Unique ID issued by UMIN | UMIN000052316 |
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Receipt number | R000059606 |
Scientific Title | Association between posaconazole use and hypokalemia: A Systematic Review and Meta-Analysis |
Date of disclosure of the study information | 2023/09/30 |
Last modified on | 2024/05/14 09:52:01 |
Association between posaconazole use and hypokalemia: A Systematic Review and Meta-Analysis
Association between posaconazole use and hypokalemia
Association between posaconazole use and hypokalemia: A Systematic Review and Meta-Analysis
Association between posaconazole use and hypokalemia: A Systematic Review and Meta-Analysis
Japan |
Patients with prophylactic administration of posaconazole for invasive fungal infections in severely immunocompromised states such as hematopoietic stem cell transplantation or hematologic malignancies where neutropenia is predicted
Patients treated with posaconazole for invasive aspergillosis, fusariosis, mucormycosis, coccidioidosis, chromoblastomycosis, and mycetoma
Patients treated with posaconazole for oropharyngeal candidiasis
The trial will be a randomised controlled trial with the above subjects
Infectious disease |
Others
NO
This study investigates the association between posaconazole use and hypokalemia
Safety
Confirmatory
Pragmatic
Not applicable
hypokalemia
<Secondary outcomes>
rhabdomyolysis, pseudohyperaldosteronism, hypertension
<Subgroup Analysis>
(1) Prophylactic administration of posaconazole for invasive fungal infections in severe immunodeficiency states such as hematopoietic stem cell transplantation or hematologic malignancies where neutropenia is expected
(2) Fungal infections (invasive aspergillosis, fusariasis, mucormycosis, coccidioidosis, chromoblastomycosis, and mycetoma)
(3) Investigate with antifungal agents or placebo, respectively
Subgroup analysis will be performed in each of the above.
<Sensitivity analysis>
Meta-analysis will be performed by excluding trials with a risk of bias for "High" in ROB2.
Others,meta-analysis etc
13 | years-old | <= |
Not applicable |
Male and Female
Patients with prophylactic administration of posaconazole for invasive fungal infections in severely immunocompromised states such as hematopoietic stem cell transplantation or hematologic malignancies where neutropenia is predicted
Patients treated with posaconazole for invasive aspergillosis, fusariosis, mucormycosis, coccidioidosis, chromoblastomycosis, and mycetoma
Patients treated with posaconazole for oropharyngeal candidiasis
Letters/correspondence, case reports, relevant reviews, no controlled arm, unclear outcomes
1st name | Yuki |
Middle name | |
Last name | Nakano |
Saiseikai Futsukaichi Hospital
Department of pharmacy
818-0058
3-13-1, Yumachi, Chikushino City, Fukuoka
092-923-1551
y-nakano@saiseikai-futsukaichi.org
1st name | Yuki |
Middle name | |
Last name | Nakano |
Saiseikai Futsukaichi Hospital
Department of pharmacy
818-0058
3-13-1, Yumachi, Chikushino City, Fukuoka
092-923-1551
y-nakano@saiseikai-futsukaichi.org
Saiseikai Futsukaichi Hospital
Yuki Nakano
Saiseikai Futsukaichi Hospital
Self funding
Japan
Saiseikai Futsukaichi Hospital Institutional review board
3-13-1, Yumachi, Chikushino City, Fukuoka
092-923-1551
a-hayashi@saiseikai-futsukaichi.org
NO
2023 | Year | 09 | Month | 30 | Day |
Unpublished
Open public recruiting
2023 | Year | 09 | Month | 30 | Day |
2024 | Year | 02 | Month | 29 | Day |
2023 | Year | 09 | Month | 30 | Day |
2024 | Year | 02 | Month | 28 | Day |
Primary endpoints
Hypokalemia
Secondary endpoints
Rhabdomyolysis
Pseudohyperaldosteronism
Hypertension
2023 | Year | 09 | Month | 26 | Day |
2024 | Year | 05 | Month | 14 | Day |
Value
https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000059606
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