Unique ID issued by UMIN | UMIN000038487 |
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Receipt number | R000043845 |
Scientific Title | USE OF RIFAXIMIN THERAPY IN PRIMARY PREVENTION OF HEPATORENAL SYNDROME IN CIRRHOTIC PATIENTS WITH ASCITES |
Date of disclosure of the study information | 2019/11/03 |
Last modified on | 2019/11/03 21:35:36 |
USE OF RIFAXIMIN THERAPY IN PRIMARY PREVENTION OF HEPATORENAL SYNDROME IN CIRRHOTIC PATIENTS WITH ASCITES
USE OF RIFAXIMIN THERAPY IN PRIMARY PREVENTION OF HEPATORENAL SYNDROME IN CIRRHOTIC PATIENTS WITH ASCITES
USE OF RIFAXIMIN THERAPY IN PRIMARY PREVENTION OF HEPATORENAL SYNDROME IN CIRRHOTIC PATIENTS WITH ASCITES
USE OF RIFAXIMIN THERAPY IN PRIMARY PREVENTION OF HEPATORENAL SYNDROME IN CIRRHOTIC PATIENTS WITH ASCITES
Asia(except Japan) |
Liver Cirrhosis with ascites
Medicine in general | Gastroenterology | Hepato-biliary-pancreatic medicine |
Nephrology | Adult |
Others
NO
To see incidence of Hepatorenal syndrome in rifaximin group vs control group.
Others
To see renal function test (i.e. urea and creatinine ) in rifaxamin group and control group
at baseline , 4 week, 8 week & 12 week.
Occurrence of hepatorenal syndrome within 12 weeks.
Change in urea and creatinine level at 4 week,8week and 12 week.
Interventional
Parallel
Randomized
Individual
Open -no one is blinded
Placebo
YES
Institution is not considered as adjustment factor.
Numbered container method
2
Prevention
Medicine |
Rifaximin group ,Tab rifaximin at a dose of 550mg BD for 12 weeks and other
standard treatment.
Non Rifaximin group,Only standar Rx.
18 | years-old | <= |
80 | years-old | > |
Male and Female
1.Age of the patients to be above 18 yrs .
2.Diagnosis of liver cirrhosis and documented ascites.
3.Child-Pugh score of 7 or more
1. Patients with renal impairment (serum creatinine>1.5mg/dl)
2. History of HRS, nephropathy and obstructive Uropathy
3. Recent exposure to radioactive materials and Nephrotoxic drugs
4. Sepsis
5. Hepatocellular carcinoma
6. History of allergic reaction with rifaxmin.
94
1st name | Sanjit |
Middle name | |
Last name | Karki |
Patan Academy of health sciences,Patan Hospital.
Medicine,Gastroenterology
44600
.Lagankhel,lalitpur,Nepal
9841277196
sanjitkarki@pahs.edu.np
1st name | Sanjit |
Middle name | |
Last name | Karki |
Patan Academy of Health sciences
Medicine,Gastrenterology
44600
Lagankhel,lalitpur,Nepal
9841277196
sanjitkarki@pahs.edu.np
NationalAcademy of health Sciences,Bir Hospital
Department Of Medicine
Gastroenterology Unit
NationalAcademy of health Sciences,Bir Hospital
Department Of Medicine
Gastroenterology Unit
Other
National Academy of medical sciences
Mahaboudha,Kathmandu,Nepal
+977-1-4230710
admin@nams.org.np
NO
2019 | Year | 11 | Month | 03 | Day |
Unpublished
Open public recruiting
2019 | Year | 01 | Month | 02 | Day |
2019 | Year | 03 | Month | 12 | Day |
2019 | Year | 04 | Month | 01 | Day |
2020 | Year | 03 | Month | 30 | Day |
2020 | Year | 03 | Month | 30 | Day |
2020 | Year | 06 | Month | 15 | Day |
2019 | Year | 11 | Month | 03 | Day |
2019 | Year | 11 | Month | 03 | Day |
Value
https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000043845
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