UMIN-CTR Clinical Trial

Public title

A Study on the Relationship Between Vertigo/Dizziness and Meteorological Factors

Acronym

V/D & Weather Study

Scientific Title

A Study on the Relationship Between Vertigo/Dizziness and Meteorological Factors

Scientific Title:Acronym

V/D & Weather Study

Region

Japan

Condition

vertigo/dizziness

Classification by specialty

Medicine in general	Neurology	Oto-rhino-laryngology
Emergency medicine

Classification by malignancy

Others

Genomic information

NO

Narrative objectives1

To statistically analyze the association between the daily number of emergency transports for vertigo/dizziness and meteorological factors (temperature, humidity, precipitation, atmospheric pressure, wind speed, and sunshine duration) in order to clarify the impact of weather conditions on the occurrence of vertigo/dizziness.

Basic objectives2

Others

Basic objectives -Others

A retrospective observational study investigating the association between meteorological factors and the number of vertigo/dizziness cases.

Trial characteristics_1

Exploratory

Trial characteristics_2

Explanatory

Developmental phase

Not applicable

Primary outcomes

Association between the daily number of emergency transports for vertigo/dizziness and meteorological factors, including mean temperature, maximum/minimum temperature, diurnal temperature range, mean humidity, precipitation, mean atmospheric pressure, sunshine duration, and wind speed.

Key secondary outcomes

Association of patient characteristics (e.g., age, sex, and triage level) and disease subtypes (e.g., central vs. non-central) with meteorological factors such as temperature, humidity, and atmospheric pressure.

Study type

Observational

Basic design

Randomization

Randomization unit

Blinding

Control

Stratification

Dynamic allocation

Institution consideration

Blocking

Concealment

No. of arms

Purpose of intervention

Type of intervention

Interventions/Control_1

Interventions/Control_2

Interventions/Control_3

Interventions/Control_4

Interventions/Control_5

Interventions/Control_6

Interventions/Control_7

Interventions/Control_8

Interventions/Control_9

Interventions/Control_10

Age-lower limit

15

years-old

<=

Age-upper limit

Not applicable

Gender

Male and Female

Key inclusion criteria

Patients aged 15 years or older who were transported by ambulance to the Emergency and General Medicine Center of Nippon Medical School Hospital with vertigo/dizziness as the chief complaint between April 1, 2012, and March 31, 2020.

Key exclusion criteria

Vertigo/dizziness accompanied by loss of consciousness, weakness, vagal reflexes, or other systemic symptoms that were judged by the attending physician to be unsuitable for inclusion
Cases in which it was not possible to determine whether the patient had vertigo or dizziness
Cases with insufficient medical records

Target sample size

1400

Name of lead principal investigator

1st name	Makoto
Middle name
Last name	Suzaki

Organization

Nippon Medical School Hospital

Division name

Department of ER and General Medicine

Zip code

113-8603

Address

1-1-5 Sendagi, Bunkyo-ku, Tokyo 113-8603, Japan

TEL

03-3822-2131

Email

mstnndr1@nms.ac.jp

Name of contact person

1st name	Makoto
Middle name
Last name	Suzaki

Organization

Nippon Medical School Hospital

Division name

Department of ER and General Medicine

Zip code

113-8603

Address

1-1-5 Sendagi, Bunkyo-ku, Tokyo 113-8603, Japan

TEL

+81-3-3822-2131

Homepage URL

Email

mstnndr1@nms.ac.jp

Institute

Nippon Medical School Hospital

Institute

Department

Personal name

Makoto Suzaki

Organization

Nippon Medical School Hospital

Organization

Division

Category of Funding Organization

Other

Nationality of Funding Organization

Co-sponsor

Name of secondary funder(s)

Organization

Nippon Medical School Hospital, Center for Clinical Research

Address

1-1-5 Sendagi, Bunkyo-ku, Tokyo 113-8603, Japan

Tel

+81-3-3822-2131

Email

nms_fuzokurinri@nms.ac.jp

Secondary IDs

NO

Study ID_1

Org. issuing International ID_1

Study ID_2

Org. issuing International ID_2

IND to MHLW

Institutions

Date of disclosure of the study information

2025

Year

10

Month

13

Day

URL releasing protocol

https://upload.umin.ac.jp/

Publication of results

Unpublished

URL related to results and publications

https://www.nms.ac.jp/

Number of participants that the trial has enrolled

1401

Results

This retrospective study analyzed 1,401 ambulance-transported patients with vertigo/dizziness at Nippon Medical School Hospital from April 2012 to March 2020. Patient data (age, sex, triage level, diagnosis) were obtained from electronic medical records and analyzed with meteorological factors (e.g., temperature, humidity, pressure, precipitation, wind, sunshine) from the Japan Meteorological Agency. Data collection and analysis are completed, and the main results are under preparation for publication.

Results date posted

2025

Year

10

Month

10

Day

Results Delayed

Results Delay Reason

Date of the first journal publication of results

Baseline Characteristics

This study analyzed 1,401 ambulance-transported patients with vertigo/dizziness who were brought to Nippon Medical School Hospital between April 1, 2012, and March 31, 2020. The mean age was 59 years, and 63% were female. Most cases were classified as emergent or urgent according to the triage category.

Participant flow

A total of 1,529 patients transported by ambulance with a chief complaint of vertigo/dizziness between April 1, 2012, and March 31, 2020, were identified. After excluding 128 patients who presented with loss of consciousness, limb weakness, or vagal reflexes, 1,401 patients were included in the final analysis.

Adverse events

As this was a retrospective observational study without any intervention or medication, no adverse events occurred as a result of the study procedures.

Outcome measures

The primary outcome was the association between the daily number of ambulance transports for vertigo/dizziness and meteorological factors, including mean, maximum, and minimum temperature, diurnal temperature variation, humidity, precipitation, atmospheric pressure, sunshine duration, and wind speed. The secondary outcomes included associations between patient characteristics (e.g., age, sex, triage level) and disease subtypes (e.g., central vs. non-central) with meteorological factors.

Plan to share IPD

IPD sharing Plan description

Recruitment status

Preinitiation

Date of protocol fixation

2019

Year

10

Month

18

Day

Date of IRB

2019

Year

11

Month

13

Day

Anticipated trial start date

2019

Year

11

Month

14

Day

Last follow-up date

2020

Year

03

Month

31

Day

Date of closure to data entry

Date trial data considered complete

Date analysis concluded

Other related information

This retrospective observational study was conducted at the Department of ER and General Medicine, Nippon Medical School Hospital. The study analyzed ambulance-transported patients presenting with vertigo/dizziness between April 1, 2012, and March 31, 2020. Patient data, including age, sex, date of visit, triage level, and diagnosis, were extracted from electronic medical records, and meteorological data (temperature, humidity, atmospheric pressure, precipitation, wind speed, and sunshine duration) were obtained from the Japan Meteorological Agency (Tokyo Meteorological Observatory). All data collection and analyses have been completed, and the manuscript is currently under preparation for submission.

Registered date

2025

Year

10

Month

10

Day

Last modified on

2025

Year

10

Month

13

Day

Link to view the page

Value
https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000067857

Single case data URL

Value
https://center6.umin.ac.jp/ice/67857