Unique ID issued by UMIN | UMIN000032592 |
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Receipt number | R000037164 |
Scientific Title | Effects of polyphenol-enriched extracts from Wakame on muscle atrophy caused by cachexia |
Date of disclosure of the study information | 2018/07/01 |
Last modified on | 2018/05/14 20:50:51 |
Effects of polyphenol-enriched extracts from Wakame on muscle atrophy caused by cachexia
Effects of polyphenol-enriched Wakame diets on muscle atrophy
Effects of polyphenol-enriched extracts from Wakame on muscle atrophy caused by cachexia
Effects of polyphenol-enriched Wakame diets on muscle atrophy
Japan |
cachexia
Gastroenterology | Pneumology | Hematology and clinical oncology |
Malignancy
NO
Cachexia occasionally causes muscle atrophy. This atrophy is mediated by oxidative stress induced with proinflammatory cytokines. Recently polyphenols derived from plants have been reported to have several beneficial effects on cachexia. Wakame contains a lot of polyphenol, especially morin. In this study we will examined anti-muscle atrophy actions of polyphenol-enriched Wakame extracts on patients with cachexia.
Safety,Efficacy
Confirmatory
Pragmatic
Phase II
muscle volume
food intake, body weight, tumor size
Interventional
Parallel
Randomized
Individual
Open -but assessor(s) are blinded
Placebo
NO
NO
Institution is not considered as adjustment factor.
NO
Central registration
2
Treatment
Food |
Wakame Extracts with Chinese soup, 1.5 g/day, 28 days;
flour for control group, 1.5 g/day, 28 days
20 | years-old | <= |
Not applicable |
Male and Female
Pre-cachectic condition: In a state deviating from a normal state, weight loss is within 5%, a condition accompanied by anorexia and metabolic abnormality
Poor oral ingestion, accompanied by systemic inflammation, the condition of cachexia progressed (weight loss is 5% or more; or BMI 20% or less and weight loss 2% or more; or sarcopenia (muscle mass decreased, muscular strength and body function is decreased, BMI less than 18.5) and weight loss is 2% or more)
20
1st name | |
Middle name | |
Last name | Takeshi Nikawa |
Tokushima University Graduate School
Institute of Medical Biosciences, Department of Nutritional Physiology
3-18-15 Kuramoto-cho, Tokushima
088-633-9248
nikawa@tokushima-u.ac.jp
1st name | |
Middle name | |
Last name | Takeshi Nikawa |
Tokushima University Graduate School
Institute of Medical Biosciences, Department of Nutritional Physiology
3-18-15 Kuramoto-cho, Tokushima
088-633-9248
https://tokudai-seitaieiyo.jimdo.com/
nikawa@tokushima-u.ac.jp
Tokushima University
Cross-ministerial Strategic Innovation Promotion Program (SIP)
Japanese Governmental office
Japan
NO
徳島大学病院
2018 | Year | 07 | Month | 01 | Day |
Unpublished
Preinitiation
2018 | Year | 07 | Month | 01 | Day |
2018 | Year | 07 | Month | 01 | Day |
2018 | Year | 05 | Month | 14 | Day |
2018 | Year | 05 | Month | 14 | Day |
Value
https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000037164
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