UMIN-CTR Clinical Trial
| Unique ID issued by UMIN | UMIN000059445 |
|---|---|
| Receipt number | R000067840 |
| Scientific Title | Effects of transcranial alternating current stimulation over the right fronto-parietal network on working memory performance |
| Date of disclosure of the study information | 2025/10/17 |
| Last modified on | 2025/10/17 16:35:28 |
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Basic information
Public title
The effects of transcranial current stimulation over the right fronto and parietal on memory
Acronym
The effects of electrical brain stimulation on memory
Scientific Title
Effects of transcranial alternating current stimulation over the right fronto-parietal network on working memory performance
Scientific Title:Acronym
The Effects of tACS on the Frontoparietal Network on Working Memory
Region
| Japan |
Condition
Condition
Healthy adults
Classification by specialty
| Adult |
Classification by malignancy
Others
Genomic information
NO
Objectives
Narrative objectives1
To evaluate the effects of theta and gamma-frequency transcranial alternating current stimulation (tACS) over the right fronto-parietal network on working memory performance.
Basic objectives2
Efficacy
Basic objectives -Others
Trial characteristics_1
Confirmatory
Trial characteristics_2
Pragmatic
Developmental phase
Not applicable
Assessment
Primary outcomes
Working memory performance will be evaluated before and immediately after theta-, gamma-, and sham-transcranial alternating current stimulation (tACS) over the right fronto-parietal network.
The interval between each experimental condition will be at least five days.
Outcome measures: n-back task performance
1. Reaction time for correct responses
2. Accuracy rate
3. d-prime score
Key secondary outcomes
To evaluate adverse effects or discomfort related to tACS, a questionnaire on side effects will be administered three times: immediately after the start of stimulation, 5 minutes after the start, and immediately after the end of stimulation.
The questionnaire items are based on the "Guidelines for the Safety of Low-Intensity Transcranial Electrical Stimulation (2019 Edition)" (Japanese Society of Clinical Neurophysiology, Subcommittee on Brain Stimulation Methods, 2021).
Base
Study type
Interventional
Study design
Basic design
Cross-over
Randomization
Randomized
Randomization unit
Individual
Blinding
Single blind -participants are blinded
Control
Placebo
Stratification
Dynamic allocation
NO
Institution consideration
Institution is not considered as adjustment factor.
Blocking
Concealment
No need to know
Intervention
No. of arms
3
Purpose of intervention
Treatment
Type of intervention
| Device,equipment |
Interventions/Control_1
Theta-band (5 Hz) transcranial alternating current stimulation (tACS) over the right fronto-parietal network
Interventions/Control_2
Gamma-band (40 Hz) transcranial alternating current stimulation (tACS) over the right fronto-parietal network
Interventions/Control_3
Placebo (sham) stimulation over the right fronto-parietal network
Interventions/Control_4
Interventions/Control_5
Interventions/Control_6
Interventions/Control_7
Interventions/Control_8
Interventions/Control_9
Interventions/Control_10
Eligibility
Age-lower limit
| 19 | years-old | <= |
Age-upper limit
| 25 | years-old | > |
Gender
Male and Female
Key inclusion criteria
1. Native Japanese speaker
2.Non-smokers
3. Right-handed healthy adults
4. Normal or corrected vision
5. No history of neurological trauma or mental disorder
Key exclusion criteria
1. History of previous head injury
2. Metal implants in the head
3. History of epileptic seizures
4. History of psychotropic drug use
5. Depressive tendencies (self-rated depression scale of 45 points or more)
Target sample size
30
Research contact person
Name of lead principal investigator
| 1st name | SHUNXIANG |
| Middle name | |
| Last name | SUN |
Organization
Graduate School of Health and Welfare
Division name
Department of Health and Welfare
Zip code
950-3198
Address
1398 Shimami-cho, Kita-ku, Niigata-shi, Niigata
TEL
0252574554
hwd24021@nuhw.ac.jp
Public contact
Name of contact person
| 1st name | Tomonori |
| Middle name | |
| Last name | Nomura |
Organization
Niigata University of Health and Welfare
Division name
Department of Occupational Therapy
Zip code
950-3198
Address
1398 Shimami-cho, Kita-ku, Niigata-shi, Niigata
TEL
0252574554
Homepage URL
nomura@nuhw.ac.jp
Sponsor or person
Institute
Niigata University of Health and Welfare
Institute
Department
Personal name
SUN SHUNXIANG
Funding Source
Organization
Japan Science and Technology Agency
Organization
Division
Category of Funding Organization
Japanese Governmental office
Nationality of Funding Organization
Other related organizations
Co-sponsor
Name of secondary funder(s)
Niigata University of Health and Welfare
IRB Contact (For public release)
Organization
Ethical review board of Niigata University of Health and Welfare
Address
1398 Shimami-cho, Kita-ku, Niigata-shi, Niigata
Tel
0252574455
rinri@nuhw.ac.jp
Secondary IDs
Secondary IDs
NO
Study ID_1
Org. issuing International ID_1
Study ID_2
Org. issuing International ID_2
IND to MHLW
Institutions
Institutions
新潟医療福祉大学
Other administrative information
Date of disclosure of the study information
| 2025 | Year | 10 | Month | 17 | Day |
Related information
URL releasing protocol
Publication of results
Unpublished
Result
URL related to results and publications
Number of participants that the trial has enrolled
Results
Results date posted
Results Delayed
Results Delay Reason
Date of the first journal publication of results
Baseline Characteristics
Participant flow
Adverse events
Outcome measures
Plan to share IPD
IPD sharing Plan description
Progress
Recruitment status
Preinitiation
Date of protocol fixation
| 2025 | Year | 10 | Month | 09 | Day |
Date of IRB
Anticipated trial start date
| 2025 | Year | 10 | Month | 09 | Day |
Last follow-up date
| 2027 | Year | 03 | Month | 31 | Day |
Date of closure to data entry
Date trial data considered complete
Date analysis concluded
Other
Other related information
Management information
Registered date
| 2025 | Year | 10 | Month | 17 | Day |
Last modified on
| 2025 | Year | 10 | Month | 17 | Day |
Link to view the page
Value
https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000067840
