Unique ID issued by UMIN | UMIN000035860 |
---|---|
Receipt number | R000040578 |
Scientific Title | Study on effect of obesity surgery by quantitative methylation assay of obesity-related gene |
Date of disclosure of the study information | 2019/02/14 |
Last modified on | 2019/02/12 21:40:02 |
Study on effect of obesity surgery by quantitative methylation assay of obesity-related gene
Study on effect of obesity surgery by quantitative methylation assay of obesity-related gene
Study on effect of obesity surgery by quantitative methylation assay of obesity-related gene
Study on effect of obesity surgery by quantitative methylation assay of obesity-related gene
Japan |
Obesity
Endocrinology and Metabolism | Gastrointestinal surgery |
Others
YES
In recent years, the effectiveness of obesity surgery on patients with high obesity has attracted worldwide attention not only as a weight loss surgery but also as a metabolic improvement surgery including diabetes.There are many unclear points in details of the weight loss effect of obesity surgery.In addition, there are individual differences in the intervention effect of surgery. The reason why weight reduction effect differs among individuals is unknown.Three factors are considered for the onset and progression of obesity: an obesity-related gene which is an inherent property of the individual itself, epigenetics which influences the expression pattern of the postnatal environmental factor later, and lifestyle such as momentum I will.It is considered that its role in actual obesity formation and therapeutic effect is not important to the obesity related gene itself.Rather, it is thought that epigenetics, ie, gene expression regulatory mechanism by DNA methylation, is greatly involved in actual obesity formation and therapeutic effects.In this research, we will examine the following discussion hypothesis.The effect of weight loss by obesity surgery in the treatment of obesity is due to the change in phenotype of obesity-related genes by epigenetics (DNA methylation).Specifically, we will examine the quantitative change of obesity-related gene methylation by obesity surgery for the outpatient with obesity as a primary endpoint.
Efficacy
Exploratory
Explanatory
Not applicable
Quantitative evaluation of obesity-related gene methylation before obesity surgery operation and 6 months after surgery in obese patients
Observational
20 | years-old | <= |
65 | years-old | > |
Male and Female
1)Patients whose age ranges from 20 years to under 65 when acquiring consent
2)Patients satisfying the adaptation condition of obesity surgery at the time of acquiring consent
3)After receiving sufficient explanation for participation in this study, patients who sufficiently understand and obtained document consent by their own voluntary intention
1)Patients complicated of serious heart failure / arrhythmia
2)Patients with severe and under-treated underlying diseases
3)patients with secondary obesity due to endocrinology, drugs, etc.
4)Patients who are inappropriate for obesity surgery due to underlying diseases
5)Those who have judged that the research director and the research assignee are inappropriate as the research subject
50
1st name | |
Middle name | |
Last name | Shiojima Ichiro |
Kansai Medical University
Department of medicine II
2-2-2 Shin-machi,Hirakata City,Osaka 573-1191 Japan
072-804-0101
kmuinfo@hirakata.kmu.ac.jp
1st name | |
Middle name | |
Last name | Kazuhisa Takahashi |
Kansai Medical University
Department of medicine II
2-2-2 Shin-machi, Hirakata City, Osaka 573-1191 Japan
072-804-0101
kazuhisa.takahahi.kmu@gmail.com
Kansai Medical University
none
Other
NO
関西医科大学付属病院
2019 | Year | 02 | Month | 14 | Day |
Unpublished
Preinitiation
2018 | Year | 12 | Month | 28 | Day |
2019 | Year | 02 | Month | 15 | Day |
Target
Kansai Medical University Attached Hospital Health Science Center During obesity outpatient visit, 50 patients undergoing obesity surgery at this hospital are included.
Method and duration of study
(1) Research Period: After approval of the Medical Ethics Committee - March 31, 2021 (Registration end date: September 31, 2020)
(2) Research type / design
Cohort study
2019 | Year | 02 | Month | 12 | Day |
2019 | Year | 02 | Month | 12 | Day |
Value
https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000040578