Unique ID issued by UMIN | UMIN000043910 |
---|---|
Receipt number | R000049020 |
Scientific Title | Association between brain atrophy and intestinal permeability in patients with multiple sclerosis |
Date of disclosure of the study information | 2021/06/01 |
Last modified on | 2024/04/15 12:28:45 |
Association between brain atrophy and intestinal permeability in patients with multiple sclerosis
Brain atrophy and intestinal permeability in MS
Association between brain atrophy and intestinal permeability in patients with multiple sclerosis
Brain atrophy and intestinal permeability in MS
Japan |
multiple sclerosis
Neurology |
Others
NO
To determine the association between the rate of brain atrophy and intestinal permeability in patients with MS
Others
association
Correlation between the rate of brain atrophy over 48 months and intestinal permeability measured at baseline.
Association between intestinal permeability at baseline and disease subtypes, disability, cognition, brain volume and disease modifying therapy
Interventional
Single arm
Non-randomized
Open -no one is blinded
Uncontrolled
1
Diagnosis
Medicine |
A standard solution of lactulose (5 g) and mannitol (2 g)in 500 mL of tap water was ingested before bed. Urine was collected the following morning in a container (with 5 mL of thymol solution).
18 | years-old | <= |
80 | years-old | > |
Male and Female
MS and related disorders (neuromyelitis optica spectrum disorders (NMOSD) and clinically isolated sydrome) will be included. MS is diagnosed by McDonald's criteria 2017 and NMOSD is diagnosed by Wingerchuk's criteria 2015.
Persons who have
1. pace makers or magnetic metals
2. claustrophobia
3. unstable general condition and vital signs
4. difficulty in informed consent
5. cancers or inflammatory bowel disease
6. diabetes mellitus
, pregnant women and persons who is not suitable for the participants according to the doctor's decision.
40
1st name | Yoichiro |
Middle name | |
Last name | Nishida |
Tokyo Medical and Dental University
Department of Neurology
1648607
1-5-45, Yushima, Bunkyo-ku, Tokyo
0358035234
yktenuro@gmail.com
1st name | Hiroaki |
Middle name | |
Last name | Yokote |
Nitobe Memorial Nakano General Hospital
Department of Neurology
1648607
4-59-16, Chuo, Nakano-ku, Tokyo
0333821231
yktenuro@gmail.com
Department of Neurology and Neurological Science, Tokyo Medical and Dental University
The Japanese society for neuroimmunology
Other
Tokyo Medical and Dental Univeristy
1-5-45, Yushima, Bunkyo-ku, Tokyo
0333821231
yktenuro@gmail.com
NO
2021 | Year | 06 | Month | 01 | Day |
Unpublished
Terminated
2021 | Year | 04 | Month | 13 | Day |
2021 | Year | 04 | Month | 13 | Day |
2021 | Year | 06 | Month | 01 | Day |
2026 | Year | 03 | Month | 31 | Day |
2021 | Year | 04 | Month | 13 | Day |
2024 | Year | 04 | Month | 15 | Day |
Value
https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000049020