UMIN-CTR Clinical Trial
| Unique ID issued by UMIN | UMIN000058572 |
|---|---|
| Receipt number | R000066974 |
| Scientific Title | Joint research on the relationship between brain microstructure, brain deposits, and brain function using MRI in neurodegenerative diseases and neuropsychiatric disorders |
| Date of disclosure of the study information | 2025/07/23 |
| Last modified on | 2025/07/23 20:34:31 |
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Basic information
Public title
Joint research on the relationship between brain microstructure, brain deposits, and brain function using MRI in neurodegenerative diseases and neuropsychiatric disorders
Acronym
Joint research using MRI in neurodegenerative diseases and neuropsychiatric disorders
Scientific Title
Joint research on the relationship between brain microstructure, brain deposits, and brain function using MRI in neurodegenerative diseases and neuropsychiatric disorders
Scientific Title:Acronym
Joint research using MRI in neurodegenerative diseases and neuropsychiatric disorders
Region
| Japan |
Condition
Condition
Neurodegenerative diseases and neuropsychiatric disorders
Classification by specialty
| Neurology | Psychiatry | Radiology |
| Neurosurgery |
Classification by malignancy
Others
Genomic information
NO
Objectives
Narrative objectives1
The purpose of this study is to identify MRI markers related to brain microstructure, brain deposits, and brain function in neurodegenerative and psychiatric disorders, and to compare them with those of healthy individuals.
Basic objectives2
Others
Basic objectives -Others
By evaluating the relationship between the MRI markers, PET accumulation and other clinical biomarkers, we will identify the lesions associated with each disease and assess whether each MRI marker can be used for disease evaluation.
Trial characteristics_1
Trial characteristics_2
Developmental phase
Assessment
Primary outcomes
Significant differences in MRI markers (quantitative values) related to brain microstructure, brain deposits, and brain function between patients with each disease and healthy controls
Key secondary outcomes
Correlation between each MRI marker and PET accumulation, blood biomarkers, neuropsychological tests, and clinical symptoms
Base
Study type
Observational
Study design
Basic design
Randomization
Randomization unit
Blinding
Control
Stratification
Dynamic allocation
Institution consideration
Blocking
Concealment
Intervention
No. of arms
Purpose of intervention
Type of intervention
Interventions/Control_1
Interventions/Control_2
Interventions/Control_3
Interventions/Control_4
Interventions/Control_5
Interventions/Control_6
Interventions/Control_7
Interventions/Control_8
Interventions/Control_9
Interventions/Control_10
Eligibility
Age-lower limit
| 20 | years-old | <= |
Age-upper limit
| Not applicable |
Gender
Male and Female
Key inclusion criteria
Subjects who underwent MRI or MRI and PET scans in existing studies conducted by QST targeting healthy individuals and those with neurodegenerative and psychiatric disorders.
Key exclusion criteria
1)Cases where the research subject or their representative refused to allow their data to be used for secondary research when the existing research was explained.
2)Cases where the research subject or their representative refused to allow their data to be used for this research when information about this research was disclosed.
3)Cases where there was missing data that affected data analysis.
Target sample size
2370
Research contact person
Name of lead principal investigator
| 1st name | MARI |
| Middle name | |
| Last name | MIYATA |
Organization
National Institutes for Quantum Science and Technology
Division name
Advanced Neuroimaging Center
Zip code
263-8555
Address
4-9-1 Anagawa, Inage-ku, Chiba
TEL
0432063251
miyata.mari@qst.go.jp
Public contact
Name of contact person
| 1st name | MARI |
| Middle name | |
| Last name | MIYATA |
Organization
National Institutes for Quantum Science and Technology
Division name
Advanced Neuroimaging Center
Zip code
263-8555
Address
4-9-1 Anagawa, Inage-ku, Chiba
TEL
0432063251
Homepage URL
miyata.mari@qst.go.jp
Sponsor or person
Institute
National Institutes for Quantum Science and Technology
Institute
Department
Personal name
Funding Source
Organization
NoneNational Institutes for Quantum Science and Technology
Organization
Division
Category of Funding Organization
Other
Nationality of Funding Organization
Other related organizations
Co-sponsor
Name of secondary funder(s)
IRB Contact (For public release)
Organization
Natioanal institute of
Address
4-9-1 Anagawa, Inage-ku, Chiba
Tel
0432064713
miyata.mari@qst.go.jp
Secondary IDs
Secondary IDs
NO
Study ID_1
Org. issuing International ID_1
Study ID_2
Org. issuing International ID_2
IND to MHLW
Institutions
Institutions
Other administrative information
Date of disclosure of the study information
| 2025 | Year | 07 | Month | 23 | Day |
Related information
URL releasing protocol
Publication of results
Unpublished
Result
URL related to results and publications
Number of participants that the trial has enrolled
Results
Results date posted
Results Delayed
Results Delay Reason
Date of the first journal publication of results
Baseline Characteristics
Participant flow
Adverse events
Outcome measures
Plan to share IPD
IPD sharing Plan description
Progress
Recruitment status
Enrolling by invitation
Date of protocol fixation
| 2024 | Year | 07 | Month | 01 | Day |
Date of IRB
| 2025 | Year | 07 | Month | 15 | Day |
Anticipated trial start date
| 2025 | Year | 07 | Month | 15 | Day |
Last follow-up date
| 2030 | Year | 03 | Month | 31 | Day |
Date of closure to data entry
Date trial data considered complete
Date analysis concluded
Other
Other related information
MRI markers related to brain microstructure, brain deposits and brain function will be obtained at QST and joint research institutions, and disease groups will be compared with healthy groups. The correlation between these MRI markers and PET accumulation , blood biomarkers, neuropsychological tests, and clinical findings will then be evaluated.
Management information
Registered date
| 2025 | Year | 07 | Month | 23 | Day |
Last modified on
| 2025 | Year | 07 | Month | 23 | Day |
Link to view the page
Value
https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000066974
