UMIN-CTR Clinical Trial

Basic information
Official scientific title of the study	Japan Public Health Center-based prospective Study
Title of the study (Brief title)	JPHC Study
Region	Japan

Condition
Condition	Cancer, Cardiovascular disease, Diabetes Mellitus, lifestyle-related disease, mortality, etc.
Classification by specialty	Not applicable Adult
Classification by malignancy	Malignancy
Genomic information	YES

Objectives
Narrative objectives1	To elucidate the association between lyfestyle and health maintenance and improvement including cancer prevention based on cohort studies
Basic objectives2	Others
Basic objectives -Others	To establish evidence the association between lyfestyle and health maintenance and disease based on cohort studies
Trial characteristics_1
Trial characteristics_2
Developmental phase

Assessment
Primary outcomes	Cancer, Cardiovascular disease, Diabetes Mellitus, lifestyle-related disease, mortality
Key secondary outcomes

Base
Study type	Observational

Study design
Basic design
Randomization
Randomization unit
Blinding
Control
Stratification
Dynamic allocation
Institution consideration
Blocking
Concealment

Intervention
No. of arms
Purpose of intervention
Type of intervention
Interventions/Control_1
Interventions/Control_2
Interventions/Control_3
Interventions/Control_4
Interventions/Control_5
Interventions/Control_6
Interventions/Control_7
Interventions/Control_8
Interventions/Control_9
Interventions/Control_10

Eligibility
Age-lower limit	40 years-old <=
Age-upper limit	69 years-old >=
Gender	Male and Female
Key inclusion criteria	The JPHC Study conducted a baseline survey of 140420 registered residents aged 40-69 years within 11 public health center areas nationwide from 1990-94.
Key exclusion criteria	non-Japanese nationality, subjects who migrated before the start of the follow-up period.
Target sample size	140420

Research contact person
Name of lead principal investigator	Shoichiro Tsugane
Organization	National Cancer Center
Division name	Center for Public Health Sciences
Address	5-1-1 Tsukiji Chuo-ku Tokyo
TEL	03-3542-2511
Email	stsugane@ncc.go.jp

Public contact
Name of contact person	Norie Sawada
Organization	National Cancer Center
Division name	Center for Public Health Sciences
Address	5-1-1 Tsukiji Chuo-ku Tokyo
TEL	03-3542-2511
Homepage URL	http://epi.ncc.go.jp/jphc/index.html
Email	nsawada@ncc.go.jp

Sponsor
Institute	National Cancer Center
Institute
Department

Funding Source
Organization	National Cancer Center
Organization
Division
Category of Funding Organization	Japanese Governmental office
Nationality of Funding Organization

Other related organizations
Co-sponsor
Name of secondary funｄer(s)

Secondary IDs
Secondary IDs	NO
Study ID_1
Org. issuing International ID_1
Study ID_2
Org. issuing International ID_2
IND to MHLW

Institutions
Institutions

Other administrative information
Date of disclosure of the study information	2017 Year 08 Month 23 Day

Progress
Recruitment status	Main results already published
Date of protocol fixation	1989 Year 12 Month 31 Day
Anticipated trial start date	1990 Year 01 Month 01 Day
Last follow-up date
Date of closure to data entry
Date trial data considered complete
Date analysis concluded

Related information
URL releasing protocol
Publication of results	Partially published
URL releasing results
Results
Other related information	The JPHC Study is ongoing study. We will follw-up until Mar 31, 2024. The subjects have been followed for vital status and the occurrence of cancer and other diseases. As of December 2011, 24 000 deaths have been documented, as well as 17 000 cases of cancer, 6000 cases of stroke and 1100 cases of myocardial infarction. We have tested the association between potential causal factors and the incidence of or mortality from cancer and other diseases, and published >250 papers to date.

Management information
Registered date	2017 Year 08 Month 23 Day
Last modified on	2017 Year 08 Month 23 Day

Link to view the page
URL(English)	https://upload.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000032944