Unique ID issued by UMIN | UMIN000034297 |
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Receipt number | R000039101 |
Scientific Title | Data analyses and biomarkers measurements of J-ADNI |
Date of disclosure of the study information | 2018/09/27 |
Last modified on | 2018/09/27 18:35:19 |
Data analyses and biomarkers measurements of J-ADNI
Data analyses and biomarkers measurements of J-ADNI
Data analyses and biomarkers measurements of J-ADNI
Data analyses and biomarkers measurements of J-ADNI
Japan |
Alzheimer's disease
Mild cognitive impairment
Neurology | Geriatrics | Psychiatry |
Radiology | Adult |
Others
NO
The purposes are pathophysiological investigation and early diagnosis of Alzheimer's disease using open data of J-ADNI ((Japanese Alzheimer's bDisease Neuroimaging Initiative), which were multi-center cohort study of Alzheimer's disease
Efficacy
Confirmatory
Pragmatic
Not applicable
To find and validate imaging and biomarker predictors for converting from MCI to AD dementia.
Others,meta-analysis etc
60 | years-old | <= |
84 | years-old | >= |
Male and Female
150 cases of normal aged individuals, 300 cases of MCI, 150 cases of early AD, whose language is Japanese.
Living at home, accompanied by a study partner.
The participants should sign agreement forms. In case the participant is not capable of agreeing, the study partner should sign in substitution.
Age: 60-84 years upon enrollment
Criteria for normal aged individuals
MMSE: 24-30
Scores of Wechsler memory Scale-R logical memory II (corrected for education), above the cut-off levels.
education 0-9 years: 3 or above
10-15 years: 5 or above
>16 years 9 or above
Criteria for amnestic MCI
Type 1: complaint of memory disturbance from the participant plus approval by the study partner
Type 2: memory disturbance approved by the study partner, without the subjective complaint of the participant
(excluded in case only with subjective memory complaint, without approval by the study partner)
MMSE: 24-30
Scores of Wechsler memory Scale-R logical memory II (corrected for education), below the cut-off levels.
education 0-9 years: 2 or lower
10-15 years: 4 or lower
>16 years 8 or lower
CDR 0.5 not depressed
Criteria for early AD
MMSE: 20-26
Scores of Wechsler memory Scale-R logical memory II (corrected for education), below the cut-off levels.
education 0-9 years: 2 or lower
10-15 years: 4 or lower
>16 years 8 or lower
CDR 0.5 or 1
Probable AD by the criteria of NINCDS-ADRDA
(Causes or diseases leading to dementia other than AD excluded)
1. Parkinson' disease, multiple cerebral infarction, Huntington's disease, normal pressure hydrocephalus, brain tumor, progressive supranuclear palsy, epilepsy, subdural hematoma, multiple sclerosis, head trauma with sequelae
2. Signs of brain infection, focal brain lesions (eg infarction) that may affect cognitive function.
3. Presence of pacemaker, arterial clip, artificial valves, artificial cochlea, and other magnetic/electroconductive metals in the body that may affect MRI
4. Major depression or bipolar disorder within past 1 year, addiction to alcohol or other drugs within past 2 years, presence of fatal or unstable diseases, vitamin B12 or folate deficiency, syphilis, thyroid function abnormality
5. administration of psychoactive drugs (defined in procedure manual)
6. administration of warfarin
0
1st name | |
Middle name | |
Last name | Takashi Kato |
National Center for Geriatrics and Gerontology
Department of Radiology
7-430, Morioka, Obu, Aichi, Japan
0562-46-2311
tkato@ncgg.go.jp
1st name | |
Middle name | |
Last name | Takashi Kato |
National Center for Geriatrics and Gerontology
Department of Radiology
7-430, Morioka, Obu, Aichi, Japan
0562-46-2311
https://humandbs.biosciencedbc.jp/hum0043-v1
tkato@ncgg.go.jp
National Center for Geriatrics and Gerontology
The Japan Agency for Medical Research and Development (AMED)
Other
NO
2018 | Year | 09 | Month | 27 | Day |
Unpublished
Terminated
2016 | Year | 08 | Month | 15 | Day |
2016 | Year | 08 | Month | 15 | Day |
Clinical/neuropsychological evaluation, neuroimaging work-ups and collection of biofluid samples are undertaken longitudinally at baseline, 6,12,24,36 M (normal individuals), baseline, 6,12,18,24,36M (MCI) and baseline, 6, 12, 24 M (early AD).
2018 | Year | 09 | Month | 27 | Day |
2018 | Year | 09 | Month | 27 | Day |
Value
https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000039101
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