Unique ID issued by UMIN | UMIN000053977 |
---|---|
Receipt number | R000061614 |
Scientific Title | Postoperative delirium prevention and analgesic effects of continuous postoperative administration of dexmedetomidine for craniotomy |
Date of disclosure of the study information | 2024/04/01 |
Last modified on | 2024/03/26 22:13:19 |
Postoperative delirium prevention and analgesic effects of continuous postoperative administration of dexmedetomidine for craniotomy
Delirium prevention and analgesic effect of dexmedetomidine
Postoperative delirium prevention and analgesic effects of continuous postoperative administration of dexmedetomidine for craniotomy
Delirium prevention and analgesic effect of dexmedetomidine
Japan |
Neurosurgery craniotomy
Anesthesiology | Neurosurgery |
Malignancy
NO
It has been suggested that intraoperative dexmedetomidine administration may be effective for postoperative analgesia. In neurosurgery, the use of postoperative opioids is not necessarily appropriate because it causes side effects such as nausea and delirium. One candidate analgesic to replace opioids is dexmedetomidine, and the purpose of this study is to demonstrate the analgesic effect of its postoperative administration.
Additionally, if dexmedetomidine's sedative effect can prevent delirium and exert analgesic effect, it is considered to be a useful analgesic alternative to opioids.
Efficacy
Analgesic effect of dexmedetomidine
Delirium prevention
Interventional
Parallel
Randomized
Individual
Double blind -all involved are blinded
No treatment
2
Treatment
Medicine |
Dexmedetomidine administration group
Physiological saline administration group
20 | years-old | <= |
Not applicable |
Male and Female
Patients undergoing craniotomy
emergency surgery patient
Patients with ASA-PS3 or higher
Patients with contraindications to haloperidol, such as Parkinson's disease
Patients with renal impairment and contraindication to NSAIDs
Patients who are allergic to other drugs used
Patients who cannot consent
minor
30
1st name | Akiyuki |
Middle name | |
Last name | Sakamoto |
Shinonoi general hospital
Anesthesiology
3888004
666-1 Ai, Shinonoi, Nagano city, Nagano prefecture
0262922261
akiyuki@shinonoi-hp.jp
1st name | Akiyuki |
Middle name | |
Last name | Sakamoto |
shinonoi general hospital
Anesthesiology
3888004
666-1 Ai, Shinonoi, Nagano city, Nagano prefecture
0262922261
akiyuki@shinonoi-hp.jp
Shinonoi general hospital
Nothing
Other
Shinonoi general hospital
666-1 Ai, Shinonoi, Nagano city, Nagano prefecture
0262922261
akiyuki@shinonoi-hp.jp
NO
2024 | Year | 04 | Month | 01 | Day |
Unpublished
Preinitiation
2024 | Year | 01 | Month | 10 | Day |
2024 | Year | 04 | Month | 01 | Day |
2027 | Year | 03 | Month | 31 | Day |
2024 | Year | 03 | Month | 26 | Day |
2024 | Year | 03 | Month | 26 | Day |
Value
https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000061614