UMIN-CTR Clinical Trial
| Unique ID issued by UMIN | UMIN000060486 |
|---|---|
| Receipt number | R000062932 |
| Scientific Title | Verification of the effectiveness of strength training for muscle hypertrophy by metabolic stress |
| Date of disclosure of the study information | 2026/03/31 |
| Last modified on | 2026/01/27 16:12:41 |
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Basic information
Public title
Effectiveness verification of a new strength training focused on blood flow restriction
Acronym
Verification of effectiveness of new strength training
Scientific Title
Verification of the effectiveness of strength training for muscle hypertrophy by metabolic stress
Scientific Title:Acronym
Verification of the effectiveness of strength training for muscle hypertrophy
Region
| Japan |
Condition
Condition
healthy adults
Classification by specialty
| Adult |
Classification by malignancy
Others
Genomic information
NO
Objectives
Narrative objectives1
The purpose of this study was to propose a new method of RT under blood flow restriction in muscles that combines isometric and isotonic contractions, which are conventionally used for strength training, and to clarify the physiological changes in metabolic stress and mechanical tension related to muscle hypertrophy with respect to this strength training. To clarify.
Basic objectives2
Efficacy
Basic objectives -Others
Trial characteristics_1
Trial characteristics_2
Developmental phase
Assessment
Primary outcomes
Electromyography (EMG) of the vastus lateralis muscle
Key secondary outcomes
1.Serum Insulin-like Growth Factor 1 (IGF-1) concentration
2.Muscle oxygenation dynamics of the vastus lateralis muscle measured by NIRS
Base
Study type
Interventional
Study design
Basic design
Parallel
Randomization
Randomized
Randomization unit
Individual
Blinding
Open -no one is blinded
Control
Active
Stratification
Dynamic allocation
Institution consideration
Blocking
Concealment
Intervention
No. of arms
3
Purpose of intervention
Educational,Counseling,Training
Type of intervention
| Other |
Interventions/Control_1
Low-Intensity Slow Training (LST) Group Description: Participants performed resistance training at an intensity of 50% 1RM. The movement cycle consisted of a 3-second extension, a 1-second pause, and a 3-second flexion (slow movement). A "non-lock" technique was employed to avoid complete extension and flexion, maintaining constant muscle tension throughout the 8 repetitions.
Interventions/Control_2
High-Load Training (HL) Group Description: Participants performed resistance training at an intensity of 80% 1RM. The movement speed was controlled at 1 second for extension and 1 second for flexion (normal speed). The exercise was performed through a full range of motion (Full ROM) for 8 repetitions, with strict control to prevent compensatory movements.
Interventions/Control_3
Combined Training (CB) Group Description: Participants performed a combined training protocol at an intensity of 40% 1RM. The protocol consisted of a 20-second isometric contraction at a knee joint angle of approximately 70 degrees, immediately followed by 8 repetitions of partial range-of-motion movements centered around the same angle, performed at a high tempo of 100 bpm.
Interventions/Control_4
Interventions/Control_5
Interventions/Control_6
Interventions/Control_7
Interventions/Control_8
Interventions/Control_9
Interventions/Control_10
Eligibility
Age-lower limit
| 18 | years-old | <= |
Age-upper limit
| 24 | years-old | >= |
Gender
Male
Key inclusion criteria
able-bodied university student
Key exclusion criteria
Those with a history of orthopedic disease in the lower extremities
Those with regular exercise or training habits
Have limited range of motion in each joint of the lower limb that would interfere with training
Target sample size
50
Research contact person
Name of lead principal investigator
| 1st name | Tomonari |
| Middle name | |
| Last name | Sugano |
Organization
Fukui Health Science University
Division name
Faculty of Health Science, Department of Rehabilitation, Division of Physical Therapy
Zip code
9103190
Address
55 Egami-cho 13-1, Fukui-City, Fukui
TEL
0776592201
t.sugano@fukui-hsu.ac.jp
Public contact
Name of contact person
| 1st name | Tomonari |
| Middle name | |
| Last name | Sugano |
Organization
Fukui Health Science University
Division name
Faculty of Health Science, Department of Rehabilitation, Division of Physical Therapy
Zip code
9103190
Address
55 Egami-cho 13-1, Fukui-City, Fukui
TEL
0776592201
Homepage URL
t.sugano@fukui-hsu.ac.jp
Sponsor or person
Institute
Fukui Health Science University
Institute
Department
Personal name
Funding Source
Organization
Fukui Health Science University
Organization
Division
Category of Funding Organization
Other
Nationality of Funding Organization
Other related organizations
Co-sponsor
Name of secondary funder(s)
IRB Contact (For public release)
Organization
Fukui Health Science University
Address
55 Egami-cho 13-1, Fukui-City, Fukui
Tel
0776592201
t.sugano@fukui-hsu.ac.jp
Secondary IDs
Secondary IDs
NO
Study ID_1
Org. issuing International ID_1
Study ID_2
Org. issuing International ID_2
IND to MHLW
Institutions
Institutions
Other administrative information
Date of disclosure of the study information
| 2026 | Year | 03 | Month | 31 | Day |
Related information
URL releasing protocol
Publication of results
Unpublished
Result
URL related to results and publications
Number of participants that the trial has enrolled
50
Results
Results date posted
Results Delayed
Results Delay Reason
Date of the first journal publication of results
Baseline Characteristics
Participant flow
Adverse events
Outcome measures
Plan to share IPD
IPD sharing Plan description
Progress
Recruitment status
Completed
Date of protocol fixation
| 2024 | Year | 07 | Month | 01 | Day |
Date of IRB
| 2024 | Year | 08 | Month | 09 | Day |
Anticipated trial start date
| 2024 | Year | 09 | Month | 01 | Day |
Last follow-up date
| 2025 | Year | 11 | Month | 01 | Day |
Date of closure to data entry
Date trial data considered complete
Date analysis concluded
Other
Other related information
Management information
Registered date
| 2026 | Year | 01 | Month | 27 | Day |
Last modified on
| 2026 | Year | 01 | Month | 27 | Day |
Link to view the page
Value
https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000062932
