UMIN-CTR Clinical Trial
| Unique ID issued by UMIN | UMIN000049959 |
|---|---|
| Receipt number | R000056899 |
| Scientific Title | Efficacy of Short-Course vs Long-Course Antibiotic Therapy for Community-Acquired Pneumonia:A Systematic Review and Meta-Analysis |
| Date of disclosure of the study information | 2023/01/04 |
| Last modified on | 2025/01/05 12:25:04 |
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Basic information
Public title
Efficacy of Short-Course vs Long-Course Antibiotic Therapy for Community-Acquired Pneumonia:A Systematic Review and Meta-Analysis
Acronym
Efficacy of Short-Course vs Long-Course Antibiotic Therapy for Community-Acquired Pneumonia
Scientific Title
Efficacy of Short-Course vs Long-Course Antibiotic Therapy for Community-Acquired Pneumonia:A Systematic Review and Meta-Analysis
Scientific Title:Acronym
Efficacy of Short-Course vs Long-Course Antibiotic Therapy for Community-Acquired Pneumonia:A Systematic Review and Meta-Analysis
Region
| Japan |
Condition
Condition
Community-acquired pneumonia
Classification by specialty
| Pneumology |
Classification by malignancy
Others
Genomic information
NO
Objectives
Narrative objectives1
We will conduct a systematic review and meta-analysis of the efficacy of short-term therapy (<= 7days) vs long-term therapy (>7 days) for community-acquired pneumonia.
Basic objectives2
Safety,Efficacy
Basic objectives -Others
Trial characteristics_1
Trial characteristics_2
Developmental phase
Not applicable
Assessment
Primary outcomes
Prognosis, clinical efficacy, relapse of pneumonia, hospital days, adverse events, cost
Key secondary outcomes
Base
Study type
Others,meta-analysis etc
Study design
Basic design
Randomization
Randomization unit
Blinding
Control
Stratification
Dynamic allocation
Institution consideration
Blocking
Concealment
Intervention
No. of arms
Purpose of intervention
Type of intervention
Interventions/Control_1
Interventions/Control_2
Interventions/Control_3
Interventions/Control_4
Interventions/Control_5
Interventions/Control_6
Interventions/Control_7
Interventions/Control_8
Interventions/Control_9
Interventions/Control_10
Eligibility
Age-lower limit
| 18 | years-old | <= |
Age-upper limit
| Not applicable |
Gender
Male and Female
Key inclusion criteria
Patients with community-acquired pneumonia aged 18 years or older.
Key exclusion criteria
Pediatric patients.
Target sample size
Research contact person
Name of lead principal investigator
| 1st name | Shotaro |
| Middle name | |
| Last name | Ide |
Organization
Nagasaki University Hospital
Division name
Infectious Diseases Experts Training Center
Zip code
8528501
Address
1-7-1, Sakamoto, Nagasaki-city, Nagasaki, Japan
TEL
095-819-7506
str-ide@nagasaki-u.ac.jp
Public contact
Name of contact person
| 1st name | Shotaro |
| Middle name | |
| Last name | Ide |
Organization
Nagasaki University Hospital
Division name
Infectious Diseases Experts Training Center
Zip code
8528501
Address
1-7-1, Sakamoto, Nagasaki-city, Nagasaki, Japan
TEL
095-819-7506
Homepage URL
str-ide@nagasaki-u.ac.jp
Sponsor or person
Institute
Japan Respiratory Society
Institute
Department
Personal name
Funding Source
Organization
None
Organization
Division
Category of Funding Organization
Other
Nationality of Funding Organization
Other related organizations
Co-sponsor
Name of secondary funder(s)
IRB Contact (For public release)
Organization
Japan Respiratory Society
Address
8-28-3, Hongo, Bunkyo-ku, Tokyo, Japan
Tel
03-5805-3553
info@jrs.or.jp
Secondary IDs
Secondary IDs
NO
Study ID_1
Org. issuing International ID_1
Study ID_2
Org. issuing International ID_2
IND to MHLW
Institutions
Institutions
長崎大学病院（長崎県）
Other administrative information
Date of disclosure of the study information
| 2023 | Year | 01 | Month | 04 | Day |
Related information
URL releasing protocol
Publication of results
Published
Result
URL related to results and publications
https://www.jrs.or.jp/publication/jrs_guidelines/20240319125656.html
Number of participants that the trial has enrolled
3077
Results
A total of 22 RCTs were analyzed. Short-term treatment showed no significant differences in mortality, cure rate, recurrence rate, or adverse event rate compared to standard treatment (>1 week). It reduced hospital stay by 0.85 days (not significant) and was reported to lower medical costs. The "Number of Participants" field reflects the number used in the mortality analysis.
Results date posted
| 2025 | Year | 01 | Month | 05 | Day |
Results Delayed
Results Delay Reason
Date of the first journal publication of results
| 2024 | Year | 04 | Month | 05 | Day |
Baseline Characteristics
Participant flow
Adverse events
Outcome measures
Plan to share IPD
IPD sharing Plan description
Progress
Recruitment status
Completed
Date of protocol fixation
| 2022 | Year | 08 | Month | 31 | Day |
Date of IRB
| 2022 | Year | 08 | Month | 31 | Day |
Anticipated trial start date
| 2022 | Year | 08 | Month | 31 | Day |
Last follow-up date
| 2024 | Year | 12 | Month | 31 | Day |
Date of closure to data entry
Date trial data considered complete
Date analysis concluded
Other
Other related information
A systematic search of the literature was conducted in accordance with the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analysis) statement. The Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE via PubMed, and medical journals were used as electronic databases. Other resources included the World Health Organization International Clinical Trials Platform Search Portal (ICTRP) and ClinicalTrials.gov. Review Manager 5.4 was used for meta-analysis. This systematic review was based on published literature and did not involve the collection or use of new data from human subjects. Therefore, it was not submitted for review by an Institutional Review Board (IRB). However, due to the requirements of the UMIN registration system, a placeholder date was entered in the "Date of IRB Approval" field.
Management information
Registered date
| 2023 | Year | 01 | Month | 04 | Day |
Last modified on
| 2025 | Year | 01 | Month | 05 | Day |
Link to view the page
Value
https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000056899
