Unique ID issued by UMIN | UMIN000046574 |
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Receipt number | R000053121 |
Scientific Title | Effect of Sacubitril/Valsartan on Natriuretic Peptide in Patients with Compensated Heart Failure |
Date of disclosure of the study information | 2022/01/08 |
Last modified on | 2022/07/09 11:50:41 |
Effect of Sacubitril/Valsartan on Natriuretic Peptide in Patients with Compensated Heart Failure
Sacubitril/Valsartan in Compensated HF
Effect of Sacubitril/Valsartan on Natriuretic Peptide in Patients with Compensated Heart Failure
Sacubitril/Valsartan in Compensated HF
Japan |
chronic heart failure
Cardiology |
Others
NO
To investigate the efficacy and prognostic impact of ARNI in the compensated HF.
Safety,Efficacy
natriuretic peptide families
1) Serum Renin, aldosterone and AngiotensinII
2) medication
3) age, gender, presence of de novo or recurrent HF, etiology of HF, past medical history (risk factors for atherosclerosis [diabetes mellitus, hypertension, and dyslipidemia], and chronic kidney disease), vital signs (systolic blood pressure [SBP] and heart rate), laboratory data (blood urea nitrogen, creatinine, total bilirubin, sodium, potassium, hemoglobin and C-reactive protein [CRP])
4) left ventricular ejection fraction (LVEF) on echocardiography
5) Prognosis (mortality and heart failure event within 1 year)
Interventional
Parallel
Randomized
Individual
Open -no one is blinded
Active
2
Treatment
Medicine |
Treatment of Sacubitril/Valsartan
Treatment of ACE-I
20 | years-old | <= |
100 | years-old | > |
Male and Female
Compensated HF patients visiting the outpatient clinics who were administrated angiotensin converting enzyme inhibitor (ACE-I) or angiotensin receptor blocker (ARB)
Patients with end-stage chronic kidney disease (eGFR<30 mL/min/1.73m2) were excluded from present study
80
1st name | Akihiro |
Middle name | |
Last name | Shirakabe |
Nippon Medical School Chiba Hokusoh Hospital
Division of Intensive Care Unit
2701694
1715 Kamagari, Inzai, Chiba 270-1694, Japan
0476991111
s6042@nms.ac.jp
1st name | Akihiro |
Middle name | |
Last name | Shirakabe |
Nippon Medical School Chiba Hokusoh Hospital
Division of Intensive Care Unit
2701694
1715 Kamagari, Inzai, Chiba 270-1694, Japan
0476991111
s6042@nms.ac.jp
Nippon Medical School
None
Other
Hasegawa Hospital
85
043-444-0137
bwa41248@nifty.com
NO
2022 | Year | 01 | Month | 08 | Day |
Unpublished
Open public recruiting
2021 | Year | 01 | Month | 19 | Day |
2021 | Year | 01 | Month | 19 | Day |
2021 | Year | 01 | Month | 20 | Day |
2023 | Year | 12 | Month | 31 | Day |
2022 | Year | 01 | Month | 07 | Day |
2022 | Year | 07 | Month | 09 | Day |
Value
https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000053121
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