Unique ID issued by UMIN | UMIN000035603 |
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Receipt number | R000040570 |
Scientific Title | Analysis of the efficacy of oral immunotherapy combined with brown rice-specific gamma-oryzanol for children with food allergy |
Date of disclosure of the study information | 2019/01/21 |
Last modified on | 2023/01/24 15:50:57 |
Analysis of the efficacy of oral immunotherapy combined with brown rice-specific gamma-oryzanol for children with food allergy
Analysis of the efficacy of oral immunotherapy combined with brown rice-specific gamma-oryzanol
Analysis of the efficacy of oral immunotherapy combined with brown rice-specific gamma-oryzanol for children with food allergy
Analysis of the efficacy of oral immunotherapy combined with brown rice-specific gamma-oryzanol
Japan |
Food allergy
Pediatrics |
Others
NO
To investigate the efficacy of gamma-oryzanol for children with food allergy
Gamma-oryzanol is a brewed non-alcoholic beverage derived from brown rice
Safety,Efficacy
Sustained unresponsiveness to middle-dose after 12 months.
Middle dose was defined as "half of a whole egg, 25 ml of cow's milk, 25g of Udon, 3g of peanut or 3g of nut".
Intestinal microbiota
Short chain fatty acids (Acetic acid, butyric acid, propionic acid, valeric acid) in serum
Changes of specific IgE, IgG, IgG4
Frequency of adverse reactions
Interventional
Single arm
Non-randomized
Open -no one is blinded
Historical
1
Treatment
Food |
Patient ingests brown rice-specific gamma-oryzanol for 1 year
5 | years-old | <= |
18 | years-old | >= |
Male and Female
Patients who failed low-dose oral food challenge
Low-dose was defined as "one eight of whole egg, 3 ml of cow's milk, 2g of Udon (Japanese wheat noodles), 0.5g of whole peanut or 0.5g of nut".
Decision of ineligibility by a physician
15
1st name | Motohiro |
Middle name | |
Last name | Ebisawa |
National Hospital Organization Sagamihara National Hospital
Department of Allergy, Clinical Research Center for Allergy and Rheumatology
252-0392
18-1, Sakuradai, Minamiku, Sagamihara City, Kanagawa, Japan, 252-0392
042-742-8311
Ssakura8010@foodallergy.jp
1st name | Ken-ichi |
Middle name | |
Last name | Nagakura |
National Hospital Organization Sagamihara National Hospital
Department of pediatrics
252-0392
18-1, Sakuradai, Minamiku, Sagamihara City, Kanagawa, Japan, 252-0392
042-742-8311
k.nagakura@foodallergy.jp
National Hospital Organization Sagamihara National Hospital
Japan Agency for Medical Research and Development (AMED)
Japanese Governmental office
Japan
Second Department of Internal Medicine, Graduate School of Medicine, University of the Ryukyus
National Hospital Organization Sagamihara National Hospital
18-1, Sakuradai, Minamiku, Sagamihara City, Kanagawa, Japan, 252-0392
042-742-8311
222-rinri@mail.hosp.go.jp
NO
2019 | Year | 01 | Month | 21 | Day |
Unpublished
Completed
2019 | Year | 01 | Month | 01 | Day |
2018 | Year | 05 | Month | 15 | Day |
2019 | Year | 01 | Month | 21 | Day |
2021 | Year | 03 | Month | 31 | Day |
2019 | Year | 01 | Month | 21 | Day |
2023 | Year | 01 | Month | 24 | Day |
Value
https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000040570
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