Unique ID issued by UMIN | UMIN000049785 |
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Receipt number | R000055661 |
Scientific Title | Living donor liver transplantation for non-resectable colorectal liver metastases |
Date of disclosure of the study information | 2023/04/01 |
Last modified on | 2023/12/14 10:39:08 |
Living donor liver transplantation for non-resectable colorectal liver metastases
Living donor liver transplantation for non-resectable colorectal liver metastases
Living donor liver transplantation for non-resectable colorectal liver metastases
Living donor liver transplantation for non-resectable colorectal liver metastases
Japan |
non-resectable colorectal liver metastases
Hepato-biliary-pancreatic surgery |
Malignancy
YES
Efficacy and safety of living donor liver transplantation for non-resectable colorectal liver metastases
Safety,Efficacy
3 year Overall survival
Interventional
Single arm
Non-randomized
Open -no one is blinded
Uncontrolled
1
Treatment
Maneuver |
living donor liver transplantation
18 | years-old | <= |
70 | years-old | > |
Male and Female
1. histological evidence of colorectal adenocarcinoma
2. Genetic testing for cancer (RAS, BRAFV600E, MSI, mismatch repair genes, etc.) must have been performed.
3. The primary colorectal cancer has been curatively resected.
4. the metastatic disease must be considered as surgically unresectable. Liver metastases are not limited to first occurrence, but include those after hepatectomy.
5. The metastases must be located in liver only by imaging diagnosis.
6. No history of distant metastasis other than liver metastasis. Exceptions: Patients with no more than 3 lung metastases and no recurrence for more than 6 months after treatment of lung metastases are eligible.
7.Patients must have received chemotherapy for unresectable liver metastases. The duration of chemotherapy should be at least 3 months, and the regimen should be within the standard of care according to the colorectal cancer guidelines.
8. Patients must be at least 18 years old.
1. patients who have undergone chemotherapy and are judged to have progressed (PD).
2. an infectious disease requiring treatment
3. pregnant or possibly pregnant.
4. Patients with psychiatric disorders or psychiatric symptoms that interfere with daily life and make it difficult for them to participate in the study.
5. Other cases that are considered not appropriate for usual living donor liver transplantation
23
1st name | Etsuro |
Middle name | |
Last name | Hatano |
Kyoto University
Division of Hepato-Biliary-Pancreatic Surgery and Transplantation, Department of Surgery
606-8507
54 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto city
075-751-3242
etsu@kuhp.kyoto-u.ac.jp
1st name | Ken |
Middle name | |
Last name | Fukumitsu |
Kyoto University
Division of Hepato-Biliary-Pancreatic Surgery and Transplantation, Department of Surgery
606-8507
54 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto city
075-751-3242
tsurugi@kuhp.kyoto-u.ac.jp
Kyoto University
none
Other
Kyoto University Graduate School and Faculty of Medicine, Ethics Committee
Konoe-cho, Yoshida, Sakyo-ku, Kyoto-city
075-753-4680
ethcom@kuhp.kyoto-u.ac.jp
NO
2023 | Year | 04 | Month | 01 | Day |
Unpublished
Open public recruiting
2022 | Year | 12 | Month | 14 | Day |
2022 | Year | 12 | Month | 12 | Day |
2023 | Year | 09 | Month | 25 | Day |
2032 | Year | 09 | Month | 24 | Day |
2022 | Year | 12 | Month | 14 | Day |
2023 | Year | 12 | Month | 14 | Day |
Value
https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000055661
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