UMIN-CTR Clinical Trial
| Unique ID issued by UMIN | UMIN000058682 |
|---|---|
| Receipt number | R000067100 |
| Scientific Title | Systematic Review of Treatments and Clinical Outcomes for Persistent Postural-Perceptual Dizziness (PPPD) |
| Date of disclosure of the study information | 2025/08/05 |
| Last modified on | 2025/08/03 14:46:54 |
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Basic information
Public title
Systematic Review of Treatments and Clinical Outcomes for Persistent Postural-Perceptual Dizziness (PPPD)
Acronym
Systematic Review and Meta-analysis of Treatments and Clinical Outcomes for Persistent Postural-Perceptual Dizziness (PPPD)
Scientific Title
Systematic Review of Treatments and Clinical Outcomes for Persistent Postural-Perceptual Dizziness (PPPD)
Scientific Title:Acronym
Systematic Review of Treatments and Clinical Outcomes for Persistent Postural-Perceptual Dizziness (PPPD)
Region
| Japan |
Condition
Condition
Persistent Postural-Perceptual Dizziness (PPPD)
Classification by specialty
| Oto-rhino-laryngology |
Classification by malignancy
Others
Genomic information
NO
Objectives
Narrative objectives1
The aim of this study is to systematically evaluate the effectiveness of various treatments for PPPD, including pharmacotherapy, cognitive behavioral therapy (CBT), and vestibular rehabilitation, with respect to symptom improvement, recurrence rate, and quality of life (QOL) outcomes.
Basic objectives2
Others
Basic objectives -Others
symptom improvement, recurrence rate, and quality of life (QOL) outcomes.
Trial characteristics_1
Trial characteristics_2
Developmental phase
Assessment
Primary outcomes
Change in symptom severity scores related to PPPD (pre- and post-treatment)
The primary outcome will be the effect size of treatment on symptom improvement, measured using validated dizziness-related scales such as the Dizziness Handicap Inventory (DHI), Visual Analog Scale (VAS), or other relevant instruments.
Key secondary outcomes
Base
Study type
Others,meta-analysis etc
Study design
Basic design
Randomization
Randomization unit
Blinding
Control
Stratification
Dynamic allocation
Institution consideration
Blocking
Concealment
Intervention
No. of arms
Purpose of intervention
Type of intervention
Interventions/Control_1
Interventions/Control_2
Interventions/Control_3
Interventions/Control_4
Interventions/Control_5
Interventions/Control_6
Interventions/Control_7
Interventions/Control_8
Interventions/Control_9
Interventions/Control_10
Eligibility
Age-lower limit
| Not applicable |
Age-upper limit
| Not applicable |
Gender
Male and Female
Key inclusion criteria
Studies involving adult patients diagnosed with PPPD
Clinical studies evaluating the efficacy of treatments for PPPD, including pharmacological therapy, cognitive behavioral therapy (CBT), or vestibular rehabilitation
Randomized controlled trials (RCTs), prospective or retrospective cohort studies, or case series
Studies reporting changes in symptom severity scores (e.g., DHI, VAS) as primary outcomes
Peer-reviewed articles published in English since 2000
Key exclusion criteria
Studies focusing on vestibular disorders other than PPPD (e.g., Meniere's disease, BPPV, vestibular neuritis)
Studies with unclear diagnostic criteria or mixed patient populations
Review articles, letters, single case reports (n<5), animal studies, or basic science research
Studies lacking sufficient detail on treatment or outcomes for quantitative data extraction
Duplicate publications or overlapping cohorts
Target sample size
Research contact person
Name of lead principal investigator
| 1st name | Takeshi |
| Middle name | |
| Last name | Takahashi |
Organization
Niigata University Graduate School of Medical and Dental Sciences
Division name
Department of Otolaryngology-Head and Neck Surgery
Zip code
951-8510
Address
757 Asahimachidori 1-chome, Chuo-ku, Niigata 951-8510, Japan
TEL
025-227-2307
tt_niigata@yahoo.co.jp
Public contact
Name of contact person
| 1st name | Takeshi |
| Middle name | |
| Last name | Takahashi |
Organization
Faculty of Medical and Dental Sciences, Niigata University Graduate School of Medical and Dental Sci
Division name
Department of Otolaryngology-Head and Neck Surgery
Zip code
951-8510
Address
757 Asahimachidori 1-chome, Chuo-ku, Niigata 951-8510, Japan
TEL
025-227-2307
Homepage URL
tt_niigata@yahoo.co.jp
Sponsor or person
Institute
Niigata University Graduate School of Medical and Dental Sciences
Institute
Department
Personal name
Funding Source
Organization
NA
Organization
Division
Category of Funding Organization
Self funding
Nationality of Funding Organization
Other related organizations
Co-sponsor
Name of secondary funder(s)
IRB Contact (For public release)
Organization
NA
Address
NA
Tel
NA]
NA
Secondary IDs
Secondary IDs
NO
Study ID_1
Org. issuing International ID_1
Study ID_2
Org. issuing International ID_2
IND to MHLW
Institutions
Institutions
Other administrative information
Date of disclosure of the study information
| 2025 | Year | 08 | Month | 05 | Day |
Related information
URL releasing protocol
Publication of results
Unpublished
Result
URL related to results and publications
Number of participants that the trial has enrolled
Results
Results date posted
Results Delayed
Results Delay Reason
Date of the first journal publication of results
Baseline Characteristics
Participant flow
Adverse events
Outcome measures
Plan to share IPD
IPD sharing Plan description
Progress
Recruitment status
Preinitiation
Date of protocol fixation
| 2025 | Year | 08 | Month | 03 | Day |
Date of IRB
Anticipated trial start date
| 2025 | Year | 08 | Month | 03 | Day |
Last follow-up date
| 2025 | Year | 12 | Month | 31 | Day |
Date of closure to data entry
Date trial data considered complete
Date analysis concluded
Other
Other related information
PPPD is a relatively newly defined chronic functional dizziness disorder, and evidence regarding its treatment remains limited. Although various treatment approaches have been reported, systematic comparisons of their effectiveness are lacking. This study aims to comprehensively review the existing literature and identify the most effective treatment strategies for PPPD.
Management information
Registered date
| 2025 | Year | 08 | Month | 03 | Day |
Last modified on
| 2025 | Year | 08 | Month | 03 | Day |
Link to view the page
Value
https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000067100
