Unique ID issued by UMIN | UMIN000043171 |
---|---|
Receipt number | R000048691 |
Scientific Title | Changes in the number of Streptococcus mutans after intake of Lactobacillus rhamnosus L8020-containing tablets |
Date of disclosure of the study information | 2021/01/29 |
Last modified on | 2022/03/25 14:13:11 |
Changes in the number of Streptococcus mutans after intake of Lactobacillus rhamnosus L8020-containing tablets
Changes in the number of Streptococcus mutans after intake of L8020-containing tablets
Changes in the number of Streptococcus mutans after intake of Lactobacillus rhamnosus L8020-containing tablets
Changes in the number of Streptococcus mutans after intake of L8020-containing tablets
Japan |
Healthy adults
Dental medicine | Adult |
Others
NO
To investigate changes in the number of Streptococcus mutans after the intake of tablets containing L8020
Others
To investigate changes in the number of Streptococcus mutans due to differences in the expression of cnm gene
Changes in the distribution of semi-quantitative values of the number of Streptococcus mutans 4 weeks after intake
Interventional
Single arm
Non-randomized
Open -no one is blinded
Self control
1
Prevention
Food |
Volunteers ingest one L8020-containing tablet every day after dinner for 4 weeks.
20 | years-old | <= |
40 | years-old | >= |
Male and Female
1. Healthy adult without dental caries, gingivitis and periodontal disease
2. Subject who will be able to prohibit other L8020 products during experiment period
3. Subject who provides written informed consents
1. Subject with allergy to dairy products
2. Subject with a history of antibiotic treatment within a month before experiment
3. Subject who may receive oral treatment of topical fluoride during experiment period
4. Subjects who may be newly treated with povidone-iodine during experiment period
100
1st name | Hiroki |
Middle name | |
Last name | Nikawa |
Graduate School of Biomedical and Health Sciences, Hiroshima University
Department of Oral Biology & Engineering
734-8551
1-2-3 Kasumi, Minami-ku, Hiroshima
082-257-5797
hirocky@hiroshima-u.ac.jp
1st name | Masae |
Middle name | |
Last name | Kitagawa |
Hiroshima University Hospital
Center of Oral Clinical Examination
731-8553
1-2-3 Kasumi, Minami-ku, Hiroshima
082-257-5727
mhiraoka@hiroshima-u.ac.jp
Department of Oral Biology & Engineering, Graduate School of Biomedical and Health Sciences, Hiroshima University
Self funding
Self funding
Ethical Committee for Clinical Research of Hiroshima University
Kasumi 1-2-3 Minami-ku, Hiroshima
082-257-1551
iryo-seisaku@office.hiroshima-u.ac.jp
NO
2021 | Year | 01 | Month | 29 | Day |
Unpublished
81
Completed
2021 | Year | 01 | Month | 20 | Day |
2021 | Year | 01 | Month | 27 | Day |
2021 | Year | 01 | Month | 27 | Day |
2022 | Year | 03 | Month | 31 | Day |
2021 | Year | 01 | Month | 29 | Day |
2022 | Year | 03 | Month | 25 | Day |
Value
https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000048691
Research Plan | |
---|---|
Registered date | File name |
Research case data specifications | |
---|---|
Registered date | File name |
Research case data | |
---|---|
Registered date | File name |