Unique ID issued by UMIN | UMIN000043187 |
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Receipt number | R000049290 |
Scientific Title | The study of efficacy of atezolizumab plus bevacizumab in patients with hepatocellular carcinoma(HCC): Multicenter analysis. |
Date of disclosure of the study information | 2021/01/30 |
Last modified on | 2021/01/30 16:05:44 |
The study of efficacy of atezolizumab plus bevacizumab in patients with hepatocellular carcinoma(HCC): Multicenter analysis.
The study of efficacy of atezolizumab plus bevacizumab in patients with hepatocellular carcinoma(HCC): Multicenter analysis.
The study of efficacy of atezolizumab plus bevacizumab in patients with hepatocellular carcinoma(HCC): Multicenter analysis.
The study of efficacy of atezolizumab plus bevacizumab in patients with hepatocellular carcinoma(HCC): Multicenter analysis.
Japan |
Hepatocellular carcinoma
Hepato-biliary-pancreatic medicine |
Malignancy
NO
The objective of this study is to investigate the prognostic and predictive factors of atezolizumab plus bevacizumab in patients with HCC.
Safety,Efficacy
OS
PFS
OR/DCR
Safety
Observational
20 | years-old | <= |
90 | years-old | >= |
Male and Female
1)At least 20 years old when consent is given
2)Histologically or clinically (imaging and tumor markers) diagnosed hepatocellular carcinoma found to be ineligible for resection or local treatment
3)Lesions measurable with contrast-enhanced CT or contrast-enhanced MRI
4)Child-Pugh class A or B
5)ECOG performance status (PS) of 0 or 1
6) Adequate functional reserve of major organs
7)Capable of complying with requirements about visit days, medication, and laboratory tests
8)The patient has been fully informed and has an adequate understanding about the study and has given voluntary written consent before participation
1)Clinically significant ascites (refractory ascites requiring drainage)
2)Esophageal varices with the potential to bleed
3)Any of the following 6 or fewer months before enrollment in this research:
Myocardial infarction, unstable angina, cardiac failure, cerebrovascular disorder
4)Brain tumor
5)On dialysis
6)Gastrointestinal hemorrhage during past 3 months
7)Active multiple cancer
8)Any of the following concurrent diseases:
Grade 3 or greater arrhythmia or poorly controlled hypertension according to the JCOG/JSCO Japanese translation of the NCI Common Terminology Criteria for Adverse Events v 4.0 (CTCAE v 4.0)
9)Orally taking an herbal medicine approved for the treatment of cancer (e.g., shosaikoto)
10)Human immunodeficiency virus (HIV) or acquired immune deficiency syndrome (AIDS) related disease
11) Pregnant or nursing
12) Otherwise found ineligible as a subject by the researcher
360
1st name | Makoto |
Middle name | Chuma |
Last name | Chuma |
Yokohama City University Medical Center
Gastroenterological Center
232-0024
Yokohama
045-261-5656
chuma@yokohama-cu.ac.jp
1st name | Makoto |
Middle name | |
Last name | Chuma |
Yokohama City University Medical Center
Gastroenterological Center
232-0024
Yokohama
045-261-5656
chuma@yokohama-cu.ac.jp
Yokohama City University Medical Center
Yokohama City University Medical Center
Self funding
Department of Gastroenterology, Internal Medicine, Kitasato University School of Medicine,Sagamihara, Japan
Division of Gastroenterology and Hepatology, Department of Interna Medicine, Tokai
University School of Medicine, Isehara, Japan
Hepatobiliary and Pancreatic Medical Oncology, Kanagawa Cancer Center Hospital,
Yokohama, Japan
Division of Gastroenterology and Hepatology, Department of Interna Medicine, St. Marianna
University School of Medicine, Kawasaki, Japan
Division of Gastroenterology and Hepatology, Tokai University Oiso Hospital, Kanagawa, Japan.
Department of Gastroenterology, Shonan Kamakura General Hospital, Kamakura, Japan.
Department of Gastroenterology, Shonan Fujisawa General Hospital, Fujisawa, Japan.
Gastroenterology Division, Hadano Red Cross Hospital, Hadano, Japan
Division of Gastroenterology, Saiseikai Yokohamashi-Nanbu Hospital, Yokohama, Japan
Department of Gastroenterology, Yokohama Minami Kyosai Hospital, Yokohama, Japan
Department of Gastroenterology, Fujisawa City Hospital, Fujisawa, Kanagawa, Japan
Department of Gastroenterology, Kanagawa Prefectural Ashigarakami Hospital, Kanagawa, Japan.
Department of Gastroenterology, Internal Medicine, Kitasato University School of Medicine,Sagamihara, Japan
Division of Gastroenterology and Hepatology, Department of Interna Medicine, Tokai
University School of Medicine, Isehara, Japan
Hepatobiliary and Pancreatic Medical Oncology, Kanagawa Cancer Center Hospital,
Yokohama, Japan
Division of Gastroenterology and Hepatology, Department of Interna Medicine, St. Marianna
University School of Medicine, Kawasaki, Japan
Division of Gastroenterology and Hepatology, Tokai University Oiso Hospital, Kanagawa, Japan.
Department of Gastroenterology, Shonan Kamakura General Hospital, Kamakura, Japan.
Department of Gastroenterology, Shonan Fujisawa General Hospital, Fujisawa, Japan.
Gastroenterology Division, Hadano Red Cross Hospital, Hadano, Japan
Division of Gastroenterology, Saiseikai Yokohamashi-Nanbu Hospital, Yokohama, Japan
Department of Gastroenterology, Yokohama Minami Kyosai Hospital, Yokohama, Japan
Department of Gastroenterology, Fujisawa City Hospital, Fujisawa, Kanagawa, Japan
Department of Gastroenterology, Kanagawa Prefectural Ashigarakami Hospital, Kanagawa, Japan.
Department of Gastroenterology, Yamato City Hospital, Yamato, Kanagawa, Japan
Department of Gastroenterology, Yokosuka City Hospital, Yokosuka, Kanagawa, Japan
Department of Gastroenterology, Yokohama City University Hospital, Yokohama, Japan
Yokohama City University Medical Center
Gastroenterological Center, Yokohama City University Medical Center 4-57 Urafune-cho, Minami-ku, Yokohama, Kanagawa 232-0024, Japan
0452615656
m_abe@yokohama-cu.ac.jp
NO
2021 | Year | 01 | Month | 30 | Day |
Unpublished
Open public recruiting
2020 | Year | 09 | Month | 01 | Day |
2021 | Year | 01 | Month | 04 | Day |
2021 | Year | 01 | Month | 04 | Day |
2027 | Year | 08 | Month | 31 | Day |
The objective of this study is to investigate the prognostic and predictive factors of atezolizumab plus bevacizumab in patients with HCC.
2021 | Year | 01 | Month | 30 | Day |
2021 | Year | 01 | Month | 30 | Day |
Value
https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000049290
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