Unique ID issued by UMIN | UMIN000037462 |
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Receipt number | R000042709 |
Scientific Title | Study on influence on intraoral sense (taste and the sense of touch) of nitrous oxide for healthy adults |
Date of disclosure of the study information | 2019/08/01 |
Last modified on | 2021/01/26 18:24:57 |
Study on influence on intraoral sense (taste and the sense of touch) of the laughing gas for healthy adults
Influence on intraoral sense of the laughing gas
Study on influence on intraoral sense (taste and the sense of touch) of nitrous oxide for healthy adults
Influence on intraoral sense of nitrous oxide
Japan |
Dental phobia
Dental medicine | Adult |
Others
NO
Nitrous oxide is discovered and is going to greet 250 years. Nitrous oxide was effective in the "painkilling" "sedation" "poor memory" and has been used for initial first aid at the time of delivery in dental treatment all over the world. By the dental treatment, many patients who came held uneasiness, strain, fear, the unpleasant feelings such as the pain, and such feelings have been used expecting an effect of the "sedation" "poor memory" among other things to enlarge the risk such as the aggravation of complications much less the resistance to the dental treatment of the patient. Nitrous oxide is shown to act on hearing and the sense of touch, optic restraint in a past study, but the influence on taste is not apparent. I have a sense of fear for the intraoral sense (taste and the sense of touch) except the sense of pain to feel during dental treatment in the dental phobia patient and may lead to a refusal action. It is intended that I clarify it about usefulness of the nitrous oxide use to a dental treatment patient by inspecting the effect to an intraoral sense of the nitrous oxide in this study.
Efficacy
I obtain its consent with predetermined written consent at the time of a study cooperation request. I let a target person obtained its consent reply a young man, an adult sense profile and a questionnaire.
Under 0% of laughing gas (nitrous oxide), 20%, 30%, 50%, 70%, I carry out following experiments.
1.Blood pressure, the pulse, temperature, ventilatory frequency, the measurement of the percutaneous arterial blood oxygen saturation
2.Judgment (Ramsay score) of the sedation degree by the sedation score
3.The measurement (a mental stress activates excitement of the sympathetic system, and amylase activity increases as an internal self-defense reaction.) of saliva amylase
4.Examination of electric pulpal stimulation (A-delta fiber of four or five maxillary pulps, the threshold measurement by the C fiber stimulation)
5.The measurement of the surface of a body ache by the perception meter (10-20 g) and the oral pain
6.Examination of taste with the electric taste meter
7.Examination of taste with the reagent for examinations for taste qualitative fixed-quantity of the filter paper disk (sweetness, saltiness, acidity, bitterness)
8.Examination for R-R distance (examination of heart rate change)
Observational
20 | years-old | <= |
40 | years-old | >= |
Male and Female
The person that I performed written informed consent by the adult volunteer including the student of Kyushu Dental College, and consent was provided.
The person who corresponds to a taboo of the laughing gas. Or the person that a case and the agreement that had difficulty in understanding of study contents were not provided.
100
1st name | NOZOMU |
Middle name | |
Last name | HARANO |
Kyushu Dental University
Dental Anesthesiology
803-8580
2-6-1, manaduru, kokurakitaku, kitakyushu city, Fukuoka, Japan
093-581-1131
harano@kyu-dent.ac.jp
1st name | Nozomu |
Middle name | |
Last name | Harano |
Kyushu Dental University
Dental Anesthesiology
803-8580
2-6-1, manaduru, kokurakitaku, kitakyushu city, Fukuoka, Japan
093-581-1131
harano@kyu-dent.ac.jp
Kyushu Dental University
Japan Science and Technology Agency
Japanese Governmental office
Kyushu Dental University
2-6-1, manaduru, kokurakitaku, kitakyushu city, Fukuoka, Japan
093-701-9551
harano@kyu-dent.ac.jp
NO
2019 | Year | 08 | Month | 01 | Day |
Unpublished
Completed
2019 | Year | 04 | Month | 09 | Day |
2019 | Year | 06 | Month | 03 | Day |
2019 | Year | 07 | Month | 01 | Day |
2019 | Year | 12 | Month | 01 | Day |
There is no Important Notice.
2019 | Year | 07 | Month | 24 | Day |
2021 | Year | 01 | Month | 26 | Day |
Value
https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000042709
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