Unique ID issued by UMIN | UMIN000038573 |
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Receipt number | R000043959 |
Scientific Title | A comprehensive research on identifying factors to predict transition to psychosis in participants at At-Risk Mental State by using Rorschach profiles and stress-related biomarkers in saliva. |
Date of disclosure of the study information | 2019/11/15 |
Last modified on | 2019/11/13 21:35:10 |
A comprehensive research on identifying factors to predict transition to psychosis in participants at At-Risk Mental State by using Rorschach profiles and stress-related biomarkers in saliva.
Predictive factors for transition to psychosis in ARMS subjects
A comprehensive research on identifying factors to predict transition to psychosis in participants at At-Risk Mental State by using Rorschach profiles and stress-related biomarkers in saliva.
Predictive factors for transition to psychosis in ARMS subjects
Japan |
schizophrenia, At-Risk Mental State
Psychiatry |
Others
NO
The objective is to explore predictive biomarkers in At Risk Mental State (ARMS) subjects during transition to psychosis, focusing on changes in psychological characteristics and changes in stress-related biomarkers in saliva.
Others
Comparison of Rorschach profiles and biomarkers between ARMS subjects, schizophrenia subjects and healthy controls.
Exploratory
Others
Not applicable
(a)Rorschach test
(b)Structured Interview for Prodromal Syndromes: SIPS
(c)The Scale of Prodromal Symptoms: SOPS
(d)Cortisol in saliva 2ml: alpha-Amylase, CRP (C-Reactive Protein), IL-6, IL-1-beta, in saliva.
(a)the Scale to Assess Unawareness of Mental Disorder Japanese Version: SUMD-J
(b)Subjective Well-being under Neuroleptic drug treatment Short form, Japanese version: SWNS-J
(c)Positive and Negative Syndrome Scale: PANSS
(d)The Brief Assessment of Cognition in Schizophrenia: BACS
(e)Beck Depression Inventory-2: BDI-2
(f)Height, weight, smoking status
Observational
15 | years-old | <= |
40 | years-old | >= |
Male and Female
Basic standards
1)Provide consent to sample bioinformation, capable and willing to follow the research process.
2)Age between 15 to 40
3)Total IQ higher than or equal to 70
UHR group
1)Meet at least one out of the three types of symptomatology as below (You should be aware that the three types of prodromal symptoms are not mutually exclusive. A patient may fulfill more than one type of symptomatology).
The Criteria of Prodromal Syndromes: COPS
A)Brief Intermittent Psychotic Syndromes: BIPS
B)Attenuated Positive Symptom Syndrome: APSS
C)Genetic Risk and Deterioration Syndrome: GRDS
Health Controls
1)Healthy controls, who were age and sex matched with UHR group.
1)Those who have neurologic or medical neurologic or medical conditions as below: history of head trauma with loss of consciousness, chronic pulmonary disease, kidney disease, chronic liver disease, thyroid disease, active cancer, cerebrovascular disease, epilepsy, neurological disorder, substance related disorder, or mental retardation(IQ<70), obvious history of psychosis.
2)Those who are not seeking for help.
3)Those who suffer from autoimmune disease (SLE, hyperthyroidism: Graves' disease, ulcerative colitis, Crohn's disease).
4)Regular use of steroid or NSAID.
5)The attending physician decided that the patient was inappropriate to participate in the study.
168
1st name | Tsubasa |
Middle name | |
Last name | Morimoto |
Nara Medical University
Department of Psychiatry Psychiatric Institute
6348522
840 Shijocho Kashihara Nara
+81-744-22-3051
tsubasa@naramed-u.ac.jp
1st name | Naoko |
Middle name | |
Last name | Kishimoto |
Nara Medical University
Department of Psychiatry Psychiatric Institute
6348522
840 Shijocho Kashihara Nara
+81-744-22-3051
naoko@naramed-u.ac.jp
Nara Medical University
Japan Science and Technology Agency
Japanese Governmental office
Nara Medical University
840 Shijocho Kashihara Nara
+81-744-22-3051
naoko@naramed-u.ac.jp
NO
2019 | Year | 11 | Month | 15 | Day |
Unpublished
Open public recruiting
2019 | Year | 04 | Month | 24 | Day |
2019 | Year | 08 | Month | 21 | Day |
2019 | Year | 08 | Month | 21 | Day |
2025 | Year | 03 | Month | 31 | Day |
nothing special
2019 | Year | 11 | Month | 13 | Day |
2019 | Year | 11 | Month | 13 | Day |
Value
https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000043959
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