Unique ID issued by UMIN | UMIN000042061 |
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Receipt number | R000047878 |
Scientific Title | "Study of resistance to COVID-19 of medical staff" -(Pilot Study)- |
Date of disclosure of the study information | 2020/10/09 |
Last modified on | 2023/04/11 10:26:39 |
"Study of resistance to COVID-19 of medical staff" -(Pilot Study)-
"Study of resistance to COVID-19 of medical staff" -(Pilot Study)-
"Study of resistance to COVID-19 of medical staff" -(Pilot Study)-
"Study of resistance to COVID-19 of medical staff" -(Pilot Study)-
Japan |
COVID-19
Medicine in general | Infectious disease |
Others
YES
To clarify the internal characteristics of healthcare workers who did not become infected with this disease even through close contact, in contrast to those infected.
Others
Elucidate the factors of mental stress of medical staff who treat COVID-19, and develop and develop stress reduction methods
IFNlamda4 gene polymorphism
Observational
20 | years-old | <= |
Not applicable |
Male and Female
(1) Persons infected with the new coronavirus (infected persons) and persons who did not become infected despite having similar contact with infected persons (non-infected close contacts)
(2) Gender: No matter
(3) Target age: 20 years old and over
(4) Subjects who have obtained their consent to participate in this test
(1) Those who are positive for PCR test at the time of obtaining consent
(2) Persons who have symptoms of suspected infection such as COVID-19 at the time of obtaining consent
(3) Others who are judged by the doctor in charge to be inappropriate for this study
165
1st name | Kunihiro |
Middle name | |
Last name | Yamagata |
University of Tsukuba
Department of nephrology, faculty of medicine
3058575
1-1-1, Tennnodai, Tsukuba, Ibaraki
0298533202
k-yamaga@md.tsukuba.ac.jp
1st name | Hirayasu |
Middle name | |
Last name | Kai |
University of Tsukuba
Department of nephrology, faculty of medicine
3058575
1-1-1, Tennnodai, Tsukuba, Ibaraki
0298533202
hirayasu.kai@md.tsukuba.ac.jp
other
Ministry of Health, Labour and Welfare
Japanese Governmental office
Department of nephrology, faculty of medicine
1-1-1, Tennnodai, Tsukuba, Ibaraki
0298533022
sien.ningenss@un.tsukuba.ac.jp
NO
2020 | Year | 10 | Month | 09 | Day |
https://nephtsukuba.wixsite.com/nephrology-tsukuba/blank
Partially published
https://www.frontiersin.org/articles/10.3389/fmicb.2022.943877/full
166
We found that rs12329760 in the TMPRSS2 gene, a missense variant common in East Asian populations, contributes to protection against SARS-CoV-2 infection. TMPRSS2 is a protease responsible for SARS-CoV-2 entry and syncytium formation. rs12329760 (c.478G>A, p. V160M) was associated with a reduced risk of moderate symptoms. East Asian-specific genetic variation in TMPRSS2 is one of the molecular determinants of COVID-19 susceptibility and severity.
2023 | Year | 04 | Month | 11 | Day |
Persons infected with novel coronavirus and non-infected close contacts
Medical interview, stress survey, clinical examination, specimen collection for genetic testing
None
Primary endpoint IFNlamda4 gene polymorphism
Secondary endpoints
MxA gene polymorphism
Percentage of anti-COVID-19 antibody titer positive
T-Spot positivity rate
Laboratory findings, serum cytokine levels, etc.
Evaluation of stress status and stress tolerance
Completed
2020 | Year | 09 | Month | 25 | Day |
2020 | Year | 09 | Month | 25 | Day |
2020 | Year | 09 | Month | 25 | Day |
2021 | Year | 02 | Month | 28 | Day |
(Primary endpoint) IFN-lamda4 gene polymorphism
(Secondary evaluation item)
(1) MxA gene polymorphism
(2) Anti-COVID-19 antibody titer positive rate
(3) T-Spot positive rate
(4) Values of each clinical laboratory finding, serum cytokine, etc.
(5) Evaluation of stress status and stress tolerance
2020 | Year | 10 | Month | 09 | Day |
2023 | Year | 04 | Month | 11 | Day |
Value
https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000047878
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