Unique ID issued by UMIN | UMIN000042412 |
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Receipt number | R000048376 |
Scientific Title | The metabolic implication of the breast reduction |
Date of disclosure of the study information | 2020/11/11 |
Last modified on | 2020/11/11 07:06:09 |
The Metabolic implication of the breast reduction
MIOBR
The metabolic implication of the breast reduction
MIOBR
Asia(except Japan) |
The augmented risk biomarkers of obesity-related diseases decrease after weight loss with diet or surgical removal of adipose tissue in patients with increased fat storage. Since the breast consists of mainly fat tissue, breast reduction surgery can lessen these augmented levels.
Endocrinology and Metabolism | Breast surgery | Plastic surgery |
Others
NO
to evaluate the impact of breast reduction surgery on risk markers of obesity-related diseases.
Efficacy
Exploratory
Explanatory
Not applicable
Preoperative and six months after surgery the levels of fasting blood glucose, insulin, hemoglobinA1c, triglyceride, total cholesterol, low-density lipoprotein, high-density lipoprotein, small dense low-density lipoprotein, macrophage chemotactic protein-1, adiponectin, lipoprotein-associated phospholipase A2, pentraxin-3, chemerin, interferon-gamma, interleukin-6, tumor necrosis factor-alfa, and highly sensitive C reactive protein were compared using Wilcoxon sign test.
Spearman correlation was used to investigate any relationship between the magnitudes of changes of the laboratory values and body mass index scores, and the amount of removed breast tissue.
Interventional
Single arm
Non-randomized
Open -no one is blinded
Uncontrolled
NO
NO
1
Treatment
Other |
Breast reduction surgery
Control was 6 months later
18 | years-old | < |
65 | years-old | > |
Female
Women who requested breast reduction surgery.
Each patient had breast hypertrophy with a distance between suprasternal notch and nipple greater than 28cm
Exclusion criteria were cardiovascular diseases, metabolic diseases such as diabetes and Cushing disease, connective tissue diseases, liver diseases, and endocrine disorders.
35
1st name | Yavuz |
Middle name | |
Last name | Kececi |
Celal Bayar University
Plastic and Reconstructive Surgery
45100
Celal Bayar University, Hafsa Sultan Hastanesi, Yunusmere, Manisa, Turkey
905323825901
yavuz.kececi@gmail.com
1st name | Yavuz |
Middle name | |
Last name | Kececi |
Celal Bayar University
Plastic and Reconstructive Surgery
45100
Celal Bayar University, Hafsa Sultan Hastanesi, Yunusmere, Manisa, Turkey
905323825901
yavuz.kececi@gmail.com
Celal Bayar University, School of Medicine
THE SCIENTIFIC AND TECHNOLOGICAL RESEARCH COUNCIL OF TURKEY
Government offices of other countries
Turkey
None
Celal Bayar University, School of Medicine
Celal Bayar University, School of Medicine, Yunusemre, 45100, Manisa
902362331920
etikkurul@cbu.edu.tr
NO
2020 | Year | 11 | Month | 11 | Day |
https://data.mendeley.com/datasets/r4vr38m59n/1
Unpublished
https://data.mendeley.com/datasets/r4vr38m59n/1
24
Thirty-five patients were enrolled in the study. Twenty-four patients came to a six-month evaluation, so the study was conducted on these 24 patients' data. The mean age of the patients was 46.7 years. The mean weight of the breast tissue removed during surgery was 1705 grams.
2020 | Year | 11 | Month | 11 | Day |
The patients who underwent reduction mammoplasty operations between March 2018 and February 2019 were enrolled in the study. Each patient had breast hypertrophy with a distance between suprasternal notch and nipple greater than 28cm. Exclusion criteria were cardiovascular diseases, metabolic diseases such as diabetes and Cushing disease, connective tissue diseases, liver diseases, and endocrine disorders. The study was performed according to the Declaration of Helsinki. Informed written consent was obtained from each subject, and the Institutional Ethics Committee approved this study (28.06.2017- 2O.478.486). The superomedial pedicle technique was performed on all patients.
Participants were enrolled before and 6 months after the surgery.
None
Fasting plasma glucose, triglyceride, total cholesterol, low-density lipoprotein, high-density lipoprotein, and high sensitive C-reactive protein (hsCRP) levels were measured by using the immunoturbidimetric method at Beckman Coulter AU5800 auto-analyzer; serum insulin levels by using chemiluminescence enzyme immunometric method at UniCel 800 Immunoassay System - Beckman Coulter; A1C analysis by using ion changing method at Tosoh G7 HPLC Analyzer.
The serum levels of small dense low-density lipoprotein, Elabscience, Houston, Texas, USA, Monocyte chemoattractant protein-1, IL-6, TNF-alfa, and lipoprotein-associated phospholipase A2, pentraxin-3, interferon-gamma, chemerin, and adiponectin were measured by using commercially available ELISA kits. Anthropometric measurements and laboratory tests were performed preoperatively and six months postoperatively.
https://data.mendeley.com/datasets/r4vr38m59n/1
mendeley repository
Completed
2017 | Year | 06 | Month | 28 | Day |
2017 | Year | 06 | Month | 28 | Day |
2018 | Year | 03 | Month | 14 | Day |
2019 | Year | 02 | Month | 05 | Day |
2020 | Year | 11 | Month | 11 | Day |
2020 | Year | 11 | Month | 11 | Day |
Value
https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000048376
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