Unique ID issued by UMIN | UMIN000051537 |
---|---|
Receipt number | R000058794 |
Scientific Title | The effect of an angiotensin receptor-neprilysin inhibitor to blood pressure and sympathoadrenal responses during mental arithmetic stress in patients with essential hypertension |
Date of disclosure of the study information | 2023/07/06 |
Last modified on | 2023/07/06 13:04:11 |
The effect of an angiotensin receptor-neprilysin inhibitor to blood pressure and sympathoadrenal responses during mental arithmetic stress in patients with essential hypertension
The effect of an angiotensin receptor-neprilysin inhibitor to mental arithmetic stress in patients with essential hypertension
The effect of an angiotensin receptor-neprilysin inhibitor to blood pressure and sympathoadrenal responses during mental arithmetic stress in patients with essential hypertension
The effect of an angiotensin receptor-neprilysin inhibitor to mental arithmetic stress in patients with essential hypertension
Japan |
essential hypertension
Cardiology | Nephrology |
Others
NO
To investigate the effects of an angiotensin receptor-neprilysin inhibitor, sacubitril-valsartan to blood pressure and sympathoadrenal responses during mental arithmetic stress in patients with essential hypertension
Efficacy
Changes in blood pressure and indices of sympathoadrenal system (plasma catecholamines, power spectrum analysis obtained from heart rate variability measured by Holter ECG) during mental arithmetic stress before and after treatment (sacubitril-valsartan or valsartan administration)
Interventional
Parallel
Randomized
Individual
Open -no one is blinded
Active
2
Treatment
Medicine |
Administration of sacubitril valsartan for one year
Administration of valsartan for one year
20 | years-old | <= |
70 | years-old | > |
Male and Female
1) Patient with untreated essential hypertensiont
2) Patient who is between 20 and 70 years old
3) Patient who can freely give consent under a good understanding of the explanation
1) Patient under 20 years old or over 70 years old
2) Patient receiving angiotensin converting enzyme or within 36 hours of its discontinuation
3) Diabetic patient receiving aliskiren fumarate
4) Patient with severe hepatic impairment (Child-Pugh class C)
5) Pregnant woman or woman who may be pregnant
6) Patient judged by the research physician to be unsuitable for inclusion
40
1st name | Tsutomu |
Middle name | |
Last name | Koike |
University of Toyama
The Second Department of Internal Medicine
930-0194
2630 Sugitani, Toyama, Toyama, Japan
076-434-7297
tkoike@med.u-toyama.ac.jp
1st name | Tsutomu |
Middle name | |
Last name | Koike |
University of Toyama
The Second Department of Internal Medicine
930-0194
2630 Sugitani, Toyama, Toyama, Japan
076-434-7297
tkoike@med.u-toyama.ac.jp
University of Toyama
University of Toyama
Self funding
Ethics Committee, University of Toyama
2630 Sugitani, Toyama, Toyama, Japan
076-434-7681
rinri@adm.u-toyama.ac.jp
NO
2023 | Year | 07 | Month | 06 | Day |
Unpublished
Enrolling by invitation
2023 | Year | 05 | Month | 24 | Day |
2023 | Year | 05 | Month | 24 | Day |
2023 | Year | 08 | Month | 01 | Day |
2027 | Year | 12 | Month | 31 | Day |
2023 | Year | 07 | Month | 06 | Day |
2023 | Year | 07 | Month | 06 | Day |
Value
https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000058794