Unique ID issued by UMIN | UMIN000042727 |
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Receipt number | R000048774 |
Scientific Title | Searching for Personalized Disease Mechanisms for Primary Sclerosing Cholangitis Using Human Bile-Derived Bile Organoids |
Date of disclosure of the study information | 2021/04/01 |
Last modified on | 2020/12/11 17:37:41 |
Study of primary sclerosing cholangitis using bile-derived organoids
Bile Duct Organoid Research in Primary Sclerosing Cholangitis
Searching for Personalized Disease Mechanisms for Primary Sclerosing Cholangitis Using Human Bile-Derived Bile Organoids
Study on the disease mechanism of organoid-induced primary sclerosing cholangitis
Japan |
Primary Sclerosing Cholangitis
Hepato-biliary-pancreatic medicine |
Others
NO
Identifying new disease mechanisms in PSC using patient-derived bile-derived bile duct organoids.
Others
In order to find out the characteristic features of bile duct organoids in PSC, we will prepare bile-derived bile duct organoids in two groups of patients undergoing ERCP at our hospital, PSC patients and non-PSC patients, and analyze their morphological changes and inflammatory profiles in detail in vitro.
Identification of a new disease-specific mechanism using bile-derived bile duct organoids generated from PSC patients.
Changes in the morphology and inflammatory profile of bile-derived bile duct organoids among PSC patients or various diseases
Interventional
Parallel
Non-randomized
Open -no one is blinded
Placebo
2
Diagnosis
Maneuver |
Collect bile during ERCP for PSC patients
Collect bile during ERCP for non-PSC patients
Not applicable |
Not applicable |
Male and Female
Patients undergoing ERCP for liver, bile duct, or pancreas disease at our hospital who understand the contents of this study and have given written consent to participate in the study.
Patients who have requested to be excluded from the study
The principal investigator or sub-investigator determines that the patient is ineligible to participate in the research
30
1st name | hiroki |
Middle name | |
Last name | kawashima |
Nagoya University Hospital
Department of Endoscopy
466-8560
65, Tsuruma-cho, Showa-ku, Nagoya
0527412111
h-kawa@med.nagoya-u.ac.jp
1st name | Norihiro |
Middle name | |
Last name | Imai |
Nagoya University Hospital
Department of Endoscopy
466-8560
65, Tsuruma-cho, Showa-ku, Nagoya
0527412111
norihiro@med.nagoya-u.ac.jp
Nagoya University
Nagoya University
Self funding
Ethics Committee
65, Tsuruma-cho, Showa-ku, Nagoya
0527412111
ethics@med.nagoya-u.ac.jp
NO
2021 | Year | 04 | Month | 01 | Day |
Unpublished
Preinitiation
2020 | Year | 12 | Month | 11 | Day |
2021 | Year | 04 | Month | 01 | Day |
2024 | Year | 09 | Month | 30 | Day |
2020 | Year | 12 | Month | 11 | Day |
2020 | Year | 12 | Month | 11 | Day |
Value
https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000048774
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