Unique ID issued by UMIN | UMIN000038321 |
---|---|
Receipt number | R000043672 |
Scientific Title | Search for new markers in acute stroke using microRNA in blood |
Date of disclosure of the study information | 2019/11/01 |
Last modified on | 2020/05/12 12:21:43 |
Search for new markers in acute stroke using microRNA in blood
Search for new markers in acute stroke using microRNA in blood
Search for new markers in acute stroke using microRNA in blood
Search for new markers in acute stroke using microRNA in blood
Japan |
Stroke
Medicine in general | Neurology |
Others
YES
Measure blood microRNA and blood clot microRNA obtained by collecting blood clots as biomarkers for stroke patients, and examine the role of microRNAs and their usefulness as biomarkers.Blood microRNA is also measured from controls who have not developed a stroke.Using the neutrophil activity evaluation system, the activity state of neutrophils is also measured at the same time.
Others
none
Establish a simple marker such as troponin T in myocardial infarction in cerebral infarction and cerebral hemorrhage
Establish severity markers from quantitative results
Consider what changes occur in the body from miRNA profiles
Collect thrombus clogged in the brain due to cardiogenic cerebral embolism and examine miRNA in the thrombus
Is neutrophil activity different depending on the type and timing of stroke?
Is miRNA related to neutrophil activity?
Observational
20 | years-old | <= |
85 | years-old | >= |
Male and Female
Stroke group (onset within 1 week): 250 cases
Control group (no history of stroke): 250 cases
Patients who cannot obtain the consent of the person and the blood relative (within first degree)
Other patients judged by researchers as inappropriate
500
1st name | ARATA |
Middle name | |
Last name | ABE |
Tokyo Metropolitan Tama Medical Center
Department of Neurology and Stroke Medicine
183-8524
2-8-29 Musashidai, Fuchu City, Tokyo, Japan
+81-42-323-5111
abe@nms.ac.jp
1st name | Emiko |
Middle name | |
Last name | Koba |
Tokyo Metropolitan Tama Medical Center
Clinical Research Department
183-8524
2-8-29 Musashidai, Fuchu City, Tokyo, Japan
+81-42-323-5111
tamarinshou@tmhp.jp
Tokyo Metropolitan Tama Medical Center
Tokyo Metropolitan Tama Medical Center
Local Government
Tokyo Metropolitan Tama Medical Center
2-8-29 Musashidai, Fuchu City, Tokyo, Japan
+81-42-323-5111
Yuuko_Hachisu@member.metro.tokyo.jp
YES
30-40
Tokyo Metropolitan Tama Medical Center
2019 | Year | 11 | Month | 01 | Day |
Unpublished
280
Terminated
2018 | Year | 06 | Month | 11 | Day |
2018 | Year | 06 | Month | 11 | Day |
2018 | Year | 06 | Month | 12 | Day |
2019 | Year | 05 | Month | 31 | Day |
2019 | Year | 05 | Month | 31 | Day |
Registered patients listen to medical history at the first visit and hospitalization, and perform general blood tests, ultrasonography, and head MRI. In this study, extra blood is used for blood tests for medical purposes (performed in the blood collection room) at regular or irregular intervals.
Procedure
1 Obtain patient explanation and consent
2 After taking a blood test, go to the laboratory to take a blood sample
3 Treat whole blood (1-2 mL of residual blood) collected in EDTA-2K blood collection tube within 2 hours.
4 Put 1mL of whole blood into a tube containing 1mL of RNase-free water and 6mL of TRIzol LS Reagent.
5 Stir vigorously and store frozen at -80 degrees.
6 When the number of specimens has increased to some extent, contact the analysis organization to have the specimens picked up and handed over. A very small amount of blood is collected from the fingertip of a registered patient who has obtained consent using a needle for blood glucose measurement. In this study, although it is invasive, blood is collected according to the conventional procedure for blood glucose measurement, so there is no excessive invasion.
2019 | Year | 10 | Month | 17 | Day |
2020 | Year | 05 | Month | 12 | Day |
Value
https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000043672
Research Plan | |
---|---|
Registered date | File name |
Research case data specifications | |
---|---|
Registered date | File name |
Research case data | |
---|---|
Registered date | File name |