Unique ID issued by UMIN | UMIN000058347 |
---|---|
Receipt number | R000066700 |
Scientific Title | Molecular pathological analysis of muscle layers in esophageal motility disorders |
Date of disclosure of the study information | 2025/07/02 |
Last modified on | 2025/07/02 14:55:58 |
Esophageal pathology and integrated correlates using POEM-based obtained esophageal muscle
EPIC-POEM
Molecular pathological analysis of muscle layers in esophageal motility disorders
Molecular pathological analysis of muscle layers in esophageal motility disorders
Japan |
esophageal motility disorders
Gastroenterology |
Others
YES
In this study, during POEM (Peroral Endoscopic Myotomy) for patients with esophageal motility disorders, endoscopic biopsies of the endoluminal muscles of the esophageal body, approximately 2 mm in size, are obtained from three locations (entry, middle, and LES). The obtained tissues are subjected to RNA sequencing and the results of RNA sequencing and immunostaining will be compared with the results of esophageal manometry. The purpose of this study is to elucidate the molecular pathological mechanisms of individual findings of esophageal manometry.
Others
If the results of this study reveal molecular pathological abnormalities corresponding to individual findings of esophageal manometry, it may provide new diagnostic methods and treatment options for patients with esophageal motility disorders.
Abnormal findings (normal contraction, excessive contraction, contraction failure, and relaxation failure) of the esophageal manometry at the site of collection will be compared with the results of the RNA sequencing test and immunostaining results.
Observational
18 | years-old | <= |
90 | years-old | > |
Male and Female
1) Patients with esophageal motility disorder who have already undergone or are scheduled to undergo esophageal intra-esophageal manometry who are attending or hospitalized at Okayama University Hospital and who will undergo POEM between the date of approval by the head of the research institution and December 31, 2028
2) Patients who can obtain free and voluntary written consent for research participation from the patient
3) Patients between 18 and 90 years of age at the time consent is obtained
None
50
1st name | Masaya |
Middle name | |
Last name | Iwamuro |
Okayama University Hospital
Department of Gastroenterology and Hepatology
700-8558
2-5-1 Shikata-cho, Kita-Ku, Okayama, Japan
+81-86-235-7219
pr145h2k@s.okayama-u.ac.jp
1st name | Shoichiro |
Middle name | |
Last name | Hirata |
Okayama University Hospital
Department of Gastroenterology and Hepatology
700-8558
2-5-1 Shikata-cho, Kita-Ku, Okayama, Japan
+81-86-235-7219
p6q09uf6@s.okayama-u.ac.jp
Okayama University
None
Other
Okayama University Hospital
2-5-1 Shikata-cho, Kita-Ku, Okayama, Japan
+81-86-235-7219
p6q09uf6@s.okayama-u.ac.jp
NO
2025 | Year | 07 | Month | 02 | Day |
Unpublished
Open public recruiting
2025 | Year | 06 | Month | 20 | Day |
2025 | Year | 06 | Month | 20 | Day |
2025 | Year | 07 | Month | 02 | Day |
2028 | Year | 12 | Month | 31 | Day |
None
2025 | Year | 07 | Month | 02 | Day |
2025 | Year | 07 | Month | 02 | Day |
Value
https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000066700