UMIN-CTR Clinical Trial
| Unique ID issued by UMIN | UMIN000049254 |
|---|---|
| Receipt number | R000056095 |
| Scientific Title | Evaluation of the potential impact of insect-specific virus infections in mosquito blood-feeding behavior |
| Date of disclosure of the study information | 2022/10/18 |
| Last modified on | 2024/04/19 10:45:07 |
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Basic information
Public title
Evaluation of the potential impact of insect-specific virus infections in mosquito blood-feeding behavior
Acronym
Potential impact of insect-specific virus on mosquito feeding behavior
Scientific Title
Evaluation of the potential impact of insect-specific virus infections in mosquito blood-feeding behavior
Scientific Title:Acronym
Potential impact of insect-specific virus on mosquito feeding behavior
Region
| Japan |
Condition
Condition
N/A
Classification by specialty
| Adult |
Classification by malignancy
Others
Genomic information
NO
Objectives
Narrative objectives1
Investigate the potential impact of insect-specific virus infection on mosquito's human host-seeking ability
Basic objectives2
Others
Basic objectives -Others
Impact of insect-specific virus infection on mosquito's human host-seeking ability
Trial characteristics_1
Trial characteristics_2
Developmental phase
Assessment
Primary outcomes
Attraction of mosquitoes to human arms
Key secondary outcomes
Base
Study type
Interventional
Study design
Basic design
Single arm
Randomization
Non-randomized
Randomization unit
Blinding
Open -no one is blinded
Control
Self control
Stratification
Dynamic allocation
Institution consideration
Blocking
Concealment
Intervention
No. of arms
1
Purpose of intervention
Educational,Counseling,Training
Type of intervention
| Other |
Interventions/Control_1
Meshed cages that contain insect-specific virus-infected mosquitoes or uninfected ones will be set 2 cm away from the volunteer's arms. The mosquito attraction will be examined for 5min. This assay will be repeated three times.
Interventions/Control_2
Interventions/Control_3
Interventions/Control_4
Interventions/Control_5
Interventions/Control_6
Interventions/Control_7
Interventions/Control_8
Interventions/Control_9
Interventions/Control_10
Eligibility
Age-lower limit
| 18 | years-old | <= |
Age-upper limit
| 65 | years-old | > |
Gender
Male and Female
Key inclusion criteria
-Healthy male/female (age from 18 to 64 years old) who can understand the informed consent to participate in this study
-Person who does not have any disabilities and/or severe injury
Key exclusion criteria
-Person who has any diseases, and/or disabilities/severe injury on the arms
-Person who is younger than 18 or older than 65 years old
-Person who has experienced a strong allergic response to mosquito bites and/or medicine for insect bites
-Person who cannot understand the informed consent of this study
-Person who cannot refrain the use of any perfume/sunscreen, which may affect mosquito behavior on the day of study
Target sample size
15
Research contact person
Name of lead principal investigator
| 1st name | Kozo |
| Middle name | |
| Last name | Watanabe |
Organization
Ehime University
Division name
Center for Marine Environmental Studies
Zip code
790-8577
Address
Bunkyo-cho 3, Matsuyama, Ehime
TEL
0899279855
watanabe.kozo.mj@ehime-u.ac.jp
Public contact
Name of contact person
| 1st name | Yasutsugu |
| Middle name | |
| Last name | Suzuki |
Organization
Ehime University
Division name
Center for Marine Environmental Studies
Zip code
790-8577
Address
Bunkyo-cho 3, Matsuyama, Ehime
TEL
0899279855
Homepage URL
suzuki.yasutsugu.ao@ehime-u.ac.jp
Sponsor or person
Institute
Ehime University
Institute
Department
Personal name
Funding Source
Organization
Ministry of Education, Culture, Sports, Science and Technology-Japan
Organization
Division
Category of Funding Organization
Japanese Governmental office
Nationality of Funding Organization
Other related organizations
Co-sponsor
Name of secondary funder(s)
IRB Contact (For public release)
Organization
Institutional Review Board,Ehime University Hospital
Address
454 Shitsukawa, Toon, Ehime
Tel
089-960-5172
rinri@m.ehime-u.ac.jp
Secondary IDs
Secondary IDs
NO
Study ID_1
Org. issuing International ID_1
Study ID_2
Org. issuing International ID_2
IND to MHLW
Institutions
Institutions
Other administrative information
Date of disclosure of the study information
| 2022 | Year | 10 | Month | 18 | Day |
Related information
URL releasing protocol
https://royalsocietypublishing.org/doi/10.1098/rsos.231373?url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acr
Publication of results
Published
Result
URL related to results and publications
https://royalsocietypublishing.org/doi/10.1098/rsos.231373?url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acr
Number of participants that the trial has enrolled
6
Results
The host-seeking ability of Aedes aegypti mosquitoes were not significantly changed by insect-specific virus infections.
Results date posted
| 2024 | Year | 04 | Month | 19 | Day |
Results Delayed
Results Delay Reason
Date of the first journal publication of results
Baseline Characteristics
Females and males, age range: 20 to 50, As per the key inclusion criteria
Participant flow
6 Volunteers who those met the requirement with agreement. Th volunteers' arms were placed underneath the cages containing insect-specific virus (no infectious to humans)- or mock-injected mosquitoes with 2 cm-distance. The assay was performed three times for each volunteer. The mosquito behaviour was recorded by a video camera from above the cage for 5 min.
Adverse events
No
Outcome measures
Mosquito's human arm seeking ability
Plan to share IPD
IPD sharing Plan description
Progress
Recruitment status
Completed
Date of protocol fixation
| 2022 | Year | 10 | Month | 01 | Day |
Date of IRB
| 2022 | Year | 09 | Month | 26 | Day |
Anticipated trial start date
| 2022 | Year | 10 | Month | 01 | Day |
Last follow-up date
| 2023 | Year | 03 | Month | 31 | Day |
Date of closure to data entry
Date trial data considered complete
Date analysis concluded
Other
Other related information
Management information
Registered date
| 2022 | Year | 10 | Month | 18 | Day |
Last modified on
| 2024 | Year | 04 | Month | 19 | Day |
Link to view the page
Value
https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000056095
