UMIN-CTR Clinical Trial
| Unique ID issued by UMIN | UMIN000057759 |
|---|---|
| Receipt number | R000066012 |
| Scientific Title | A Randomized Controlled Trial Evaluating the Effects of Basic Five-Taste Pairing Training and Umami Taste Recall Training |
| Date of disclosure of the study information | 2025/05/02 |
| Last modified on | 2025/05/07 09:07:51 |
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Basic information
Public title
A Randomized Controlled Trial Evaluating the Effects of Basic Five-Taste Pairing Training and Umami Taste Recall Training
Acronym
A Randomized Controlled Trial Evaluating the Effects of Basic Five-Taste Pairing Training and Umami Taste Recall Training
Scientific Title
A Randomized Controlled Trial Evaluating the Effects of Basic Five-Taste Pairing Training and Umami Taste Recall Training
Scientific Title:Acronym
A Randomized Controlled Trial Evaluating the Effects of Basic Five-Taste Pairing Training and Umami Taste Recall Training
Region
| Japan |
Condition
Condition
Taste dysfunction
Classification by specialty
| Adult |
Classification by malignancy
Others
Genomic information
NO
Objectives
Narrative objectives1
1. Comparison of the Effects of Umami Taste Recall Training and Basic Five-Taste Pairing Training
2. Investigation of the Taste Discrimination Mechanisms of Monosodium Glutamate (MSG), Inosine Monophosphate (IMP), and Guanosine Monophosphate (GMP)
Basic objectives2
Efficacy
Basic objectives -Others
Trial characteristics_1
Trial characteristics_2
Developmental phase
Assessment
Primary outcomes
1. Whether taste recognition thresholds for the five basic tastes improve through pairing training
2. Improvement in the ability to discriminate among three types of umami and salty taste
Key secondary outcomes
Base
Study type
Interventional
Study design
Basic design
Parallel
Randomization
Randomized
Randomization unit
Individual
Blinding
Open -no one is blinded
Control
No treatment
Stratification
Dynamic allocation
Institution consideration
Blocking
YES
Concealment
Intervention
No. of arms
2
Purpose of intervention
Treatment
Type of intervention
| Other |
Interventions/Control_1
1 Basic Five Tastes
Three days of taste pairing training will be conducted.
2 Umami taste
Three days of taste recall training will be conducted using NaCl, monosodium glutamate, disodium inosinate, and disodium guanylate.
Interventions/Control_2
1. Basic Five Tastes
Taste recognition thresholds will be measured only on Day 1 and Day 4, without conducting the three-day pairing training.
2. Umami
Umami taste recognition thresholds will be measured only on Day 1 and Day 4, without conducting the umami taste recall training.
Interventions/Control_3
Interventions/Control_4
Interventions/Control_5
Interventions/Control_6
Interventions/Control_7
Interventions/Control_8
Interventions/Control_9
Interventions/Control_10
Eligibility
Age-lower limit
| 20 | years-old | <= |
Age-upper limit
| 65 | years-old | >= |
Gender
Male and Female
Key inclusion criteria
1.Healthy adult men and women aged 20 to 64
2.No history of taste disorders and not currently diagnosed with any taste abnormality by a physician
3.Individuals who have provided written informed consent to participate in the study
Key exclusion criteria
1.Individuals deemed unsuitable for participation in the study by a physician
2.Individuals who declined to participate in the study
3.Individuals with allergies to sucrose, sodium chloride, L(+)-tartaric acid, quinine hydrochloride, monosodium glutamate (MSG), disodium inosinate (IMP), or disodium guanylate (GMP)
4.Smokers
Target sample size
76
Research contact person
Name of lead principal investigator
| 1st name | Satoru |
| Middle name | |
| Last name | Ebihara |
Organization
Tohoku University Graduate School of medicine
Division name
Department of Rehabilitation Medicine
Zip code
9808574
Address
Seiryo-machi 1-1, Aoba-ku, Sendai
TEL
022-717-8574
satoru.ebihara.c4@tohoku.ac.jp
Public contact
Name of contact person
| 1st name | Midori |
| Middle name | |
| Last name | Miyagi |
Organization
Tohoku University Graduate School of Medicine
Division name
Department of Rehabilitation Medicine
Zip code
9808574
Address
Seiryo-machi 1-1, Aoba-ku sendai
TEL
022-717-7353
Homepage URL
midori.miyagi.b5@tohoku.ac.jp
Sponsor or person
Institute
Tohoku University
Institute
Department
Personal name
Funding Source
Organization
Tohoku University
Organization
Division
Category of Funding Organization
Other
Nationality of Funding Organization
Other related organizations
Co-sponsor
Name of secondary funder(s)
IRB Contact (For public release)
Organization
Ethics Committee Tohoku University Graduate School of Medicine
Address
2-1 Seiryo-machi, Aoba-ku, Sendai, Miyagi, 980-8575, Japan
Tel
022-728-4105
ec-med@grp.tohoku.ac.jp
Secondary IDs
Secondary IDs
NO
Study ID_1
Org. issuing International ID_1
Study ID_2
Org. issuing International ID_2
IND to MHLW
Institutions
Institutions
Other administrative information
Date of disclosure of the study information
| 2025 | Year | 05 | Month | 02 | Day |
Related information
URL releasing protocol
Publication of results
Unpublished
Result
URL related to results and publications
Number of participants that the trial has enrolled
Results
Results date posted
Results Delayed
Results Delay Reason
Date of the first journal publication of results
Baseline Characteristics
Participant flow
Adverse events
Outcome measures
Plan to share IPD
IPD sharing Plan description
Progress
Recruitment status
Preinitiation
Date of protocol fixation
| 2025 | Year | 05 | Month | 02 | Day |
Date of IRB
Anticipated trial start date
| 2025 | Year | 06 | Month | 15 | Day |
Last follow-up date
| 2030 | Year | 06 | Month | 15 | Day |
Date of closure to data entry
Date trial data considered complete
Date analysis concluded
Other
Other related information
Management information
Registered date
| 2025 | Year | 05 | Month | 02 | Day |
Last modified on
| 2025 | Year | 05 | Month | 07 | Day |
Link to view the page
Value
https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000066012
