Unique ID issued by UMIN | UMIN000044655 |
---|---|
Receipt number | R000050723 |
Scientific Title | Examination of the relationship between biomarkers in nasal discharge during initial wheezing and the onset of asthma in early childhood |
Date of disclosure of the study information | 2021/06/26 |
Last modified on | 2021/06/25 13:36:08 |
Examination of the relationship between biomarkers in nasal discharge during initial wheezing and the onset of asthma in early childhood
Examination of the relationship between biomarkers in nasal discharge during initial wheezing and the onset of asthma in early childhood
Examination of the relationship between biomarkers in nasal discharge during initial wheezing and the onset of asthma in early childhood
Examination of the relationship between biomarkers in nasal discharge during initial wheezing and the onset of asthma in early childhood
Japan |
Bronchial asthma
Pneumology | Clinical immunology | Pediatrics |
Others
NO
The purpose of this study is to clarify biomarkers that predict the onset of recurrent wheezing and asthma using blood and nasal discharge obtained under normal medical care for children who first wheeze in infancy.
Efficacy
Exploratory
Pragmatic
Not applicable
Differences in nasal discharge biomarkers tested at the time of screening between children in the IgE-related asthma group, non-IgE-related asthma group, and non-asthma group.
Observational
Not applicable |
2 | years-old | > |
Male and Female
Infants under 2 years old who were hospitalized for lower respiratory tract infection and wheezing for the first time after birth
Children who have consented to participate in this study from their substitutes
Preterm infants (less than 37 weeks)
Children who required respiratory management during the newborn period, children with chronic lung disease
Children with a history of autoimmune diseases or metabolic diseases
Children who received treatment by steroids (inhalation, nasal drops, systemic administration) before sample collection (within 24 hours)
Other children who the researcher deems inappropriate for participating in this study
148
1st name | Fumitaka |
Middle name | |
Last name | Takayanagi |
Dokkyo Medical University Hospital
Pediatrics
321-0293
880 Ozikiitakobayasshi Mibu Shimotsuga Tochigi
0282-86-1111
fumi_fena@yahoo.co.jp
1st name | Fumitaka |
Middle name | |
Last name | Takayanagi |
Dokkyo Medical University Hospital
Pediatrics
321-0293
880 Ozikiitakobayasshi Mibu Shimotsuga Tochigi
0282-86-1111
fumi_fena@yahoo.co.jp
Dokkyo Medical University Hospital
Dokkyo Medical University Hospital
Self funding
Dokkyo Medical University Hospital
880 Ozikiitakobayasshi Mibu Shimotsuga Tochigi
0282-86-1111
fumi_fena@yahoo.co.jp
NO
2021 | Year | 06 | Month | 26 | Day |
Unpublished
Open public recruiting
2021 | Year | 06 | Month | 01 | Day |
2021 | Year | 06 | Month | 01 | Day |
2021 | Year | 06 | Month | 01 | Day |
2029 | Year | 03 | Month | 31 | Day |
This study is a multicenter prospective cohort study.
We enroll all patients who visited our hospital between approval by the Clinical Research Ethics Committee in 2021 and March 2023 who met the selection criteria.
We take a nasal discharge sample at admission and measure biomarkers.
After that, a questionnaire survey will be conducted every year for 5 years to evaluate the onset of asthma.
In addition, after 2 years and 5 years, asthma phenotypes will be classified according to the presence or absence of an increase in IgE, and it will be examined whether biomarkers differ for each phenotype.
2021 | Year | 06 | Month | 25 | Day |
2021 | Year | 06 | Month | 25 | Day |
Value
https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000050723