UMIN-CTR Clinical Trial
| Unique ID issued by UMIN | UMIN000054584 |
|---|---|
| Receipt number | R000062328 |
| Scientific Title | Associattion of Skeletal Muscle Fatty Degeneration with Falls and Fall Risk Factors in Older Adults:A systematic review |
| Date of disclosure of the study information | 2024/06/14 |
| Last modified on | 2025/06/02 22:52:44 |
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Basic information
Public title
Associattion of Skeletal Muscle Fatty Degeneration with Falls and Fall Risk Factors in Older Adults:A systematic review
Acronym
Associattion of Skeletal Muscle Fatty Degeneration with Falls and Fall Risk Factors in Older Adults:A systematic review
Scientific Title
Associattion of Skeletal Muscle Fatty Degeneration with Falls and Fall Risk Factors in Older Adults:A systematic review
Scientific Title:Acronym
Associattion of Skeletal Muscle Fatty Degeneration with Falls and Fall Risk Factors in Older Adults:A systematic review
Region
| Japan |
Condition
Condition
Older Adults, Musculoskeletal disease, Respiratory disease, Cardiovascular disease
Classification by specialty
| Rehabilitation medicine |
Classification by malignancy
Others
Genomic information
NO
Objectives
Narrative objectives1
The purpose of this review is to determine the association between skeletal muscle fatty degeneration and falls and fall risk factors in older adults.
Basic objectives2
Others
Basic objectives -Others
The purpose of this review is to determine the association between skeletal muscle fatty degeneration and falls and fall risk factors in older adults.
Trial characteristics_1
Trial characteristics_2
Developmental phase
Assessment
Primary outcomes
falls
Key secondary outcomes
Physical function performance (walking speed, muscle strength, balance)
Base
Study type
Others,meta-analysis etc
Study design
Basic design
Randomization
Randomization unit
Blinding
Control
Stratification
Dynamic allocation
Institution consideration
Blocking
Concealment
Intervention
No. of arms
Purpose of intervention
Type of intervention
Interventions/Control_1
Interventions/Control_2
Interventions/Control_3
Interventions/Control_4
Interventions/Control_5
Interventions/Control_6
Interventions/Control_7
Interventions/Control_8
Interventions/Control_9
Interventions/Control_10
Eligibility
Age-lower limit
| 40 | years-old | <= |
Age-upper limit
| Not applicable |
Gender
Male and Female
Key inclusion criteria
(1)ages 40 and over.
(2)the fatty degeneration of skeletal muscle was been quantified.
(3)the incidence of falls has been evaluated, or a quantitative assessment of physical function pertinent to fall risk factors has been undertaken.
(4)the paper was an observational study.
(5)the paper was an original article.
(6)the paper was written in English or Japanese.
Key exclusion criteria
(1)participants with neuromuscular diseases
(2)participants with lower limb amputation
Target sample size
Research contact person
Name of lead principal investigator
| 1st name | Atsushi |
| Middle name | |
| Last name | Shinonaga |
Organization
Hiroshima University
Division name
Graduate School of Humanities and Social Sciences
Zip code
739-0046
Address
1-1-1 Kagamiyama, Higashi-Hiroshima City, Hiroshima, Japan
TEL
082-424-6306
a-shino-reha@hp.kawasaki-m.ac.jp
Public contact
Name of contact person
| 1st name | Atsushi |
| Middle name | |
| Last name | Shinonaga |
Organization
Hiroshima University
Division name
Graduate School of Humanities and Social Sciences
Zip code
739-0046
Address
1-1-1 Kagamiyama, Higashi-Hiroshima City, Hiroshima, Japan
TEL
082-424-6306
Homepage URL
a-shino-reha@hp.kawasaki-m.ac.jp
Sponsor or person
Institute
Hiroshima University
Institute
Department
Personal name
Funding Source
Organization
None
Organization
Division
Category of Funding Organization
Self funding
Nationality of Funding Organization
Other related organizations
Co-sponsor
Name of secondary funder(s)
IRB Contact (For public release)
Organization
Graduate school of Humanities and Social Sciences, Hiroshima University
Address
1-7-1 Kagamiyama, Higashi-Hiroshima City, Hiroshima
Tel
082-424-6306
a-shino-reha@hp.kawasaki-m.ac.jp
Secondary IDs
Secondary IDs
NO
Study ID_1
Org. issuing International ID_1
Study ID_2
Org. issuing International ID_2
IND to MHLW
Institutions
Institutions
Other administrative information
Date of disclosure of the study information
| 2024 | Year | 06 | Month | 14 | Day |
Related information
URL releasing protocol
Publication of results
Published
Result
URL related to results and publications
Number of participants that the trial has enrolled
97
Results
Our systematic review integrated 97 observational studies to comprehensively examine the association between fatty infiltration of muscle, falls, and fall-related outcomes. As a result, a number of studies have shown that fatty infiltration of muscle may be associated with falls. Similarly, fatty infiltration of muscle has been shown to be associated with a poorer variety of fall-related outcomes.
Results date posted
| 2025 | Year | 06 | Month | 02 | Day |
Results Delayed
Results Delay Reason
Date of the first journal publication of results
Baseline Characteristics
Participant flow
Adverse events
Outcome measures
Plan to share IPD
IPD sharing Plan description
Progress
Recruitment status
Main results already published
Date of protocol fixation
| 2024 | Year | 06 | Month | 14 | Day |
Date of IRB
| 2024 | Year | 06 | Month | 14 | Day |
Anticipated trial start date
| 2024 | Year | 06 | Month | 14 | Day |
Last follow-up date
| 2025 | Year | 05 | Month | 31 | Day |
Date of closure to data entry
Date trial data considered complete
Date analysis concluded
Other
Other related information
The following electronic databases are searched in June 2024: PubMed, the Cochrane Central Register of Controlled Trials (CENTRAL), Web of science, and the Cumulative Index to Nursing and Allied Health Literature (CINAHL) and Igaku Chuo Zasshi (ICHUSHI). The search strategy is a combination of free text words and Medical Subject Headings (MeSH) terms. The exposure factor will be skeletal muscle fatty degeneration. Outcomes will be falls, physical function, gait, strength, and balance. For each concept, synonyms and Medical Subject Headings (MeSH) terms are combined with the OR operator.
Management information
Registered date
| 2024 | Year | 06 | Month | 06 | Day |
Last modified on
| 2025 | Year | 06 | Month | 02 | Day |
Link to view the page
Value
https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000062328
