Unique ID issued by UMIN | UMIN000030821 |
---|---|
Receipt number | R000034956 |
Scientific Title | Quantitative assessment of pulmonary blood flow in control subjects, subjects with chronic obstructive lung disease (COPD), or with pulmonary hypertension (PH) by 15O-H2O PET/CT |
Date of disclosure of the study information | 2018/01/19 |
Last modified on | 2019/07/25 12:12:43 |
Quantitative assessment of pulmonary blood flow in control subjects, subjects with chronic obstructive lung disease (COPD), or with pulmonary hypertension (PH) by 15O-H2O PET/CT
Quantitative assessment of pulmonary blood flow by 15O-H2O PET/CT
Quantitative assessment of pulmonary blood flow in control subjects, subjects with chronic obstructive lung disease (COPD), or with pulmonary hypertension (PH) by 15O-H2O PET/CT
Quantitative assessment of pulmonary blood flow by 15O-H2O PET/CT
Japan |
COPD, PH
Pneumology |
Others
NO
1.To assess and compare the pulmonary or myocardial blood flow and their heterogeneity of those flow in control subjects, patients with COPD, and in patients with PH.2.To compare the pulmonary blood flow assessed by 15O-H2O PET/CT and the diffusion capacity of carbon monoxide or transfer coefficient of the lung.in control subjects, patients with COPD, or with PH.Also in patient with PH, to compare the pulmonary blood flow assessed by 15O-H2O PET/CT and parameters of right heart catheterization, cardiac MRI,and Tc-MAA perfusion scintigraphy.3.To examine the pulmonary and myocardial flow reserve of blood flow in control subjects, patients with COPD, and patients with PH.4. To compare the pulmonary blood flow assessed by 15O-H2O PET/CT and the results of pulmonary function tests and scores of COPD activity test in patients with COPD. Particularly, to examine the relationships between quantity of the pulmonary blood flow assessed by 15O-H2O PET/CT and the severity of emphysema assessed by CT.
Others
Quantitative assessment of pulmonary blood flow by 15O-H2O PET/CT
Exploratory
Explanatory
Not applicable
Pulmonary blood flow corrected by lung volume
Heterogeniety of pulmonary blood flow Flow reserve of pulmonary blood flow Myocardial blood flow at rest and during exercise Lung attenuation volume pulmonary function test:FEV1,FEV1FVC,DLco,DLcoVA COPD assessment test scoreEchocardiography: LV/LA diameter/area/volume,EF,cardiac output, cardiac index,LV eccentricity index, tricuspid regurgitation velocity, tricuspid annulus movement distance, Tei index, IVC diameter cardio pulmonary exercise test peak VO2, AT, VE/VCO2, stress level at AT, HR, RER, VE, VD/VT cardiac MRI: LV/RV/LA/RA volume/index, cardiac output/index, stroke volume, ventricular wall thickness/volume/index, Pulmonary circulation time, existence and volume of late enhancementRight heart catheterization: pulmonary arterial pressure, pulmonary arterial wedge pressure, RV/RA pressure, CO,CI, PVR, venous oxygen saturation ,Qr/Qs Tc-MAA perfusion scintigraphy defect of perfusion in the lung, ventilation and perfusion mismatch, the ratio of the right lung perfusion to the left lung perfusion, shunt ratio
Interventional
Single arm
Non-randomized
Open -no one is blinded
Uncontrolled
1
Prevention
Other |
15O-H2O PET/CT
20 | years-old | <= |
Not applicable |
Male and Female
Control subjects:Subjects without any respiratory or cardiac or other disorders that might affect pulmonary blood volume COPD: Subjects with COPD who regularly visit Hokkaido university hospital.PH: Subjects who have the diagnosis of PH or are suspected of PH and regularly visit Hokkaido university hospital
1.Subjects who had participated in
other clinical trials within the past one month.
2.Subjects who will not follow the study protocol.
3.Subjects who are pregnant or who are during the lactating period and who are suspected of pregnancy.
4.Subjects who do not agree with contraception during the study.
5. Subjects who principal investigators or members of this research consider not to be suitable for this study.
20
1st name | |
Middle name | |
Last name | Kaoruko Shimizu |
Hokkaido University Hospital
First department of medicine
North 15 West 7, Kita-ku, Sapporo
011-706-5911
kaorukoshimizu@pop.med.hokudai.ac.jp
1st name | |
Middle name | |
Last name | Kaoruko Shimizu |
Hokkaido Univertisy Hospital
First department of medicine
North 15 West 7, Kita-ku, Sapporo
011-706-5911
kaorukoshimizu@pop.med.hokudai.ac.jp
Hokkaido University
Japan Science and Technology Agency
Japanese Governmental office
NO
北海道大学病院(北海道)
2018 | Year | 01 | Month | 19 | Day |
Unpublished
Completed
2017 | Year | 12 | Month | 28 | Day |
2018 | Year | 01 | Month | 22 | Day |
2018 | Year | 01 | Month | 24 | Day |
2019 | Year | 03 | Month | 31 | Day |
2018 | Year | 01 | Month | 15 | Day |
2019 | Year | 07 | Month | 25 | Day |
Value
https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000034956