Unique ID issued by UMIN | UMIN000039424 |
---|---|
Receipt number | R000044803 |
Scientific Title | The effectiveness of ACE-Inhibitor for preventing pneumonia; Systematic review and meta-analysis |
Date of disclosure of the study information | 2020/02/07 |
Last modified on | 2020/02/07 11:33:28 |
The effectiveness of ACE-Inhibitor for preventing pneumonia; Systematic review and meta-analysis
The effectiveness of ACE-Inhibitor for preventing pneumonia; Systematic review and meta-analysis
The effectiveness of ACE-Inhibitor for preventing pneumonia; Systematic review and meta-analysis
The effectiveness of ACE-Inhibitor for preventing pneumonia; Systematic review and meta-analysis
Japan |
Pneumonia
Medicine in general | Pneumology | Neurology |
Geriatrics |
Others
NO
To assess the effectiveness of ACE inhibitors for prevention of pneumonia.
Efficacy
Incidence of pneumonia(Duration: the longest follow-up of each primary study), Definition: the presence of new pneumonic changes in the chest x-ray and clinical signs of pneumonia; cough, fever, sputum production and pleuritic chest pain. we will also accept pneumonia as the original authors defined)
Mortality(Duration: the longest follow-up of each primary study)
Withdrawal due to adverse effects(Duration: the longest follow-up of each primary study)
Swallowing function(Duration: the longest follow-up of each primary study, Definition:Assessed by the Royal Brisbane Hospital Outcome Measure for Swallowing(RBHOMS) score, the dysphagia severity rating scale (DSRS), the functional oral intake scale (FOIS), the dysphagia outcome and severity scale (DOSS), or water swallowing tests)
Others,meta-analysis etc
18 | years-old | <= |
Not applicable |
Male and Female
Nothing
Nothing
0
1st name | Hideki |
Middle name | |
Last name | Tsunoda |
Shiga University of Medical Science Hospital
Department of family medicine
520-2192
Seta Tsukinowa-cho, Otsu, Shiga, Japan
077-548-2929
hidekit0731@gmail.com
1st name | Hideki |
Middle name | |
Last name | Tsunoda |
Shiga University of Medical Science Hospital
Department of family medicine
520-2192
Seta Tsukinowa-cho, Otsu, Shiga, Japan
077-548-2929
hidekit0731@gmail.com
Shiga University of Medical Science Hospital, Department of family medicine
Shiga University of Medical Science Hospital, Department of family medicine
Other
Shiga University of Medical Science Hospital
Seta Tsukinowa-cho, Otsu, Shiga, Japan
077-548-2929
hidekit0731@gmail.com
NO
2020 | Year | 02 | Month | 07 | Day |
Unpublished
Preinitiation
2020 | Year | 02 | Month | 07 | Day |
2020 | Year | 02 | Month | 07 | Day |
2022 | Year | 02 | Month | 07 | Day |
<Types of studies>
We will include all randomized controlled trials(RCTs), quasi-RCTs and observational studies.
<Search Methods for identification of studies>
We will search the following databases for the relevant studies.
the Cochrane Central Register of Controlled Trials(CENTRAL);
MEDLINE via Ovid;
EMBASE;
We will also use the resources below.
the World Health Organization International Clinical Trials Platform Search Portal(ICTRP)
ClinicalTrials.gov
We will also search reference lists of included studies and clinical practice guidelines(ACC/ AHA/ ESC/ ESH).
<Assessment of risk of bias in included studies>
RCTs will be assessed by two authors independently using Risk of Bias 2 tool.
Quasi-RCT/ non-RCT/ Observational studies will be assessed using Newcasstle-Ottawa scale
<Subgroup analysis and investigation of heterogeneity>
We will perform subgroup analysis for the primary outcome (incidence of pneumonia) as follows.
1. Race: Asian or not
2. Patients with or without a history of stroke.
3. Patients with or without neurodegenerative diseases.
4. Age: Elderly patients(Studies that included a minority(<20%) of patients under 65 years old will be included.) or not.
5. Study follow-up: short (<= 3 months), intermediate (3 months to 24 months), or long term (> 24 months)
<Sensitivity analysis>
We will perform sensitivity analysis for the primary outcome as follows.
1. Exclusion of studies using imputed statistics.
2. Exclusion of studies using the diagnostic criteria of pneumonia other than the presence of new pneumonic changes in the chest x-ray and clinical signs of pneumonia; cough, fever, sputum production and pleuritic chest pain.
3. Using the effect estimates from univariable analyses instead of those from multivariable analyses
<"Summary of findings" tables>
We will present following results of the review in "Summary of findings" tables.
1. The incidence rate of pneumonia
2. Mortality
3. Withdrawal due to adverse effects
4. Swallowing function
2020 | Year | 02 | Month | 07 | Day |
2020 | Year | 02 | Month | 07 | Day |
Value
https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000044803