Unique ID issued by UMIN | UMIN000035302 |
---|---|
Receipt number | R000039850 |
Scientific Title | Effect of oxytocin nasal spray on auditory automatic discrimination measured by mismatch negativity in schizophrenia |
Date of disclosure of the study information | 2018/12/19 |
Last modified on | 2019/06/24 15:18:59 |
Effect of oxytocin nasal spray on auditory automatic discrimination measured by mismatch negativity in schizophrenia
Effect of oxytocin nasal spray on auditory automatic discrimination measured by mismatch negativity
Effect of oxytocin nasal spray on auditory automatic discrimination measured by mismatch negativity in schizophrenia
Effect of oxytocin nasal spray on auditory automatic discrimination measured by mismatch negativity
Japan |
schizophrenia
Psychiatry | Adult |
Others
NO
For treating progressively cognitive dysfunction in schizophrenia, oxytocin nasal sprays are thought to improve social cognition, facial expression recognition, and smell identification ability. MMN is thought to acutely reflect cognitive dysfunction in schizophrenia. The purpose of this study is to clarify the effect on auditory cognitive function by oxytocin and to apply MMN to social function assessment of schizophrenia.
In this study, it is to clarify whether the effect of treatment of oxytocin nasal spray improve MMN and identify MMN paradigm that is sensitive to cognitive function assessment of schizophrenia.
Pharmacodynamics
Mismatch negativity(MMN)
Facial Emotion Selection Test(FEST)
Interventional
Parallel
Randomized
Individual
Double blind -all involved are blinded
Placebo
4
Treatment
Medicine |
Single administration of 24 IU of oxytocin nasal sprays to schizophrenia.
Single administration of 24 IU of placebo nasal sprays to schizophrenia.
Single administration of 24 IU of oxytocin nasal sprays to healthy subjects.
Single administration of 24 IU of placebo nasal sprays to healthy subjects.
20 | years-old | <= |
Not applicable |
Male and Female
Patients were diagnosed Schizophrenia in DSM-5 (Diagnostic and Statistical Manual of Mental Disorders), which was thought to be able to fully understand the contents of the experiment and its significance.
Exclusion criteria were epilepsy, mental retardation, a history of hypersensitivity to Oxytocin, drug abuse / dependence, continuous administration of Oxytocin, pregnancy, and a history of psychiatric or neurological disorders.
80
1st name | Ochiai |
Middle name | |
Last name | Haruka |
Fukushima Medical University
Department of Psychiatry
9601247
1, Hikarigaoka, Fukushima-shi, Fukushima
0245471331
haruka-o@fmu.ac.jp
1st name | Ochiai |
Middle name | |
Last name | Haruka |
Fukushima Medical University
Department of Psychiatry
9601247
1, Hikarigaoka, Fukushima-shi, Fukushima
0245471331
haruka-o@fmu.ac.jp
Fukushima Medical University
Ministry of Education, Culture, Sports, Science and Technology
Japanese Governmental office
Fukushima Medical University Medical Research Promotion Division Clinical Research Review Committee Secretariat
1, Hikarigaoka, Fukushima-shi, Fukushima
0245471825
rs@fmu.ac.jp
NO
2018 | Year | 12 | Month | 19 | Day |
Partially published
66
Completed
2016 | Year | 02 | Month | 01 | Day |
2016 | Year | 06 | Month | 08 | Day |
2016 | Year | 06 | Month | 08 | Day |
2019 | Year | 03 | Month | 31 | Day |
2018 | Year | 12 | Month | 18 | Day |
2019 | Year | 06 | Month | 24 | Day |
Value
https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000039850