UMIN-CTR Clinical Trial
| Unique ID issued by UMIN | UMIN000055584 |
|---|---|
| Receipt number | R000063519 |
| Scientific Title | The impact of EGFR mutations on outcomes after chemoradiotherapy for locally advanced non small cell lung cancer: a systematic review and meta-analysis |
| Date of disclosure of the study information | 2024/09/24 |
| Last modified on | 2024/09/22 17:56:43 |
* This page includes information on clinical trials registered in UMIN clinical trial registed system.
* We don't aim to advertise certain products or treatments
Basic information
Public title
The outcome of chemoradiotherapy for NSCLC - EGFR mutant vs wild-type -
Acronym
The outcome of chemoradiotherapy for NSCLC - EGFR mutant vs wild-type -
Scientific Title
The impact of EGFR mutations on outcomes after chemoradiotherapy for locally advanced non small cell lung cancer: a systematic review and meta-analysis
Scientific Title:Acronym
The impact of EGFR mutations on outcomes after CRT for LA-NSCLC: a systematic review and meta-analysis
Region
| Japan |
Condition
Condition
non small cell lung cancer
Classification by specialty
| Pneumology | Radiology |
Classification by malignancy
Malignancy
Genomic information
NO
Objectives
Narrative objectives1
To evaluate the influence of EGFR mutations on survival outcomes in patients with locally advanced non small cell lung cancer treated with chemoradiotherapy
Basic objectives2
Others
Basic objectives -Others
The difference of survival outcomes after chemoradiotherapy for locally advanced non-small cell lung cancer
Trial characteristics_1
Trial characteristics_2
Developmental phase
Assessment
Primary outcomes
progression-free survival and overall survival
Key secondary outcomes
post-progression survival, patterns of disease progression
Base
Study type
Others,meta-analysis etc
Study design
Basic design
Randomization
Randomization unit
Blinding
Control
Stratification
Dynamic allocation
Institution consideration
Blocking
Concealment
Intervention
No. of arms
Purpose of intervention
Type of intervention
Interventions/Control_1
Interventions/Control_2
Interventions/Control_3
Interventions/Control_4
Interventions/Control_5
Interventions/Control_6
Interventions/Control_7
Interventions/Control_8
Interventions/Control_9
Interventions/Control_10
Eligibility
Age-lower limit
| Not applicable |
Age-upper limit
| Not applicable |
Gender
Male and Female
Key inclusion criteria
Inclusion criteria were: (i) studies reporting survival outcomes following CRT for LA-NSCLC; (ii) studies comparing survival outcomes between EGFR mutant
Key exclusion criteria
Exclusion criteria were: (i) non-English publications; (ii) studies including patients receiving targeted therapy or immunotherapy; (iii) studies involving radiotherapy alone.
Target sample size
Research contact person
Name of lead principal investigator
| 1st name | Satoru |
| Middle name | |
| Last name | Ochiai |
Organization
JAPANESE RED CROSS ISE HOSPITAL
Division name
Department of Radiation Oncology
Zip code
516-8512
Address
Ise Red Cross Hospital 1-471-2 Funae, Ise City, Mie Prefecture, Japan
TEL
0596-28-2171
sochiamn@gmail.com
Public contact
Name of contact person
| 1st name | Satoru |
| Middle name | |
| Last name | Ochiai |
Organization
JAPANESE RED CROSS ISE HOSPITAL
Division name
Department of Radiation Oncology
Zip code
516-8512
Address
Ise Red Cross Hospital 1-471-2 Funae, Ise City, Mie Prefecture, Japan
TEL
0596-28-2171
Homepage URL
sochiamn@gmail.com
Sponsor or person
Institute
JAPANESE RED CROSS ISE HOSPITAL, Department of Radiation Oncology, Satoru Ochiai
Institute
Department
Personal name
Funding Source
Organization
JAPANESE RED CROSS ISE HOSPITAL, Department of Radiation Oncology, Satoru Ochiai
Organization
Division
Category of Funding Organization
Other
Nationality of Funding Organization
Other related organizations
Co-sponsor
Name of secondary funder(s)
IRB Contact (For public release)
Organization
JAPANESE RED CROSS ISE HOSPITAL, Department of Radiation Oncology, Satoru Ochiai
Address
1-471-2 Funae, Ise City, Mie Prefecture, Japan
Tel
0596-28-2171
sochiamn@gmail.com
Secondary IDs
Secondary IDs
NO
Study ID_1
Org. issuing International ID_1
Study ID_2
Org. issuing International ID_2
IND to MHLW
Institutions
Institutions
Other administrative information
Date of disclosure of the study information
| 2024 | Year | 09 | Month | 24 | Day |
Related information
URL releasing protocol
Publication of results
Unpublished
Result
URL related to results and publications
Number of participants that the trial has enrolled
Results
Results date posted
Results Delayed
Results Delay Reason
Date of the first journal publication of results
Baseline Characteristics
Participant flow
Adverse events
Outcome measures
Plan to share IPD
IPD sharing Plan description
Progress
Recruitment status
Preinitiation
Date of protocol fixation
| 2024 | Year | 09 | Month | 20 | Day |
Date of IRB
Anticipated trial start date
| 2024 | Year | 10 | Month | 01 | Day |
Last follow-up date
| 2024 | Year | 10 | Month | 31 | Day |
Date of closure to data entry
Date trial data considered complete
Date analysis concluded
Other
Other related information
We will conduct a systematic review to identify studies evaluating survival outcomes after CRT for locally advanced non-small cell lung cancer, comparing EGFR mutant and wild-type using Kaplan-Meier curves.
In the literature search, we will search through PubMed, EMBASE, and Web of Science.
The search keywords includes "chemoradiotherapy OR chemoradiation" AND "lung" AND "epidermal growth factor OR EGFR"
We plan to include studies reported up to September 2024.
Management information
Registered date
| 2024 | Year | 09 | Month | 22 | Day |
Last modified on
| 2024 | Year | 09 | Month | 22 | Day |
Link to view the page
Value
https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000063519
