Unique ID issued by UMIN | UMIN000037410 |
---|---|
Receipt number | R000042587 |
Scientific Title | Synaptic density and tau deposition in dementia |
Date of disclosure of the study information | 2019/07/18 |
Last modified on | 2022/01/18 09:21:31 |
Pathophysiology of dementia on synaptic density and tau deposition in the brain
Pathophysiology of dementia on synaptic density and tau deposition in the brain
Synaptic density and tau deposition in dementia
Synaptic density and tau deposition in dementia
Japan |
The purpose of this study is to evaluate levels of different tau proteins using [18F]PM-PBB3 and [11C]PBB3 along with changes in synaptic density in patients with dementia and healthy subjects.
Neurology | Psychiatry | Adult |
Others
NO
The purpose of this study is to evaluate levels of different tau proteins using [18F]PM-PBB3 and [11C]PBB3 along with changes in synaptic density in patients with dementia and healthy subjects.
Bio-availability
Exploratory
Explanatory
Not applicable
Difference in [18F]PM-PBB3 binding, and [11C]PBB3 binding. Changes in [11C]UCB-J
Correlations between [11C]UCB-J and tau deposition
Interventional
Single arm
Non-randomized
Open -no one is blinded
Self control
1
Diagnosis
Other |
Intravenous injection of PET tracers
20 | years-old | <= |
85 | years-old | > |
Male and Female
Healthy participants aged 20 to 85 years or below
1.Individuals who have no history of psychiatric disease
2.Individuals who are consent to participate in this study
Patients
Met with criteria for AD, DLB and FTLD
1.Individuals who are nursing, pregnant and have a chance of pregnancy.
2.Individuals who have claustrophobia.
3.Individuals with illness that affects the study
4.Individuals who are assessed unsuitable for participants by doctors in charge.
60
1st name | Yasuomi |
Middle name | |
Last name | Ouchi |
Hamamatsu University School of Medicine
Department of Biofunctional Imaging
431-3192
1-20-1 Handayama, Higashi-ku, Hamamatsu city, Shizuoka, Japan
053-435-2466
ouchi@hama-med.ac.jp
1st name | Yasuomi |
Middle name | |
Last name | Ouchi |
Hamamatsu University School of Medicine
Department of Biofunctional Imaging
431-3192
1-20-1 Handayama, Higashi-ku, Hamamatsu city, Shizuoka, Japan
053-435-2466
ouchi@hama-med.ac.jp
Department of Biofunctional Imaging, Hamamatsu University School of Medicine
Ministry of Education, Culture, Sports, Science and Technology
Japanese Governmental office
Hamamatsu Medical Photonics Foundation
Hamamatsu Photonics KK
Hamamatsu University School of Medicine, Study Support Division
1-20-1 Handayama, Higashi-ku, Hamamatsu city, Shizuoka, Japan
053-435-2680
rinri@hama-med.ac.jp
NO
2019 | Year | 07 | Month | 18 | Day |
Unpublished
Open public recruiting
2019 | Year | 07 | Month | 18 | Day |
2018 | Year | 10 | Month | 05 | Day |
2019 | Year | 07 | Month | 19 | Day |
2023 | Year | 07 | Month | 18 | Day |
2019 | Year | 07 | Month | 18 | Day |
2022 | Year | 01 | Month | 18 | Day |
Value
https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000042587