury or refused to run on the treadmill despite encouragement.
Target sample size
32
Research contact person
Name of lead principal investigator
| 1st name | TETSUYA |
| Middle name | |
| Last name | YABE |
Organization
Yamanashi Gakuin University
Division name
Faculty of Sport Science
Zip code
400-8575
Address
Sakaori2-4-5, Kofu-shi, Yamanashi, Japan
TEL
055-224-1377
yabe.tetsuya@c2c.ac.jp
Public contact
Name of contact person
| 1st name | TETSUYA |
| Middle name | |
| Last name | YABE |
Organization
Yamanashi Gakuin University
Division name
Faculty of Sport Science
Zip code
400-8575
Address
Sakaori2-4-5, Kofu-shi, Yamanashi, Japan
TEL
055-224-1377
Homepage URL
yabe.tetsuya@c2c.ac.jp
Sponsor or person
Institute
Yamanashi Gakuin University
Institute
Department
Personal name
Funding Source
Organization
Ministry of Education, Culture, Sports, Science and Technology
Organization
Division
Category of Funding Organization
Japanese Governmental office
Nationality of Funding Organization
Other related organizations
Co-sponsor
Name of secondary funder(s)
IRB Contact (For public release)
Organization
The Animal Experiment Committee of Yamanashi Gakuin University
Address
Sakaori2-4-5, Kofu-shi, Yamanashi, Japan
Tel
055-224-1234
kakenhi@c2c.ac.jp
Secondary IDs
Secondary IDs
NO
Study ID_1
Org. issuing International ID_1
Study ID_2
Org. issuing International ID_2
IND to MHLW
Institutions
Institutions
Other administrative information
Date of disclosure of the study information
| 2025 | Year | 12 | Month | 22 | Day |
Related information
URL releasing protocol
Publication of results
Unpublished
Result
URL related to results and publications
Number of participants that the trial has enrolled
32
Results
Results date posted
Results Delayed
Results Delay Reason
Date of the first journal publication of results
Baseline Characteristics
Participant flow
Adverse events
Outcome measures
Plan to share IPD
IPD sharing Plan description
Progress
Recruitment status
No longer recruiting
Date of protocol fixation
| 2025 | Year | 06 | Month | 01 | Day |
Date of IRB
| 2025 | Year | 06 | Month | 30 | Day |
Anticipated trial start date
| 2025 | Year | 07 | Month | 15 | Day |
Last follow-up date
| 2026 | Year | 03 | Month | 31 | Day |
Date of closure to data entry
Date trial data considered complete
Date analysis concluded
Other
Other related information
Management information
Registered date
| 2025 | Year | 12 | Month | 22 | Day |
Last modified on
| 2025 | Year | 12 | Month | 22 | Day |
Link to view the page
Value
https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000068804
