Unique ID issued by UMIN | UMIN000035150 |
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Receipt number | R000040064 |
Scientific Title | Effect of exercise intervention on cognitive and physical function in pre-dialysis CKD patients: A randomized controlled trial |
Date of disclosure of the study information | 2018/12/05 |
Last modified on | 2020/12/07 17:13:21 |
Effect of exercise intervention on cognitive and physical function in pre-dialysis CKD patients: A randomized controlled trial
Effect of exercise intervention for health in pre-dialysis CKD patients
Effect of exercise intervention on cognitive and physical function in pre-dialysis CKD patients: A randomized controlled trial
Effect of exercise intervention for health in pre-dialysis CKD patients
Japan |
CKD stages G3-4 patients
Nephrology | Rehabilitation medicine |
Others
NO
We will investigate the effect of exercise intervention on cognitive and physical function in pre-dialysis CKD patients.
Efficacy
Confirmatory
Changes in cognitive (global cognition, several cognitive domains) evaluated after a 24-week intervention.
Physical (muscle strength, balance function, and gait speed) function, endothelial function, plasma brain-derived neurotrophic factor concentration, ADMA concentration, quality of life, depression status, and body composition evaluated after a 24-week intervention.
Interventional
Parallel
Randomized
Individual
Open -but assessor(s) are blinded
No treatment
2
Educational,Counseling,Training
Behavior,custom | Other |
Patients in the exercise group will undergo stretching, resistance, and aerobic training once a week at our rehabilitation center and more than twice a week at home for 24 weeks. The intensity will be prescribed at about 60% of one repetition maximum in the resistance training, and the rating of perceived exertion (Borg scale) is 11 to 13 in the aerobic training.
No specific intervention
65 | years-old | <= |
Not applicable |
Male and Female
Patients with CKD stages G3 and 4 (estimated glomerular filtration rate, 15-59 mL/min/1.73m2)
Gait assistance
Dementia
Receiving renal replacement therapy (RRT)
Planning to undergo RRT in 6 months
Arteriosclerosis obliterans with Fontaine classification stage 2 or higher
Exercise restriction by a medical doctor
Unstable angina pectoris
Poorly controlled diabetes mellitus
Inappropriate as participants judged by a medical doctor
60
1st name | |
Middle name | |
Last name | Naoto Tominaga |
Kawasaki Municipal Tama Hospital
Division of Nephrology and Hypertension, Department of Internal Medicine
1-30-37, Shukugawara, Tama-ku, Kawasaki, Kanagawa
+81-044-933-8111
tominaga@marianna-u.ac.jp
1st name | |
Middle name | |
Last name | Yuhei Otobe |
Kawasaki Municipal Tama Hospital
Department of Rehabilitation medicine
1-30-37, Shukugawara, Tama-ku, Kawasaki, Kanagawa
+81-044-933-8111
y-oto@marianna-u.ac.jp
Kawasaki Municipal Tama Hospital
Division of Nephrology and Hypertension, Department of Internal Medicine
Other
Other
NO
2018 | Year | 12 | Month | 05 | Day |
Unpublished
Completed
2018 | Year | 12 | Month | 01 | Day |
2019 | Year | 06 | Month | 05 | Day |
2019 | Year | 07 | Month | 01 | Day |
2020 | Year | 03 | Month | 31 | Day |
2020 | Year | 05 | Month | 08 | Day |
2020 | Year | 06 | Month | 22 | Day |
2020 | Year | 07 | Month | 10 | Day |
2018 | Year | 12 | Month | 05 | Day |
2020 | Year | 12 | Month | 07 | Day |
Value
https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000040064
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