Unique ID issued by UMIN | UMIN000039528 |
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Receipt number | R000045051 |
Scientific Title | An epigenetic analysis and gene expression profiling on autoimmune gastritis; a multicenter cross-sectional and prospective study |
Date of disclosure of the study information | 2020/03/01 |
Last modified on | 2022/03/17 13:23:16 |
An epigenetic analysis and gene expression profiling on autoimmune gastritis; a multicenter cross-sectional and prospective study
An epigenetic analysis and gene expression profiling on autoimmune gastritis
An epigenetic analysis and gene expression profiling on autoimmune gastritis; a multicenter cross-sectional and prospective study
An epigenetic analysis and gene expression profiling on autoimmune gastritis
Japan |
autoimmune gastritis
Gastroenterology |
Others
YES
1) To clarify differences in molecular morphology between AIG and HP gastritis and to clarify the mechanism through which malignant tumors develop from chronic inflammation in AIG
Others
2) To contribute to worldwide research on AIG by registering our genome-wide methylation and comprehensive gene expression information on a public database
Exploratory
Gene expression profiling and epigenetic analysis
Statistical analysis associated with the risk of neoplasm emergence
Observational
20 | years-old | <= |
Not applicable |
Male and Female
1) Case with confirmed diagnosis of AIG
2) Case with confirmed diagnosis of active HP infection
3) Case without chronic gastritis by endoscopy and inapplicable to 1),2)
-Cases with medical history of H. pylori eradication treatment
-Cases with regular use of proton pomp inhibitor (PPI) / potassium-competitive acid blocker (P- CAB)
-Cases with medical history of surgical operation of the upper digestive tract
-Cases with medical history of malignant disease (last 5 years, with the exception of intramucosal cancer cured by local treatment)
-Patients with hereditary gastrointestinal tumor diseases (familial adenomatous polyposis, Lynch syndrome, hereditary nonpolyposis colorectal cancer, Peutz-Jeghers syndrome, Cowden syndrome, hereditary diffuse gastric cancer etc.)
-Cases with use of 2 or more antiplatelet drugs or anticoagulants, or with coagulation abnormalities
-Cases with regular use of steroids
-Minor/elderly person/handicapped person who require special consideration
50
1st name | Nobutake |
Middle name | |
Last name | Yamamichi |
Graduate School of Medicine, The University of Tokyo
Center for Epidemiology and Preventive Medicine
113-8655
7-3-1, Hongo, Bunkyo-ku, Tokyo, Japan
03-3815-5411
nyamamic-tky@umin.ac.jp
1st name | Keiko |
Middle name | |
Last name | Niimi |
Graduate School of Medicine, The University of Tokyo
Center for Epidemiology and Preventive Medicine
113-8655
7-3-1, Hongo, Bunkyo-ku, Tokyo, Japan
03-3815-5411
k-niimi@umin.ac.jp
Graduate School of Medicine, The University of Tokyo, Center for Epidemiology and Preventive Medicine
Graduate School of Medicine, The University of Tokyo, Center for Epidemiology and Preventive Medicine
Self funding
Graduate School of Medicine, The University of Tokyo
7-3-1, Hongo, Bunkyo-ku, Tokyo, Japan
03-3815-5411
nyamamic-tky@umin.ac.jp
NO
国立がん研究センター研究所・エピゲノム解析分野(東京都) National Cancer Center Research Institute, Division of Epigenomics
岡山大学バイオバンク(岡山県) Okayama University Hospital, Biobank
JCHO滋賀病院・総合診療科(滋賀県) JCHO Shiga Hospital, General medical department
奈良県立医科大学・消化器/内分泌代謝内科(奈良県) Nara Medical University Hospital, Gastroenterology / Metabolism and endocrinology
浜松医科大学・臨床研究管理センター(静岡県) Hamamatsu University Hospital, Center for Clinical research
徳島県総合健診センター(徳島県) Tokushima health examination center
四谷メディカルキューブ・消化器内科(東京都) Yotsuya Medical Cube, Gastroenterology
湘南鎌倉総合病院(神奈川県) Shonan Kamakura General Hospital
2020 | Year | 03 | Month | 01 | Day |
Unpublished
Enrolling by invitation
2019 | Year | 12 | Month | 06 | Day |
2019 | Year | 12 | Month | 16 | Day |
2020 | Year | 03 | Month | 01 | Day |
2030 | Year | 03 | Month | 31 | Day |
Gene expression profiling and epigenetic analysis
2020 | Year | 02 | Month | 18 | Day |
2022 | Year | 03 | Month | 17 | Day |
Value
https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000045051
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