Unique ID issued by UMIN | UMIN000034488 |
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Receipt number | R000039330 |
Scientific Title | Investigation on exhaled nitrogen chemicals in lung cancer patients undergoing lobectomy |
Date of disclosure of the study information | 2018/10/15 |
Last modified on | 2018/10/14 23:26:51 |
Investigation on exhaled nitrogen chemicals in lung cancer patients undergoing lobectomy
Investigation on exhaled nitrogen chemicals in lung cancer patients undergoing lobectomy
Investigation on exhaled nitrogen chemicals in lung cancer patients undergoing lobectomy
Investigation on exhaled nitrogen chemicals in lung cancer patients undergoing lobectomy
Japan |
lobectomy
Chest surgery | Anesthesiology | Intensive care medicine |
Adult |
Malignancy
NO
For patients with lung cancer who undergo lobectomy, to measure the concentration of exhaled nitrogen chemicals (NO, NO2, HONO) at the perioperative period and to evaluate the effect of surgery. Also, to evaluate not only the relevance between collapsed lung and non-collapsed lung but also the relevance to blood ROS, blood cytokines, and pulmonary function.
Others
epidemiology research
Exploratory
Pragmatic
Not applicable
change in exhaled NO, NO2, HONO concentration during perioperative period
1) relevance of exhaled NO, NO2, HONO and collapsed lung and non-collapsed lungs during perioperative period
2) relevance of exhaled NO, NO2, HONO and blood ROS during perioperative period
3) relevance of exhaled NO, NO2, HONO and blood cytokines during perioperative period
4) relevance of exhaled NO, NO2, HONO and pulmonary function during perioperative period
5) relevance of exhaled NO, NO2, HONO and duration of collapse pulmonary during perioperative period
Observational
20 | years-old | <= |
Not applicable |
Male and Female
1) patients over 20 years at the time of obtaining informed consent
2) patients with lung cancer up to stage II
3) patients scheduled for lobectomy
4) patients with ASA PS 1 to 2
1) patients undergoing surgery requiring general anesthesia within 3 months prior to obtaining informed consent
2) patients with heart disease
3) patients with arrhythmia
4) patients with poor control hypertenson
5) patients with respiratory dysfunction
6) patients with lung disease
7) patients with smoking history within 3 months before consent acquisition
8) patients with pulmonary hypertension
9) diabetic patients with poor control
10) patients with cerebrovascular disorders
11) patients with severe liver disease
12) patients with severe kidney disease
13) patients with declining blood clotting ability
14) patients with thrombocytopenia
15) patients who receive chemotherapy, radiation therapy, immunotherapy within 3 months prior to obtaining informed consent
16) patients with systemically or locally active infections
17) highly obese patients
18) women who may be pregnant or have a possibility of pregnancy
19) patients who received study drugs or investigational drugs within 3 months prior to obtaining informed consent
20) patinets whom research investigator has determined to be inappropriate
20
1st name | |
Middle name | |
Last name | Kazumi Funaki |
Tottori University
Division of Anesthesiology and Critical Care Medicine
36-1, Nishi-cho, Yonago, Tottori, Japan
0859-38-6657
funapon1116@gmail.com
1st name | |
Middle name | |
Last name | Kazumi Funaki |
Tottori University
Division of Anesthesiology and Critical Care Medicine
36-1, Nishi-cho, Yonago, Tottori, Japan
0859-38-6657
funapon1116@gmail.com
Division of Anesthesiology and Critical Care Medicin, Tottori University
Division of Anesthesiology and Critical Care Medicin, Tottori University
Self funding
NO
鳥取大学医学部附属病院(鳥取県)
2018 | Year | 10 | Month | 15 | Day |
Unpublished
Preinitiation
2018 | Year | 08 | Month | 06 | Day |
2018 | Year | 10 | Month | 15 | Day |
For patients with lung cancer who undergo lobectomy, to measure the concentration of exhaled nitrogen chemicals (NO, NO2, HONO) at the perioperative period and to evaluate the effect of surgery. Also, to evaluate not only the relevance between collapsed lung and non-collapsed lung but also the relevance to blood ROS, blood cytokines, and pulmonary function.
2018 | Year | 10 | Month | 14 | Day |
2018 | Year | 10 | Month | 14 | Day |
Value
https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000039330
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